Biomedical research institute
     
    You are here: Home / Institute / Seminars and clubs / Immunosurveillance escape of senescent and cancer cells: a cause of age-associated diseases?

    Immunosurveillance escape of senescent and cancer cells: a cause of age-associated diseases?

    •  

    Seminar Institut Cochin

    Thursday 26 March 2020 - 12:00 - Room conference Rosalind Franklin, 2nd floor

     


    Julien Cherfils-Vicini

    IRCAN - Institute for the Recherche of Cancer and Aging, Nice, France

     
     invited by Frédéric Pendino

    Institut Cochin, 22 rue Méchain, 75014 Paris

     

    Abstract

    As we age, senescent cells accumulate in our tissues and alter the normal function of organs. By accumulating, they contribute to pathological ageing by promoting cancer and chronic diseases linked to à (pulmonary fibrosis, diabetes, Alzheimer...). Among stresses that trigger cellular senescence, unrelenting shortening of the DNA forming the chromosome extremities appears to play a key role. TRF2, a key telomeric protein that prevents cells to enter senescence, is down regulated during replicative senescence. We recently revealed that TRF2 over-expression in cancer cells (gastric, lung, colorectal, breast cancer among others) leads a non-cell autonomous mechanism favoring angiogenesis (Zizza et al., Nuc. Ac. Res 2019) and preventing the recruitment and the activation of NK cells (Biroccio*, Cherfils-Vicini* et al., Nat Cel. Biol 2013; Cherfils-Vicini et al., EMBO 2019) by triggering immunosuppression (MDSC and Tregs) by a TRF2 dependent heparan-sulfate proteoglycans (HSPG) (HS3ST4, VCAN, GPC-6) mechanisms. Altogether, these data reveal a link between telomere, glycocalyx and immunity. Strikingly, we recently revealed that a strong remodeling of glycocalyx at senescence can confer immune suppressive properties to senescent cells, favoring thus their accumulations within tissues and making a link with lung fibrosis in mouse models. Understanding how these cells accumulate as we age would allow the development of new therapeutic strategies to fight against age-related diseases and cancer.

     

     

    Message for people not personnal to the Cochin Institute who wish to come to listen to Julien Cherfils-Vicini:
    thank you to send your name, surname and professionnal address by mail to