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    Team: Dynamics of T cell interactions

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    Team leaders

     

    The team in brief… Our team investigates the mechanisms whereby T cells trigger an immune response in physiological and pathological conditions including in cancers. We are particularly interested in the capacity of T cells to migrate and to recognize a foreign antigen. To address these issues, we make an extensive use of dynamic imaging microscopy.

     

    Objectives

    Research conducted in our team is centered in studying T cell activation and migration with approaches ranging from molecular and cellular levels to more integrated systems. For this purpose, we have developed new tools based on fluorescence microscopy that has always been important in our experimental approaches. Precisely, we intend to understand the early signaling events and the molecular partners underlying T cell migration and activation.  We are also interested in defining the role played by the PI3K/FoxO pathway in T cell homeostasis and differentiation. The characterization of new FoxO targets represents an important aspect of our work too. Over the last years, we have taken advantage of our experience with T cells in vitro to address questions related to the behavior of these cells in ex-vivo conditions in normal lymphoid tissues and tumors, with a particular focusing on mechanisms by which human tumors escape T cell attacks. More recently, we have initiated a new project that aims to identify the cross-talk between the immune system and the nervous system during cancer development. Finally, we are exploring, in time and space, how a successful immune response triggered by various immunotherapy protocols leads to tumor regression.

    Equipe Donnadieu-Randriamampita

     

    Main publications

    • Peranzoni E, Rivas-Caicedo A, Bougherara H, Salmon H, Donnadieu E. Positive and negative influence of the matrix architecture on antitumor immune surveillance. Cell Mol Life Sci. 2013; 70(23):4431-48. 
    • Rougerie,P., Largeteau, Q., Megrelis,L., Carrette, F., Lejeune,T., Toffali, L., Rossi, B., Zeghouf, M., Cherfils, J., Constantin, G., Laudanna, C., Bismuth, G., Mangeney, M., Delon, J. Fam65b is a new transcriptional target of FOXO1 that regulates RhoA signaling for T lymphocyte migration. J Immunol 2013 190(2):748-755
    • Salmon, H., K. Franciszkiewicz, D. Damotte, M.C. Dieu-Nosjean, P. Validire, A. Trautmann, F. Mami-Chouaib, and E. Donnadieu. Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors. J Clin Invest. 2012; 122:899-910. 
    • Wang, S. F., Fouquet, S., Chapon, M., Salmon, H., Regnier, F., Labroquere, K., Badoual, C., Damotte, D., Validire, P., Maubec, E., Delongchamps, N. B., Cazes, A., Gibault, L., Garcette, M., Dieu-Nosjean, M. C., Zerbib, M., Avril, M. F., Prevost-Blondel, A., Randriamampita, C., Trautmann, A., Bercovici, N. Early T Cell Signalling Is Reversibly Altered in PD-1 T Lymphocytes Infiltrating Human Tumors PLoS One 2011; 6(3):e17621
    • Conche, C., Boulla, G., Trautmann, A., Randriamampita, C. T cell adhesion primes antigen receptor-induced calcium responses through a transient rise in adenosine 3',5'-cyclic monophosphate Immunity 2009; 30(1):33-43

     

     

    Team’s news

    • The recognition and the funding of the team as «Equipe de la Ligue Nationale contre le Cancer» have been renewed in 2014.
    • Laureate of the Fondation Tourre-Necker Prize: Céline Charvet (2013)
    • Laureate of the Cochin graduate Prize: Laura Megrelis (2014), Chloé Guedj (2013), Pablo Rougerie (2011).
    • Laureate of the CNRS silver medal: Alain Trautmann (2011).
    • The team is a member of the SIRIC (a cancer research network) CARPEM, a program which gathers scientists and clinicians from several centers including Cochin and HEGP hospitals
    • The team actively participates to the Apprenti-Chercheur Program for several years in collaboration with the Arbre des Connaissances association.
    •  Georges Bismuth is head of the University Paris Descartes Foundation
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