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    From molecular insights into TCR signaling to rational design of novel CARs

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    Seminar Institut Cochin

    Thursday 19 December 2019 - 12:00 - Room conference Rosalind Franklin, 2nd floor

     


    Susana Minguet

    Lymphocyte Signalling laboratory, Department of Immunology,
    University of Freiburg, Germany

     
     invited by Emmanuel Donnadieu

    Institut Cochin, 22 rue Méchain, 75014 Paris

     

    Abstract

    Our work is centered in understanding the molecular mechanisms leading to the activation of T and B lymphocytes. One of the main focuses of our group is to find out how T lymphocytes transmit the information of ligand binding to their antigen receptors across the plasma membrane and which signaling mechanisms regulate activation. We are motivated by the translational and synthetic applications of this knowledge, with special focus in the complex interplay between the biophysical properties of the extracellular matrix and T cell motility to improve tumor immunotherapy against cancer.

     

    Some publications

    • Fiala GJ, Minguet S. 2018. Caveolin-1: The Unnoticed Player in TCR and BCR Signaling. Adv Immunol. 137:83-133.
    • Minguet S§, Kläsener K, Schaffer AM, Fiala GJ, Osteso-Ibánez T, Raute K, Navarro-Lérida I, Hartl FA, Seidl M, Reth M, Del Pozo MA. 2017. Caveolin-1-dependent nanoscale organization of the BCR regulates B cell tolerance. Nat Immunol. 10:1150-1159. §Corresponding author.
    • Schamel WW, Alarcon B, Höfer T, Minguet S. 2017. The Allostery Model of TCR Regulation. J Immunol. 1:47-52.
    • Swamy, M, Beck-Garcia, K, Beck-Garcia, E, Hartl, FA, Morath, A, Yousefi, OS, Dopfer, EP, Molnar, E, Schulze, AK, Blanco, R, Borroto A, Martín-Blanco N, Alarcon B, Höfer T, Minguet S§ and Schamel WWA§. 2016. A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation. Immunity 44:1091-1101. §Shared corresponding author.

     

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