Institut de recherche biomédicale
     

    Offres d'emploi

    Post-doctoral position

    - Identification and characterization of new cellular factors involved in HIV-1 transcriptome regulation

    A post-doctoral position is available in the laboratory of host-virus interactions at the Institut Cochin, Paris. This opening is funded by the ANRS (Agence Nationale de Recherche sur le SIDA et les Hépatites Virales).

    Alternative splicing is a highly dynamic process and it is becoming increasingly apparent that its regulation is much more complicated than previously anticipated, involving multiple layers of regulation. The aim of this project is to further elucidate new factors/pathways that modulate the dynamic of HIV-1 transcriptome during its replication. The project will rely on a large-scale screening (CRISPR-Cas9) and a combination of cellular, molecular and viral approaches, as well as long read-sequencing analyses to identify and characterize novel actors involved in the regulation of HIV-1 alternative splicing and replication.

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    - Contribution of Autophagy proteins in HIV replication

    A postdoctoral position is available in the laboratory of Dr. Clarisse Berlioz-Torrent at the Institut Cochin in Paris. This opening is funded by the ANRS (Agence Nationale de Recherche sur le SIDA et les Hépatites Virales). With more than 700000 deaths due to this infection in 2019, HIV-1 is still a major global public health issue. It is therefore crucial to better characterize the interactions with cellular proteins that govern the replication cycle of HIV-1 in order to propose new therapeutic targets. In line with our ongoing work, the candidate will identify cellular cofactors required for HIV dissemination, related to non-canonical function of ATG proteins. 

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