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    Neuronal development and motivity

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    Evelyne BLOCH-GALLEGO

     

    The team « Development and neuronal migration » directed by Evelyne Bloch-Gallego, has set up in Cochin Institute in July 2003, when supported by an « Avenir » award by INSERM. In January 2014, she has integrated the team directed by Pascal Maire et Athanassia Sotiropoulos to manage a project entitled "Neuronal development and motivity".

     

    We study molecular and cellular mechanisms involved in both normal and pathological development of the central nervous system, with a special care for abnormal neuronal migrations, axon outgrowth during embryogenesis, and also formation of mature neuronal pools and motoneuronal degenerescences in various mutant mice.

    As illustrate don the movie, through the example of the migration of precerebellar neurons that will form the inferior olivary nucleus, young postmitotic neurons migrate a long distance, from their birthpace at embryonic day E11 (E11) in the alar part of the hindbrain, to reach the floor plate ventrally from E13; then, a second migration (between E15 and birth) will allow the acquisition of the mature lamellated structure. This organization in sub-nuclei is required for axon projections to develop properly in respect to the correct topographic map of projections.

     

     

    Our research aims at:

    - studying diffusible factors and adhesion or matricellular molecules that direct axon outgrowth, neuronal migration and the organization and maintennace of neuronal pools.

    - studying intracellular reorganizations that are associated with the various steps to reach the mature organization of neuronal pools, during the development of the central nervous system, including central and peripheral synapses.

     

    A special care will be devoted to intracellular reorganizations that are associated with the settlement of precerebellar neurons (involved in motor learning) and bulbar motoneurons, as well as with motoneuronal degenerescence (Amyotrophic Lateral Sclerosis – ALS - and Spinal Muscular Atrophy – SMA).

     

    Studies developed in our team lays at the interface between developmental neurobiology and cell biology ( see Methodological approaches).