Biomedical research institute
Biomedical research institute
 | Florence Niedergang DR1 CNRS |
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Phagocytosis is the mechanism of capture and degradation of pathogens or debris that is performed by professional cells of the immune system. In certain circumstances, this process is impaired, which can lead to the development of opportunistic pathogens or chronic inflammation. We study the mechanims of capture and degradation by phagocytic cells, their impact on immune responses and their alterations by viral infections, in the context of the development of bacterial co-infections or more recently in the cross-talk between microglia and neurons. |
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Professional phagocytes play a major role in innate and adaptive immune responses. Phagocytosis and degradation of invading microorganisms or debris is crucial for bacterial clearance and resolution of inflammation. Therefore, it is crucial to understand the mechanisms of phagocytosis, especially of cell debris or microorganisms.
Our first goal is to dissect the mechanisms used by phagocytes, in particular the coordinated activities of signaling pathways, membrane trafficking and cytoskeleton dynamics, and their effect on the outcome of immune responses with a special focus on the interferon-beta response. Second, we analyze how viruses, including HIV-1 infection or respiratory viruses associated with lung inflammation, impair the phagocytic and clearance functions. Third, we study the interferon -beta response and microglia phagocytosis in neuronal response to viral infection. Finally, we explore how dendritic cells regurgitate non-degraded material to activate B cells in order to manipulate the humoral immune response.
Jubrail, J., Africano-Gomez, K., Herit, F., Mularski, A., Bourdoncle, P., Oberg, L, Israelsson, E., Burgel, P-R., Mayer, G., Mootoosamy Cunoosamy, D., Kurian, N., and Niedergang F. Arpin is critical for phagocytosis in macrophages and is targeted by human rhinovirus. EMBO Rep. (2019). e47963. doi: 10.15252/embr.201947963
Boncompain G, Herit F, Tessier S, […], Brelot A, Niedergang F, Perez F. Differential screening identifies molecules specifically inhibiting CCR5 transport to the cell surface and HIV infection. bioRxiv. Doi.org/10.101364927. Science Advances (2019); 5: eaax0821. doi: 10.1126/sciadv.aax0821
Niedergang F. Dendritic cells mature to resist lamin degradation and herpes virus release. J. Cell Biol. (2019). 4;218(2):387-388. doi: 10.1083/jcb.201812051.
Jubrail, J., Africano-Gomez, K., Herit, F., Baturcam, E., Mayer, E., Mootoosamy Cunoosamy, D., Kurian, N., and Niedergang, F. HRV16 impairs macrophages cytokine response to a secondary bacterial trigger. Front. Immunol. (2018) 9:2908
Lê-Bury G and Niedergang F Defective phagocytic properties of HIV-infected macrophages: how might they be implicated in the development of invasive Salmonella Typhimurium ? Front. Immunol. (2018) 9:531
Niedergang, F. and Grinstein, S. How to build a phagosome: new concepts for an old process. Curr Op Cell Biol (2018) 50:57-63
Jubrail, J., Kurian, N. and Niedergang, F. Macrophage phagocytosis cracking the defect code in COPD. Biomedical J. (2017) 40 : 305-312
Marie-Anaïs F, Mazzolini J, Herit F and Niedergang F. Dynamin-actin cross-talk contributes to phagosome formation and closure. Traffic (2016) 17 : 487-499.Dumas A, Lê‑Bury G, Marie‑Anaïs F, Herit F, Mazzolini J, Guilbert T, Bourdoncle P., Russell DG, Benichou S, Zahraoui A, and Niedergang F. The HIV-1 protein Vpr impairs phagosome maturation by controlling microtubule-dependent trafficking.
J. Cell Biol. (2015) 211 : 359-372
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