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    Mechanics of blastocyst morphogenesis

    Webinar Institut Cochin

    Thursday 6 January 2022 - 12:00 - To obtain the Zoom access link, send an email to 

     


    Jean-Léon MAITRE

    Unit "Genetics and developmental biology", Institut Curie, Paris

     

     invited by Catherine PATRAT

     

    Abstract

    During pre-implantation development, the mammalian embryo forms the blastocyst. The architecture of the blastocyst is essential to the specification of the first mammalian lineages and to the implantation of the embryo. Consisting of an epithelium enveloping a fluid-filled lumen and the inner cell mass, the blastocyst is sculpted by a succession of morphogenetic events. These deformations result from the changes in the forces and mechanical properties of the tissue composing the embryo. Combining microscopy, image analysis, biophysical tools and genetics, we study the mechanical and cellular changes leading to the formation of the blastocyst. In particular, we uncover the distinct mechanical strategies adopted by human and mouse embryos to become compacted and how spindle instabilities can trigger cell fragmentation.