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    Pathogenesis of endometriosis

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    Endometriosis is a chronic hormone-dependent fibro-inflammatory gynecological disease. It affects nearly 10% of women of childbearing age and clinically results in intense pelvic pain and infertility. The disease is related to the presence of ectopic endometrium that forms cystic lesions on the ovaries and in the peritoneal cavity. The pathophysiology of this disease is poorly understood and our group has helped to elucidate certain mechanisms such as the role of oxidative stress (Ngo, Am J Pathol 2009, Marcellin FRBM 2017), the activation of MAP Kinase (Ngo, J Pathol 2010, Santulli, EOTT 2015, 2016) and the mTOR / Akt pathway (Leconte, Am J Pathol 2010). Our group is particularly interested in the different adaptive or innate components of the chronic inflammatory response that characterizes the disease (Santulli, Hum Reprod 2012, 2013, Fertil Steril 2012, JCEM 2014, Gonzalez-Foruria I, PloS One 2015, MHR 2017, Riccio Human Reprod 2019, Peyneau PNAS 2019). Our team conducts basic as well as translational and clinical research and is associated to the departments of gynecology, assisted medical procreation, reproductive biology and immunology.

     


    Team

    • Frédéric Batteux PUPH
    • Charles Chapron PUPH
    • Sandrine Chouzenoux, Technicienne
    • Ludivine Doridot MCF
    • Mohamed Jeljeli AHU
    • Carole Nicco, IR1 Université de Paris
    • Pietro Santulli PUPH
    • Thierry Tchénio CR1 INSERM
    • Marine Thomas, Adjoint technique

     

    Main publications :

    1: Peyneau M, Kavian N, Chouzenoux S, Nicco C, Toullec L, Reboul-Marty J, Chenevier-Gobeaux C, Jeljeli M, Reis FM, Santulli P, Doridot L, Chapron C, Batteux F. Role of thyroid hormones and dyimmunity in endometriosis. Proc Natl Acad Sci U S A. 2019 In press.

    2: Riccio LGC, Jeljeli M, Santulli P, Chouzenoux S, Doridot L, Nicco C, Reis FM, Abrão MS, Chapron C, Batteux F. B Lymphocytes inactivation by ibrutinib limits endometriosis progression in mice. Hum Reprod. 2019 In press. 

    3: Maignien C, Santulli P, Chouzenoux S, Gonzalez-Foruria I, Marcellin L, Doridot L, Jeljeli M, Grange P, Reis FM, Chapron C, Batteux F. Reduced α-2,6 sialylation  regulates cell migration in endometriosis. Hum Reprod. 2019 Mar 1;34(3):479-490. 

    4: González-Foruria I, Santulli P, Chouzenoux S, Carmona F, Chapron C, Batteux F. Dysregulation of the ADAM17/Notch signalling pathways in endometriosis: from oxidative stress to fibrosis. Mol Hum Reprod. 2017 Jul 1;23(7):488-499.

    5: Marcellin L, Santulli P, Chouzenoux S, Cerles O, Nicco C, Dousset B, Pallardy  M, Kerdine-Römer S, Just PA, Chapron C, Batteux F. Alteration of Nrf2 and Glutamate Cysteine Ligase expression contribute to lesions growth and fibrogenesis in ectopic endometriosis. Free Radic Biol Med. 2017 Sep;110:1-10.

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