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    Platelets from HIV-infected individuals on suppressive antiretroviral therapy harbor infectious HIV predicting poor CD4+ T cell recovery

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    Seminar Institut Cochin

    Thursday 5 March 2020 - 12:00 - Room conference Rosalind Franklin, 2nd floor

     


    Fernando Real

    Institut Cochin, Paris

     
     invited by Morgane Bomsel

    Institut Cochin, 22 rue Méchain, 75014 Paris

     

    Abstract

    Beside hemostasis, human platelets exert several immune functions and interact with infectious pathogens including HIV in vitro. We found that platelets from HIV-infected patients shelter infectious HIV in vivo, despite successful viral suppression by antiretroviral drug therapy (ART). Moreover, >80% of virally suppressed HIV-infected individuals on ART sheltering, not those lacking, HIV in platelets fail to restore immunocompetent peripheral CD4+ T cell counts over 1 year of treatment. Altogether, platelets carrying HIV establish an alternative pathway for HIV dissemination in HIV-infected individuals on ART in correlation with immunological failure, opening treatment strategies, currently not available, to restore a competent immune status.

     

     

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