Biomedical research institute
     

    Publications

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    Hegde, P., Weiss, E., Paradis, V., Wan, J., Mabire, M., Sukriti, S., Rautou, P. E., Albuquerque, M., Picq, O., Gupta, A. C., Ferrere, G., Gilgenkrantz, H., Kiaf, B., Toubal, A., Beaudoin, L., Letteron, P., Moreau, R., Lehuen*, A., Lotersztajn*, S. (*equal last authors) Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver Nat Commun 2018; 9(1):2146
    Luce S, Guinoiseau S, Gadault A, Letourneur F, Blondeau B, Nitschke P, Pasmant E, Vidaud M, Lemonnier F, Boitard C. A Humanized Mouse Model to Study Type 1 Diabetes.  Diabetes. 2018 Sep;67(9):1816-1829.

    Rouxel, O., Lehuen, A. Mucosal-associated invariant T cells in autoimmune and immune-mediated diseases Immunol Cell Biol 2018; 96(6):618-629

    Rouxel, O., Lehuen, A. [Mucosal-associated invariant T cells] Med Sci (Paris) 2018; 34(6-7):518-522

    Touch, S., Assmann, K. E., Aron-Wisnewsky, J., Marquet, F., Rouault, C., Fradet, M., Mosbah, H., Consortium, M., Isnard, R., Helft, G., Lehuen, A., Poitou, C., Clement, K., Andre, S., MetaCardis, Consortium Mucosal-associated invariant T (MAIT) cells are depleted and prone to apoptosis in cardiometabolic disorders FASEB J 2018; 32(9):5078-89

    Durgeau, A., Virk, Y., Gros, G., Voilin, E., Corgnac, S., Djenidi, F., Salmon, J., Adam, J., de Montpreville, V., Validire, P., Ferrone, S., Chouaib, S., Eggermont, A., Soria, J. C., Lemonnier, F., Tartour, E., Chaput, N., Besse, B., Mami-Chouaib, F. Human preprocalcitonin self-antigen generates TAP-dependent and -independent epitopes triggering optimised T-cell responses toward immune-escaped tumours Nat Commun 2018; 9(1):5097

    Schmitt, C.C., Aranias, T., Viel, T., Chateau, D., Le Gall, M, Waligora-Dupriet, A.-J., Melchior, C., Rouxel, O., Kapel, K., Gourcerol, G., Tavitian, B., Lehuen, A., Brot-Laroche, E., Leturque, A., Serradas, P., Grosfeld, A. Intestinal invalidation of the glucose transporter GLUT2 delays tissue distribution of glucose and reveals an unexpected role in gut homeostasis Molecular Metabolism 2017; 6(1):61-72

    Lebailly, B., Langa, F., Boitard, C., Avner, P., Rogner, U. C. The circadian gene Arntl2 on distal mouse chromosome 6 controls thymocyte apoptosis Mamm Genome 2017; 28(1-2):1-12

    Briet, C., Bourdenet, G., Rogner, U. C., Becourt, C., Tardivel, I., Drouot, L., Arnoult, C., do Rego, J. C., Prevot, N., Massaad, C., Boyer, O., Boitard, C. The Spontaneous Autoimmune Neuromyopathy in ICOSL-/- NOD Mice Is CD4+ T-Cell and Interferon-gamma Dependent Front Immunol 2017; 8:287

    Scheikl-Gatard, T., Tosch, C., Lemonnier, F., Rooke, R. Identification of new MUC1 epitopes using HLA-transgenic animals: implication for immunomonitoring J Transl Med 2017; 15(1):154

    Rouxel, O., Da Silva, J., Beaudoin, L., Nel, I., Tard, C., Cagninacci, L., Kiaf, B., Oshima, M., Diedisheim, M., Salou, M., Corbett, A., Rossjohn, J., McCluskey, J., Scharfmann, R., Battaglia, M., Polak, M., Lantz, O., Beltrand, J., Lehuen, A. Cytotoxic and regulatory roles of mucosal-associated invariant T cells in type 1 diabetes Nat Immunol 2017; 18(12):1321-1331

    Diedisheim, M., Mallone, R., Boitard, C., Larger, E. beta-cell Mass in Nondiabetic Autoantibody-Positive Subjects: An Analysis Based on the Network for Pancreatic Organ Donors Database J Clin Endocrinol Metab 2016; 101(4):1390-7

    Toubal, A., Lehuen, A. Lights on MAIT cells, a new immune player in liver diseases J Hepatol 2016; 64(5):1008-10

    Nel, I., Lehuen, A. Defective Invariant Natural Killer T-Cell Suppression in Patients With Type 1 Diabetes Diabetes 2016; 65(8):2121-3

    Perol, L., Lindner, J. M., Caudana, P., Nunez, N. G., Baeyens, A., Valle, A., Sedlik, C., Loirat, D., Boyer, O., Creange, A., Cohen, J. L., Rogner, U. C., Yamanouchi, J., Marchant, M., Leber, X. C., Scharenberg, M., Gagnerault, M. C., Mallone, R., Battaglia, M., Santamaria, P., Hartemann, A., Traggiai, E., Piaggio, E. Loss of immune tolerance to IL-2 in type 1 diabetes Nat Commun 2016; 7:13027

    Alzaid, F., Lagadec, F., Albuquerque, M., Ballaire, R., Orliaguet, L., Hainault, I., Blugeon, C., Lemoine, S., Lehuen, A., Saliba, D. G., Udalova, I. A., Paradis, V., Foufelle, F., Venteclef, N. IRF5 governs liver macrophage activation that promotes hepatic fibrosis in mice and humans JCI Insight 2016; 1(20):e88689

    Lehuen, A. A double-edged sword against type 1 diabetes N Engl J Med 2015; 372(8):778-80

    Magalhaes, I., Pingris, K., Poitou, C., Bessoles, S., Venteclef, N., Kiaf, B., Beaudoin, L., Da Silva, J., Allatif, O., Rossjohn, J., Kjer-Nielsen, L., McCluskey, J., Ledoux, S., Genser, L., Torcivia, A., Soudais, C., Lantz, O., Boitard, C., Aron-Wisnewsky, J., Larger, E., Clement, K., Lehuen, A. Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients J Clin Invest 2015; 125(4):1752-62

    Magalhaes, I., Kiaf, B., Lehuen, A. iNKT and MAIT Cell Alterations in Diabetes Front Immunol 2015; 6:341

    Lebailly, B., Boitard, C., Rogner, U. C. Circadian rhythm-related genes: implication in autoimmunity and type 1 diabetes Diabetes Obes Metab 2015; 17 Suppl 1:134-8

    Thorens, B., Accili, D., Ahren, B., Cerasi, E., Seino, S., Boitard, C. The Islet and Metabolism Keep Time Diabetes Obes Metab 2015; 17 Suppl 1:3-5

    Magalhaes, I., Lehuen, A. [Mucosal-associated invariant T cells in obesity and type 2 diabetes] Med Sci (Paris) 2015; 31(8-9):717-9

    Culina, S., Gupta, N., Boisgard, R., Afonso, G., Gagnerault, M. C., Dimitrov, J., Osterbye, T., Justesen, S., Luce, S., Attias, M., Kyewski, B., Buus, S., Wong, F. S., Lacroix-Desmazes, S., Mallone, R. Materno-Fetal Transfer of Preproinsulin Through the Neonatal Fc Receptor Prevents Autoimmune Diabetes Diabetes 2015; 64(10):3532-42

    Tard, C., Rouxel, O., Lehuen, A. Regulatory role of natural killer T cells in diabetes Biomed J 2015; 38(6):484-95

    Mars, L. T., Mas, M., Beaudoin, L., Bauer, J., Leite-de-Moraes, M., Lehuen, A., Bureau, J. F., Liblau, R. S. Invariant NKT Cells Regulate the CD8 T Cell Response during Theiler's Virus Infection . PLoS ONE 2014; 9(1):e87717

    Ghazarian, L., Simoni, Y., Magalhaes, I., Lehuen, A. Invariant NKT cell development: focus on NOD mice Curr Opin Immunol 2014; 27C:83-88

    Beaudoin, L., Diana, J., Ghazarian, L., Simoni, Y., Boitard, C., Lehuen, A. Plasmacytoid dendritic cells license regulatory T cells, upon iNKT-cell stimulation, to prevent autoimmune diabetes Eur J Immunol 2014; 44(5):1454-66

    Li, S., Joseph, C., Becourt, C., Klibi, J., Luce, S., Dubois-Laforgue, D., Larger, E., Boitard, C., Benlagha, K. Potential Role of IL-17-Producing iNKT Cells in Type 1 Diabetes PLoS One 2014; 9(4):e96151

    Diana, J., Lehuen, A. Macrophages and beta-cells are responsible for CXCR2-mediated neutrophil infiltration of the pancreas during autoimmune diabetes EMBO Mol Med 2014; 6(8):1090-104

    Samandary, S., Kridane-Miledi, H., Sandoval, J. S., Choudhury, Z., Langa-Vives, F., Spencer, D., Chentoufi, A. A., Lemonnier, F. A., BenMohamed, L. Associations of HLA-A, HLA-B and HLA-C alleles frequency with prevalence of herpes simplex virus infections and diseases across global populations: Implication for the development of an universal CD8(+) T-cell epitope-based vaccine Hum Immunol 2014; 75(8):715-29

    Mkaddem, S. B., Christou, I., Rossato, E., Berthelot, L., Lehuen, A., Monteiro, R. C. IgA, IgA Receptors, and Their Anti-inflammatory Properties Curr Top Microbiol Immunol 2014; 382:221-35

    Accili, D., Ahren, B., Boitard, C., Seino, S., Thorens, B., Cerasi, E. The mind and the belly: a glance at how the nervous system directs metabolism Diabetes Obes Metab 2014; 16 Suppl 1:1-3

    Rasmussen, M., Harndahl, M., Stryhn, A., Boucherma, R., Nielsen, L. L., Lemonnier, F. A., Nielsen, M., Buus, S. Uncovering the Peptide-Binding Specificities of HLA-C: A General Strategy To Determine the Specificity of Any MHC Class I Molecule J Immunol 2014; 193(10):4790-802

    Kikkas, I., Mallone, R., Tubiana-Rufi, N., Chevenne, D., Carel, J. C., Creminon, C., Volland, H., Boitard, C., Morel, N. A Simple and Fast Non-Radioactive Bridging Immunoassay for Insulin Autoantibodies . PLoS One 2013; 8(7):e69021

    Boucherma, R., Kridane-Miledi, H., Bouziat, R., Rasmussen, M., Gatard, T., Langa-Vives, F., Lemercier, B., Lim, A., Berard, M., Benmohamed, L., Buus, S., Rooke, R., Lemonnier, F. A. HLA-A*01:03, HLA-A*24:02, HLA-B*08:01, HLA-B*27:05, HLA-B*35:01, HLA-B*44:02, and HLA-C*07:01 Monochain Transgenic/H-2 Class I Null Mice: Novel Versatile Preclinical Models of Human T Cell Responses J Immunol 2013; 191(2):583-93

    Diana, J., Moura, I. C., Vaugier, C., Gestin, A., Tissandie, E., Beaudoin, L., Corthesy, B., Hocini, H., Lehuen, A., Monteiro, R. C. Secretory IgA Induces Tolerogenic Dendritic Cells through SIGNR1 Dampening Autoimmunity in Mice J Immunol 2013; 191(5):2335-43

    Ghazarian, L., Simoni, Y., Pingris, K., Beaudoin, L., Lehuen, A. [Regulatory role of NKT cells in the prevention of type 1 diabetes] Med Sci (Paris) 2013; 29(8-9):722-8

    Luce, S., Briet, C., Becourt, C., Lemonnier, F., Boitard, C. The targeting of β-cells by T lymphocytes in human type 1 diabetes: clinical perspectives. Diabetes, Obesity and metabolism 2013; 15(s3):89-97

    Boitard, C. T-lymphocyte recognition of beta cells in type 1 diabetes: Clinical perspectives Diabetes Metab 2013; 39(6):459-66

    Ghazarian, L., Diana, J., Beaudoin, L., Larsson, P. G., Puri, R. K., van Rooijen, N., Flodstrom-Tullberg, M., Lehuen, A. Protection Against Type 1 Diabetes Upon Coxsackievirus B4 Infection and iNKT-Cell Stimulation: Role of Suppressive Macrophages Diabetes 2013; 62(11):3785-96

    Diana J, Simoni Y, Furio L, Beaudoin L, Agerberth B, Barrat F, Lehuen A. Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes. Nat Med. 2013 Jan;19(1):65-73.