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    HOMOLOGOUS RECOMBINATION AND CRYOPRESERVATION

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    Team Leader

    The Homologous Recombination and Cryopreservation facility provides expertise and assistance in the production of genetically modified mice that represent invaluable tools for the analysis of gene functions, creation of disease models or production of recombinant proteins. We are specialized in the generation of these models either by gene targeting in embryonic stem cells (constructs are prepared on demand and we provide advices to design the best gene targeting strategies) or by injection of the CRISPR/Cas9 systems in zygotes. The facility is committed to produce genetically modified animals for researchers at the Cochin Institute but is also open to external collaborations (academic research laboratories and pharmaceutical companies). In addition, our facility also offers embryo transfer rederivation and long-term preservation of the lineages (embryos or sperm cryopreservation)

     News

    • Chloé Got has joined the team in 2016
    • 2016: platform affilied to the network Celphedia
    • The platform received the label Iso9001 Version 2008 in 2012
    • Last publications

    Cécile Delettre, Laetitia Buret, Guy Rebillard, et al. Loss of function of Ywhah in mice induces deafness and cochlear outer hair cells de- generation. Cell Death Discovery 2016;2:16017.

    Patel K, Foretz M, Marion A, et al. The LKB1-salt-inducible kinase path- way functions as a key gluconeo- genic suppressor in the liver. Nat Commun. 2014;4;5:4535.

     

    Contact

    Plateforme PRHTEC

    Faculté de Médecine Cochin Port-Royal
    4th floor, rooms 4013-4014-4020 et 4021

    24, rue du Faubourg St Jacques
    75014 Paris.

    Marcio DO CRUZEIRO
    marcio.do-cruzeiro@inserm.fr
    +33 (0) 1 44 41 24 74
    Fax : +33 (0) 1 44 41 24 21