Institut de recherche biomédicale
     
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    Equipe : Gènes, nutriments et fer

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    Responsables :



    Our group is interested in the pathophysiological regulation of genes implicated in energy, oxygen and iron homeostasis and their possible implications in metabolic diseases and cancer. 

     

    Goal of the first team


    The goal of the first team is to precise the roles of hepcidin, the iron regulatory hormone, and HIF (Hypoxia Inducible factors) in iron homeostasis with respect to various aspects.

    Our objectives are divided into 4 main focuses:

    (1) to better characterize the pathophysiological roles of HIF and hepcidin in different key organs involved in maintaining body iron homeostasis

    (2) to identify hepcidin regulatory pathways

    (3) to develop new hepcidin-based diagnosis and therapeutic approaches and

    (4) to demonstrate that HIF and hepcidin are at the crossing points between infection and iron metabolism.

     

     sophie1

     

     Patents:
    - European patent application: (No. 10478987 filed on 05/24/2002): “Use of hepcidin as a regulator of iron homeostasis”. This patent has been granted in the US in January 2007.
    - European patent application (number EP 07 291 196.9, 02/10/2007): “Antigen-Binding proteins having specificity for human hepcidin”.

    Goal of the second team


    The goal of the second team (Marc Foretz and Benoit Viollet) is to decipher the physiological role of the energy sensor AMPK (AMP-activated protein kinase) in the regulation of cellular energy balance but also how AMPK integrates stress responses such as exercise as well as nutrient and hormonal signals to control energy expenditure and substrate utilization at the whole body level. Our studies will bring promise in the use of AMPK activators which represent a therapeutic opportunity to reverse the metabolic abnormalities associated with type 2 diabetes and obesity.

     

     Sophie2

     

     Methodology
    -Generation of transgenic mouse models
    -Cellular biology (primary culture of hepatocytes, macrophages, adipocytes and muscle cells and immortalized cell lines)
    -Molecular biology and physiology
    -Generation and in vivo injection of recombinant adenovirus
    -Models of infection and inflammation

    Key words
    Energy metabolism, metabolic disorders, AMPK, hepcidin, iron, HIF, infection, inflammation, metabolic syndromes