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    Cells sense of touch, how do they use it to perform directed migration?

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    SÉMINAIRE DE L'INSTITUT COCHIN

    Martial Balland 

    Martial Balland

    Laboratoire interdisciplinaire de Physique, LiPhy Grenoble

     

    Mercredi 22 mars 2017 à 12h00

     

     invité par Mireille Lambert

     

    Institut Cochin, 22 rue Méchain, 75014 Paris
    Salle de conférence Rosalind Franklin, 2e étage

    The most remarkable aspect of living tissue is their ability to maintain mechanical integrity as they are submitted to external forces such as those implicated in tissue remodelling (cell intercalation, cell migration, cell polarisation). The maintenance of such an integrity is a critical feature for tissue homeostasis and highly depends on the regulation of cell adhesion, shape and contractility.

    Conversely, several pathologies, such as metastasis dissemination, asthma, or sickle cell anemia, are systematically associated with the alteration of the mechanical properties of a given cell type.

    @ Lab, we are currently developing a combination of micropatterned substrates, optical technics and traction force microscopy in order to understand how mechanical forces are sensed and generated by eukaryotic cells.

     

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