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    Resarch at he Cochin Institute: the scientific departments

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    The department of Endocrinology, metabolism and cancer (EMC) includes 8 teams which main interests focus on energy metabolism, gene regulation in response to hormonal developmental and nutritional stimuli (insulin, glucose, iron, hypoxia) and in cellular signaling transduction in adrenal cortex, pancreas and liver. These main axes will allow to decipher the mechanisms involved in the physiopathology of metabolic disorders such as diabetes, obesity and endocrine tumors and to develop novel therapeutic strategies. It has been reinforced in 2012 by the arrival of two teams devoted respectively to the immunology of diatetes immunity and the control of pancreatic endocrine cell development. Most of the teams are involved in high competitivity labellized networks such as Labexes (Laboratoires d’excellence) “Who Am I", "GrEx"; « Siric » (integrated Cancer Research Site).

    The departement Development, Reproduction and Cancer (DRC) includes 9 teams whose scientific interests synergistically converge on the study of molecular and cellular mechanisms that regulate proliferation, differentiation, morphogenesis and function both in development and in specific pathological conditions suchas oncogenesis.This Department has a strong and long standing pioneering tradition in Genetics, Development, Epigenetics and Physiopathology. Our studies have very strong connections to many areas of human health and diseases including developmental disorders, inflammation, cancer, infertility and neurodevelopmental disorders. These connections are attested by the tight and proficient interactions that the teams of the Department have with the Medical School of “Paris Descartes” University and particularly with Cochin Hospital, Maternité Port-Royal and Necker Medical Center. Our teams have a strong international visibility that is illustrated by the important number of European networks grants and their belonging to prestigious consortia such as Labex (Laboratoires d’Excellence) including “Who Am I”, “GrEX” ; “SIRIC” (integrated Cancer Research Site); DHU (Département Hospitalo-universitaire)  “Risks and pregnancy” .

    The department Infection, Immunity and Inflammation (3I) is composed by 15 teams. These teams tackle basic questions on the biology of cell populations of the innate and adaptive immune systems: (T cells, dendritic cells, macrophages, B cells and neutrophils) and on host-pathogen interactions (bacteria, parasites, retroviruses). In addition, these teams address questions directly related to diseases: cancer, autoimmune, inflammatory and infectious diseases. All teams are interested in inflammation, the process by which the immune system reacts to infections and injuries that can be subverted by pathogens or tumor cells for their growth and dissemination. Some of them develop vaccine strategies. Most of these teams  currently interact on questions from basic to applied topics and are involved in networks of excellence such as Labexes («Inflammex», «parafrap», «Ibeid», «Siric» (integrated Cancer Research Site) network and DHU (Département Hospitalo-universitaire) «Risks and pregnancy» attesting for their competitivity. Long-term translational research activity is an important strength of this Department.