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    Role of soluble and contact factors during neuronal migration, axon outgrowth, and development of muscle masses.

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    We have previously analyzed the role of two distinct soluble factors during neuronal migration :

     

    - Netrin-1, a guidance factor initially discovered in the field of axon guidance, is able to guide neuronal migration, in particular for inferior olivary neurons (ref : Bloch-Gallego et al, 1999) ;

    - Netrin-1 and its dependence DCC and Unc-5H receptors are involved in the survival of precerebellar neurons in vivo ( ref: Llambi et al., 2001).

    - Slit, another diffusible molecule secreted by the floor-plate is able to mask netrin-1 effects (ref: Causeret et al., 2002).

    - The sensitivity of answers of  the various populations of precerebellar neurons differs, in terms of phenotypic consequences of expression alterations of guidance cues or of their receptors (Marcos et al., 2009a).

    We now further study receptors and partners involved in netrin-1 effects, and we characterize the role of netrin-1 in axon and cell bodies pathfinding in - or in the vicinity of - the ventral midline.

     

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