Institut de recherche biomédicale
     
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    Equipe : Biology of Phagocytes

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     Responsable


    CV Aviesan

    Phagocytosis is the mechanism of capture and degradation of pathogens or debris that is performed by professional cells of the immune system. In certain circumstances, this process is impaired, which can lead to the development of opportunistic pathogens or chronic inflammation. We study the mechanims of capture and degradation by phagocytic cells, their impact on immune responses and their alterations by viral infections, leading to the development of bacterial co-infections.

     

    Objectives

    Professional phagocytes play a major role in innate and adaptive immune responses. Phagocytosis and degradation of invading microorganisms or debris is crucial for bacterial clearance and resolution of inflammation. Therefore, it is crucial to understand the mechanisms of phagocytosis, especially of cell debris or microorganisms.

    Our first goal is to dissect the mechanisms used by phagocytes, in particular the coordinated activities of signaling pathways, membrane trafficking and cytoskeleton dynamics, and their effect on the outcome of immune responses. Second, we analyze how HIV infection or respiratory viruses associated with lung inflammation impair the phagocytic functions. Finally, we will explore further how dendritic cells regurgitate non-degraded material to activate B cells in order to manipulate the humoral immune response.

     

    Main publications :

     

    Jubrail, J., Kurian, N. and Niedergang, F. Macrophage phagocytosis cracking the defect code in COPD. Biomedical J. (2017) In press

    Marie-Anaïs F, Mazzolini J, Herit F and Niedergang F. Dynamin-actin cross-talk contributes to phagosome formation and closure. Traffic (2016) 17 : 487-499.

    Niedergang F., Phagocytosis. In: Ralph A Bradshaw and Philip D Stahl (Editors-in-Chief), Encyclopedia of Cell Biology, Vol 2, Waltham, MA: Academic Press, 2016, pp. 751-757.

    Dumas A, Lê‑Bury G, Marie‑Anaïs F, Herit F, Mazzolini J, Guilbert T, Bourdoncle P., Russell DG, Benichou S,  Zahraoui A,  and Niedergang F. The HIV-1 protein Vpr impairs phagosome maturation by controlling microtubule-dependent trafficking.
    J. Cell Biol. (2015) 211 : 359-372

    Marion S., Mazzolini J., Herit F., Bourdoncle P., Kambou-Pene N., Hailfinger S., Sachse M., Benmerah A., Echard A., Thome M. and Niedergang F. The NF-κB signaling protein Bcl10 regulates actin dynamics by controlling AP1 and OCRL-bearing vesicles. Dev Cell (2012) 23 : 954-967.

     

    Team's news

     

    • Our 2016 Traffic paper on phagosome closure was highlighted on the CNRS website
    • Thierry Lhermitte who supports the Fondation pour la Recherche Medicale, visited the lab in March 2016. The interview came out in Paris Match.
    • The team obtained the « Equipe FRM » (Team FRM) label from Fondation pour la Recherche Médicale (2013-2017).