Biomedical research institute
     
    You are here: Home / Institute / Seminars and clubs / P-Bodies: cytosolic droplets for the storage of mRNA encoding regulating proteins

    P-Bodies: cytosolic droplets for the storage of mRNA encoding regulating proteins

    •  

    Seminar Institut Cochin

    Thursday 5 September 2019 - 12:00 - Room conference Rosalind Franklin, 2nd floor

     


    Dominique Weil

    Laboratory of Developmental Biology,
    Institute of Biology Paris-Seine, Paris, France

     
     invited by Isabelle Dusanter & Evelyne Lauret

    Institut Cochin, 22 rue Méchain, 75014 Paris

     

    Abstract

    Gene expression depends on the balance between RNA synthesis, decay and translation. In eukaryotes, RNAs and their associated proteins can condensate into cytoplasmic membrane-less organelles called P-bodies. Following the purification of P-bodies from human cells, we could show that they are primarily involved in the coordinated storage of poorly translated mRNAs. While these mRNAs encode a large variety of proteins, they tend to have regulatory functions. Combining this dataset with various transcriptomic analysis leads us to propose an integrative model of post-transcriptional regulation, where GC content plays a key role in coordinating an coherent but nevertheless adaptable gene expression program.

     

     

    Message for people not personnal to the Cochin Institute who wish to come to listen to Dominique Weil:
    thank you to send your name, surname and professionnal address by mail to