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    Normal and Pathological hematopoiesis

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    Team leaders

     

     

     

    Hematopoiesis is the biological process that allows production of all kind of blood cells. It stands all life-long. It relies on the presence of hematopoietic stem progenitor cells (HSPCs) that can be maintained as quiescent cells, can self-renew, proliferate or differentiate to generate any kind of blood cell sub-type depending on body needs. The team focuses its interests on factors that contribute to HSPC maintenance, to their commitment to produce red blood cells or megakaryocytes and platelets, and those whose dysregulation sustain leukemia and myelodysplastic syndromes in Humans.

     

     

     

     

    Research themes

     

     The team focuses its interest on the following areas:

    -        Characterization of regulatory processes involved in erythropoiesis (Theme 1)

    -        Regulators of hematopoietic stem and progenitor cell maintenance (Theme 2)

    -        Signaling pathways in myeloid leukemia (theme 3)

    -        Actors involved in myelodysplastic syndromes (Theme 4

    -        RINF epigenetic regulator and hematopoiesis (Theme 5)