Biomedical research institute
Biomedical research institute
Team leaders
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Claire Poyart |  |
Agnès Fouet |
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| The main goals of our research activity aim at defining molecular bases, at elucidating new pathways/mechanisms involved in the pathogenesis of Group A (GAS; Streptococcus pyogenes) and Group B (GBS; Streptococcus agalactiae) streptococcal infections. GAS is can cause a broad range of diseases, from pharyngitis to necrotizing fasciitis and toxic shock syndrome with an estimated 550,000 deaths yearly. GBS is the leading cause of neonate infections and an important cause of mortality and morbidity in the elderly or adults with underlying diseases |
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Our research is centered around Group A (GAS, Streptococcus pyogenes) and group B (GBS, Streptococcus agalactiae) Streptococcus infections. We carry out molecular epidemiology of the Streptococci studies and decipher the molecular mechanisms involved in the origin of strain evolution. Our research also aims at defining the molecular bases, at elucidating the factors and mechanisms involved in the pathogenesis of Group A streptococcus and Group B Streptococcus infections. Regarding GAS, our project aims at deciphering bacterial and host factors involved in invasive diseases and more precisely in the endometrial tropism of particular strains. As for GBS, our goal is to understand why a bacterium commensal for the adult is a formidable pathogen for the neonate. Furthermore, Claire Poyart heads, since 2006, the National Reference Center for Streptococci (CNR-Strep). The CNR-Strep collects strains responsible for invasive and non-invasive strains sent by a network of clinical laboratories with a nationwide distribution. All the strains are characterized at the molecular level and we can supply precise epidemiological data on GBS and GAS strains circulating in France.
Dinis M, Plainvert C, Longo M, Guignot J, Gabriel C, Poyart C, Fouet A. Group A Streptococcus emm3 strains induce early macrophage cell death. Pathog Dis. 2016 Mar;74(2). pii: ftv124.
Six A, Firon A, Plainvert C, Caplain C, Bouaboud A, Touak G, Dmytruk N, Longo M, Letourneur F, Fouet A, Trieu-Cuot P, Poyart C. Molecular Characterization of Nonhemolytic and Nonpigmented Group B Streptococci Responsible for Human Invasive Infections. J Clin Microbiol. 2016 Jan;54(1):75-82.
Six A, Bellais S, Bouaboud A, Fouet A, Gabriel C, Tazi A, Dramsi S, Trieu-Cuot P, Poyart C. Srr2, a multifaceted adhesin expressed by ST-17 hypervirulent Group B Streptococcus involved in binding to both fibrinogen and plasminogen. Mol Microbiol. 2015 Sep;97(6):1209-22.
Da Cunha V, Davies MR, Douarre PE, Rosinski-Chupin I, Margarit I, Spinali S, Perkins T, Lechat P, Dmytruk N, Sauvage E, Ma L, Romi B, Tichit M, Lopez-Sanchez MJ, Descorps-Declere S, Souche E, Buchrieser C, Trieu-Cuot P, Moszer I, Clermont D, Maione D, Bouchier C, McMillan DJ, Parkhill J, Telford JL, Dougan G, Walker MJ; DEVANI Consortium, Holden MT, Poyart C, Glaser P. Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline. Nat Commun. 2014 Aug 4;5:4544.
Bellais S, Six A, Fouet A, Longo M, Dmytruk N, Glaser P, Trieu-Cuot P, Poyart C. Capsular switching in group B Streptococcus CC17 hypervirulent clone: a future challenge for polysaccharide vaccine development. J Infect Dis. 2012 Dec 1;206(11):1745-52.