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    Equipe : Biologie des Phagocytes, infection et immunité

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     Responsable


    CV Aviesan

    Phagocytosis is the mechanism of capture and degradation of pathogens or debris that is performed by professional cells of the immune system. In certain circumstances, this process is impaired, which can lead to the development of opportunistic pathogens or chronic inflammation. We study the mechanims of capture and degradation by phagocytic cells, their impact on immune responses and their alterations by viral infections, leading to the development of bacterial co-infections.

     

    Objectives

    Professional phagocytes play a major role in innate and adaptive immune responses. Phagocytosis and degradation of invading microorganisms or debris is crucial for bacterial clearance and resolution of inflammation. Therefore, it is crucial to understand the mechanisms of phagocytosis, especially of cell debris or microorganisms.

    Our first goal is to dissect the mechanisms used by phagocytes, in particular the coordinated activities of signaling pathways, membrane trafficking and cytoskeleton dynamics, and their effect on the outcome of immune responses. Second, we analyze how HIV infection or respiratory viruses associated with lung inflammation impair the phagocytic functions. Finally, we will explore further how dendritic cells regurgitate non-degraded material to activate B cells in order to manipulate the humoral immune response.

     

     

    Main publications :

    Jubrail, J., Africano-Gomez, K., Herit, F., Baturcam, E., Mayer, E., Mootoosamy Cunoosamy, D., Kurian, N., and Niedergang, F. HRV16 impairs macrophages cytokine response to a secondary bacterial trigger. Frontiers in immunology (2018) 9:2908

    Mularski A, Marie-Anaïs F, Mazzolini J, Niedergang F. Observing Frustrated Phagocytosis and Phagosome Formation and Closure Using Total Internal Reflection Fluorescence Microscopy (TIRFM). Methods Mol Biol. (2018);1784:165-175

    Lê-Bury G and Niedergang F Defective phagocytic properties of HIV-infected macrophages: how might they be implicated in the development of invasive Salmonella Typhimurium ? Front. Immunol. (2018) 9:531

    Niedergang, F. and Grinstein, S. How to build a phagosome: new concepts for an old process. Curr Op Cell Biol  (2018) 50:57-63

    Jubrail, J., Kurian, N. and Niedergang, F. Macrophage phagocytosis cracking the defect code in COPD. Biomedical J. (2017) 40 : 305-312

    Marie-Anaïs F, Mazzolini J, Herit F and Niedergang F. Dynamin-actin cross-talk contributes to phagosome formation and closure. Traffic (2016) 17 : 487-499.

    Dumas A, Lê‑Bury G, Marie‑Anaïs F, Herit F, Mazzolini J, Guilbert T, Bourdoncle P., Russell DG, Benichou S,  Zahraoui A,  and Niedergang F. The HIV-1 protein Vpr impairs phagosome maturation by controlling microtubule-dependent trafficking.
    J. Cell Biol. (2015) 211 : 359-372

    Marion S., Mazzolini J., Herit F., Bourdoncle P., Kambou-Pene N., Hailfinger S., Sachse M., Benmerah A., Echard A., Thome M. and Niedergang F. The NF-κB signaling protein Bcl10 regulates actin dynamics by controlling AP1 and OCRL-bearing vesicles. Dev Cell (2012) 23 : 954-967.

     

    Team's news

    •  Florence Niedergang was selected as visiting scientist in Argentina in 2019, hosted by Maria-Teresa Damiani in Mendoza
    • Anna Mularski attended her first ASCB / EMBO meeting in San Diego, supported by a travel grant from ITMO BCDE : congratulations !
    • Jamil Jubrail was awarded 1st prize for his presentation in a competition with other post-docs at the British Association of Lung Research Summer Meeting 2018, Birmingham, UK in September: congratulations!
    • Our manuscript on inhibition of CCR5 secretion and HIV infection is available on BioRXiv.You can access it and share it via https://www.biorxiv.org/content/early/2018/07/08/364927
    • Florence Niedergang co-organized the 3rd International Building the Cell meeting in Paris, September 26-28, 2018. http://www.atoutcom.com/btc2018/
    •  The lab has participated to the “Fête de la Science” event on October 12th for class visits and on October 13th for general public (activity “How sentinel immune cells are hijacked by microbes”)
    • Florence Niedergang and Jamil Jubrail organized the 8th Institut Cochin Miltenyi symposium on « Respiratory diseases » on November17, 2017 https://institutcochin.fr/animation/symposium

     

     

     

     

     

     

     

     

     

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