Biomedical research institute
     

    Gli transcription factors

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    Principal investigator : Jean-Paul CONCORDET

     

    Hedgehog signaling is a major signaling pathway in the vertebrate embryo. It is essential for the development of numerous cell types and organs and its dysregulation is involved in many developmental syndromes and cancers. At the molecular level, reponse to Hedgehog signals is mediated by the Gli transcription factors Gli1,-2,-3. We are interested in understanding the regulation of Gli transcription factor activity by Hedgehog signals using a combination of in vitro and in vivo approaches.