Biomedical research institute
     

    Publications

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    Roch B, Abramowski V, Chaumeil J, de Villartay J-P (2019). Cernunnos/Xlf results in suboptimal V(D)J recombination and impaired lymphoid development in mice. Frontiers Immunology, Accepted.

    SchiroliG, Conti A, Ferrari S, della Volpe L, Jacob A, Albano L, Beretta S, Calabria A, Vavassori V, Gasparini P, Salataj E, Ndiaye-Lobry D, Chaumeil J, Montini E, Merelli I, Genovese P, Naldini L, Di Micco R (2019) Precise Gene Editing Preserves Hematopoietic Stem Cell Function Following Transient p53-Mediated DNA Damage Response. Cell Stem Cell, accepted

    Barros de Andrade e Sousa L, Jonkers I, Syx L, Chaumeil J, Picard C, Foret B, Chen C-J, Lis JT, Heard E, Schulz EG, Marsico A. (2019) Kinetics of Xist-induced gene silencing can be predicted from combinations of epigenetic and genomic features. BioRxiv https://doi.org/10.1101/510198

    Souyris M, Mejia JE, Chaumeil J, Guéry JC. (2018) Female predisposition to TLR7-driven autoimmunity: gene dosage and the escape from X chromosome inactivation. Semin Immunopathol, https://doi.org/10.1007/s00281-018-0712-y

    Souyris M, Cenac C, Azar P, Daviaud D, Canivet A, Grunenwald S, Pienkowski C, Chaumeil J, Mejia JE, Guéry JC. (2018) TLR7 escapes from X chromosome inactivation in immune cells from women and Klinefelter syndrome men. Science Immunology, 3:eaap8855.

    Proudhon C, Hao B, Raviram R, Chaumeil J, Skok JA. (2015) Long-Range Regulation of V(D)J Recombination. Adv Immunol, 128:123-82.

    Chaumeil J, Micsinai M, Ntziachristos P, Roth DB, Aifantis I, Kluger Y, Deriano L, Skok JA. (2013) RAG2 C-terminus and ATM control RAG activity to limit the number of potential translocation substrates. Nature Comm, 31:4:2231.

    Rocha PP, Chaumeil J, Skok JA. (2013) Molecular Biology. Finding the right partner in a 3D genome. Science, 342(6164):133-4.

    Chaumeil J, Micsinai M, Ntziachristos P, Deriano L, Wang JMH, Ji Y, Nora E, Rodesch MJ, Jeddeloh JA, Kluger Y, Aifantis I, Schatz DG, Skok JA. (2013) Higher-order looping and nuclear organization of antigen receptor loci facilitates targeted RAG cleavage and regulated rearrangement in recombination centers. Cell Reports, 3(2):359-370. (‘Leading Edge’ in Cell, 2013;152(6); ‘Guest blog’ by A. Corcoran http://news.cell.com/cellreports/cell-reports/guest-blog-by-anne-corcoran)

    Chaumeil J, Skok JA. (2013) A new take on V(D)J recombination: transcription driven nuclear and chromatin reorganization in RAG-mediated cleavage. Front Immunol, 4:423.

    Chaumeil J, Micsinai M, Skok JA. (2013) Combined Immunofluorescence And DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization. J Vis Exp, 72. e50087.

    Johnson K, Chaumeil J, Micsinai M, Wang JMH, Ramsey LB, Baracho GV, Rickert RC, Strino F, Kluger Y, Farrar MA, Skok JA. (2012) IL-7 functionally segregates the pro-B cell stage by regulating transcription of recombination mediators across cell cycle. J Immunol, 188(12):6084-92.

    Deriano L, Chaumeil J, Coussens M, Multani A, Chou YF, Alekseyenko AV, Chang S, Skok JA, Roth DB. (2011) The RAG2 C terminus suppresses genomic instability and lymphomagenesis. Nature, 471(7336):119-23.