Biomedical research institute
Biomedical research institute
 | Florence Niedergang DR1 CNRS |
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Phagocytosis is the mechanism of capture and degradation of pathogens or debris that is performed by professional cells of the immune system. In certain circumstances, this process is impaired, which can lead to the development of opportunistic pathogens or chronic inflammation. We study the mechanims of capture and degradation by phagocytic cells, their impact on immune responses and their alterations by viral infections, leading to the development of bacterial co-infections. |
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Professional phagocytes play a major role in innate and adaptive immune responses. Phagocytosis and degradation of invading microorganisms or debris is crucial for bacterial clearance and resolution of inflammation. Therefore, it is crucial to understand the mechanisms of phagocytosis, especially of cell debris or microorganisms.
Our first goal is to dissect the mechanisms used by phagocytes, in particular the coordinated activities of signaling pathways, membrane trafficking and cytoskeleton dynamics, and their effect on the outcome of immune responses. Second, we analyze how HIV infection or respiratory viruses associated with lung inflammation impair the phagocytic functions. Finally, we will explore further how dendritic cells regurgitate non-degraded material to activate B cells in order to manipulate the humoral immune response.
Lê-Bury G and Niedergang F Defective phagocytic properties of HIV-infected macrophages: how might they be implicated in the development of invasive Salmonella Typhimurium ? Front. Immunol. (2018) 9:531
Niedergang, F. and Grinstein, S. How to build a phagosome: new concepts for an old process. Curr Op Cell Biol (2018) 50:57-63
Jubrail, J., Kurian, N. and Niedergang, F. Macrophage phagocytosis cracking the defect code in COPD. Biomedical J. (2017) 40 : 305-312
Marie-Anaïs F, Mazzolini J, Herit F and Niedergang F. Dynamin-actin cross-talk contributes to phagosome formation and closure. Traffic (2016) 17 : 487-499.Niedergang F., Phagocytosis. In: Ralph A Bradshaw and Philip D Stahl (Editors-in-Chief), Encyclopedia of Cell Biology, Vol 2, Waltham, MA: Academic Press, 2016, pp. 751-757.
Dumas A, Lê‑Bury G, Marie‑Anaïs F, Herit F, Mazzolini J, Guilbert T, Bourdoncle P., Russell DG, Benichou S, Zahraoui A, and Niedergang F. The HIV-1 protein Vpr impairs phagosome maturation by controlling microtubule-dependent trafficking.
J. Cell Biol. (2015) 211 : 359-372
Marion S., Mazzolini J., Herit F., Bourdoncle P., Kambou-Pene N., Hailfinger S., Sachse M., Benmerah A., Echard A., Thome M. and Niedergang F. The NF-κB signaling protein Bcl10 regulates actin dynamics by controlling AP1 and OCRL-bearing vesicles. Dev Cell (2012) 23 : 954-967.
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