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    Signal integration during immune cell migration


    Seminar Institut Cochin

    Monday 1st July 2019 - 12:00 - Room conference Rosalind Franklin, 2nd floor


    Pablo J. Saez

    UMR 144, Institut Curie, Paris


     invited by Emmanuel Donnadieu

    Institut Cochin, 22 rue Méchain, 75014 Paris



     Migration of leukocytes, including dendritic cells (DCs), is a key process that determines the outcome of the immune response. To efficiently migrate, DCs quickly adapt to the dynamic properties of the micro-environment. This adaptation occurs due to high cellular plasticity, which allows fast integration of chemical and physical cues. Combining live imaging with new microfluidic devices that mimic 3D interstitial DC chemotaxis inside collagen gels, we analyzed the phenomenon of decision making when DCs face bifurcations and obstacles. In addition, we evaluated the intracellular distribution of several organelles and cytoskeletal components during DC chemotaxis.


    Some publications

    • ATP promotes the fast migration of dendritic cells through the activity of pannexin 1 channels and P2X7 receptors.
      Sáez PJ, Vargas P, Shoji KF, Harcha PA, Lennon-Duménil AM, Sáez JC.
      Sci Signal. 2017
    • Lysosome signaling controls the migration of dendritic cells.
      Bretou M, Sáez PJ, Sanséau D, Maurin M, Lankar D, Chabaud M, Spampanato C, Malbec O, Barbier L, Muallem S, Maiuri P, Ballabio A, Helft J, Piel M, Vargas P, Lennon-Duménil AM.
      Sci Immunol. 2017
    • Leukocyte Migration and Deformation in Collagen Gels and Microfabricated Constrictions.
      Sáez PJ, Barbier L, Attia R, Thiam HR, Piel M, Vargas P.
      Methods Mol Biol. 2018
    • Role of calcium permeable channels in dendritic cell migration.
      Sáez PJ, Sáez JC, Lennon-Duménil AM, Vargas P.
      Curr Opin Immunol. 2018
    • Myosin II Activity Is Selectively Needed for Migration in Highly Confined Microenvironments in Mature Dendritic Cells.
      Barbier L, Sáez PJ, Attia R, Lennon-Duménil AM, Lavi I, Piel M, Vargas P.
      Front Immunol. 2019



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