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    New AIDS treatment strategy: Activate the HIV virus in reservoirs to better destroy it

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    A study directed by Georges Bismuth and Marianne Mangeney

    HIV persists in the body despite treatments by hiding in an inactive form in a very small fraction of the immune cells that it infects, particularly CD4 T cells. Thus, it escapes surveillance of the immune system and antiretroviral treatments that only act on an active virus. Georges Bismuth and Marianne Mangeney, in an article published on May 1, 2019 in Plos Pathogens and supported by the ANRS, show that the pharmacological inhibition of a regulator of the expression of many genes in T lymphocytes (called FOXO1) is able to reactivate HIV in these cells, with the hope of a new therapeutic strategy, called "shock and kill", aimed at eradicating the virus.

    For further information, read the ANRS press release

     

    Figure legend

    Reactivation of HIV by a pharmacological inhibitor of FOXO1

     

    Reference

    FOXO1 transcription factor plays a key role in T cell—HIV-1 interaction. Arthur Roux, Héloise Leroy, Bénédicte De Muylder, Lucie Bracq, Samia Oussous, Isabelle Dusanter-Fourt, Ghina Chougui, Rachida Tacine, Clotilde Randriamampita, Delphine Desjardins, Roger Le Grand, Frederic Bouillaud, Serge Benichou, Florence Margottin-Goguet, Remi Cheynier, Georges Bismuth, Marianne Mangeney. PLoS Pathog 15(5): e1007669, 2019.

     

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