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    Tolerance induction and maintenance to islets transplants by CD3 antibody therapy

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    SÉMINAIRE DE L'INSTITUT COCHIN

    Sylvaine You 

    Sylvaine You

    INSERM U1151, INEM, Paris

     

    Jeudi 23 mars 2017 à 12h00

     

     invitée par Roberto Mallone

     

    Institut Cochin, 22 rue Méchain, 75014 Paris
    Salle de conférence Rosalind Franklin, 2e étage

     

    S. You obtained her PhD in Nantes, where she studied the mechanisms of immune tolerance towards porcine pancreatic islet xenografts in NOD mice. Her Postdoctoral Fellowship at the City of Hope Medical Center focused on the identification and characterization of autoantigen-specific CD4+ T cells in NOD mice using MHC II tetramers. S. You subsequently joined the team of L. Chatenoud to pursue her work on the pathophysiology of type 1 diabetes and on the regulatory mechanisms underlying the therapeutic effect of CD3 antibody immunotherapy  (Tregs, TGF-beta). She was recruited as an INSERM CR in 2007 and further concentrated her expertise on immune intervention strategies for islet autoimmunity and transplantation using different biological agents.
     
    Using an islet allograft model, her latest works provide evidence that tolerance induction and maintenance engage distinct mechanisms. More specifically, CD3 antibodies preferentially deplete alloreactive Th1 and cytotoxic CD8+ T cells, and Foxp3+ Tregs are critical to induce allograft tolerance. However, they are less important for maintaining this tolerant state, which predominantly relies on T-cell anergy through the use of TGF-beta and co-inhibitory signals. 

     

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