Institut de recherche biomédicale


    Scientific production (from 2012)


    Roux A, Bracq  L, De Muylder B, Leroy H, Oussous S, Dusanter-Fourt I, Chougui G, Tacine R, Randriamampita C, Desjardins D, Le Grand R, Bouillaud F, Benichou S, Margottin-Goguet F, Cheynier R, Bismuth G & Mangeney M. FOXO1 transcription factor plays a key role in T cell – HIV-1 interaction. PlosPathogens. Sous presse.

    Megrelis, L., El Ghoul, E., Moalli, F., Versapuech, M., Cassim, S., Ruef, N., Stein, J.V., Mangeney, M. and Delon J. (2018) Fam65b phosphorylation relieves tonic RhoA inhibition during T cell migration. Front Immunol. 9:2001

    Raynaud-Messina, B., Bracq, L., Dupont, M., Souriant, S., Usmani, S. Proag, A., Pingris, K., Soldan, V., Thibault, C., Capilla, F., Al Saati, T., Gennero, I., Jurdic, P., Jolicoeur, P., Daviginon, J.-L., Mempel, T. Benichou, S., Maridonneau-Parini, I. and Verollet, C. (2018) The bone degradation machinery of osteoclasts : a novel HIV-1 target that contributes to bone loss. Proc. Natl. Acad. Sci. USA, 115:E2556-E2565.

    Bracq, L., Xie, M., Benichou, S., and Bouchet, J. (2018) Mechanisms for cell-to-cell transmission of HIV-1. Front. Immunol., 9:260

    Durand A, Audemard-Verger A, Guichard V, Mattiuz R, Delpoux A, Hamon P, Bonilla N, Rivière M, Delon J, Martin B, Auffray C, Boissonnas A, Lucas B. (2018) Profiling the lymphoid-resident T cell pool reveals modulation by age and microbiota. Nat Commun. 9(1):68.

    Bracq, L., Xie, M., Lambelé, M., Vu, L.-T., Matz, J., Schmitt, A., Delon, J., Zhou, P., Randriamampita, C., Bouchet, J., and Benichou, S. (2017). T cell-macrophage fusion triggers multinucleated giant cell formation for HIV-1 spreading. J. Virol., 91, e01237-17.

    Aguera Gonzalez S, Burton O, Vazquez Chavez E, Cuche C, Herit F, Bouchet J, Lasserre R, del Rio-Iñiguez I, Di Bartolo V, Alcover A. (2017) Adenomatous polyposis coli and microtubules ensure NFAT localization, controlling Treg production of anti-inflammatory cytokines. Cell Reports, Oct 3.  doi: 10.1016/j.celrep.2017.09.020.

    Bouchet J, Del Río-Iñiguez I, Lasserre R, Agüera-Gonzalez S, Cuche C, Vázquez-Chávez E, McCaffrey MW, Di Bartolo V, Alcover ACorr. Rab11-FIP3 regulation of Lck endosomal traffic controls T cell receptor signal transduction. J Immunol. 2017 Apr 1. doi: 10.4049/jimmunol.1600671.

    Bouchet J*, del Río-Iñiguez I*, Alcover A. Imaging vesicular traffic at the immune synapse. Methods in Molecular Biology "The immune synapse" 2017. doi: 10.1007/978-1-4939-6881-7_9.

    Del Río-Iñiguez I*, Bouchet J*, Alcover A. Studying the immune synapse in HIV-1 infection. Methods in Molecular Biology "The immune synapse" 2017. doi: 10.1007/978-1-4939-6881-7_34.

    Groussaud D, Khair M, Tollenaere AI, Waast L, Kuo MS, Mangeney M, Martella C, Fardini Y, Coste S, Souidi M, Benit L, Pique C, Issad T. Hijacking of the O-GlcNAcZYME complex by the HTLV-1 Tax oncoprotein facilitates viral transcription. PLoS Pathog. 13(7):e1006518 (2017).

    Liu, L., Wang, W., Matz, J., Ye, C., Bracq, L., Delon, J., Kimata, J., Chen, Z., Benichou, S.* and Zhou, P.* (2016) Glycosyl Phosphatidylinositol-Anchored Variable Region of Llama Heavy Chain Only Antibody JM4 Efficiently Blocks Both Cell-Free and T Cell-T Cell Transmission of Human Immunodeficiency Virus Type 1. J. Virol., 90, 10642-10659. (*equal contribution)

    Herate, C., Vigne, C., Guenzel, C.A., Lambele, M., Rouyez, M.C., and Benichou S. (2016) Uracil DNA glycosylase interacts with the p32 subunit of the replication protein A complex to modulate HIV-1 reverse transcription for optimal virus dissemination. Retrovirology, 13, e26.

    Bouchet J, Del Río-Iñiguez I, Lasserre R, Agüera-Gonzalez S, Cuche C, Danckaert A, McCaffrey MW, Di Bartolo V, Alcover A. Rac1-Rab11-FIP3 regulatory hub coordinates vesicle traffic with actin remodeling and T-cell activation. EMBO J. 2016 Jun 1. doi: 10.15252/embj.201593274.

    Herate, C., Ramdani, G., Grant, N.J., Marion, S., Gasman, S., Niedergang, F., Benichou, S.*, and Bouchet J.* (2016) Phospholipid scramblase 1 modulates FcR-mediated phagocytosis in differentiated macrophages. PLoS One, 11(1): e0145617. (*equal contribution)

    Saitakis, M., Dogniaux, S., Goudot, C., Bufi, N., Asnacios, S., Maurin, M., Randriamampita, C., Asnacios, A., & Hivroz, C. Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity. eLife (2016) J8;6

    Guedj, C., Abraham, N. & Randriamampita, C. (2016) L'antisynapse : présynapse et garde-fou de l'activation lymphocytaire? Médecine/Sciences 12:1053-1056

    Froehlich J, Versapuech M, Megrelis L, Largeteau Q, Meunier S, Tanchot C, Bismuth G, Delon J, Mangeney M (2016). FAM65B controls the proliferation of transformed and primary T cells. Oncotarget. 7: 63215-63225.

    Guedj C, Abraham N, Jullié D, Randriamampita C. (2016) T cell adhesion triggers an early signaling pole distal to the immune synapse. J Cell Sci. 129: 2526-2537

    Dumas, A., Lê-Bury, G., Marie-Anaïs, F., Herit, F., Mazzolini, J., Guilbert, T., Bourdoncle, P., Russell, D.G., Benichou, S., Zahraoui, A., and Niedergang F. 2015 The HIV-1 protein Vpr impairs phagosome maturation by controlling microtubule-dependent trafficking. J. Cell Biol., 211, 359-372.

    Verollet, C., Souriant, S., Bonnaud, E., Jolicoeur, P., Raynaud-Messina, B., Benichou, S., Fackler, O.T, Poincloux, R. and Maridonneau-Parini, I. (2015) HIV-1 reprograms the migration of macrophages. Blood, 125, 1611-1622.

    Hérate, C., Lambelé, M. and Benichou, S. (2015) The essential role of HIV "auxiliary" proteins. In : Hope T., Stevenson M., Richman D. (eds) Encyclopedia of AIDS. Springer, New York, NY.

    Agüera-Gonzalez S*, Bouchet J*, Alcover A. Immunological Synapse. Encyclopedia of Life Science. eLS. John Wiley & Sons Ltd, Chichester. 2015 Jun. doi: 10.1002/9780470015902.a0004027.pub2

    Dragin L, Munir-Matloob S, Froehlich J, Morel M, Sourisce A, Lahouassa H, Bailly K, Mangeney M, Ramirez BC, Margottin-Goguet F.Evidence that HIV-1 restriction factor SAMHD1 facilitates differentiation of myeloid THP-1 cells. Virol J. 2015 Nov 25;12:201.

    Guenin-Macé L, Baron L, Chany AC, Tresse C, Saint-Auret S, Jönsson F, Le Chevalier F, Bruhns P, Bismuth G, Hidalgo-Lucas S, Bisson JF, Blanchard N, Demangel C.. Shaping mycolactone for therapeutic use against inflammatory disorders. Sci Transl Med. 2015;7(289):289ra85. doi:10.1126/scitranslmed.aab0458.

    Nogueira E, Lager F, Le Roux D, Nogueira P, Freitas J, Charvet C, Renault G, Loureiro A, Almeida CR, Ohradanova-Repic A, Machacek C, Bernardes GJ, Moreira A, Stockinger H, Burnet M, Carmo AM, Gomes AC, Preto A, Bismuth G, Cavaco-Paulo A.. Enhancing Methotrexate Tolerance with Folate Tagged Liposomes in Arthritic Mice. J Biomed Nanotechnol. 2015;11(12):2243-2252.

    Lombes A, Durand A, Charvet C, Rivière M, Bonilla N, Auffray C, Lucas B, Martin B. Adaptive Immune-like γ/δ T Lymphocytes Share Many Common Features with Their α/β T Cell Counterparts. J Immunol. 2015 195:1449-58.

    Toubiana J, Rossi AL, Belaidouni N, Grimaldi D, Pene F, Chafey P, Comba B, Camoin L, Bismuth G, Claessens YE, Mira JP, Chiche JD.. Src-family-tyrosine kinase Lyn is critical for TLR2-mediated NF-kappaB activation through the PI 3-kinase signaling pathway. Innate Immun. 2015;21(7):685-697. doi:10.1177/1753425915586075.

    Lainé, A., Martin, B., Luka, M., Mir, L., Auffray, C., Lucas, B., Bismuth, G., and Charvet, C. (2015). Foxo1 Is a T Cell-Intrinsic Inhibitor of the RORγt-Th17 Program. J. Immunol.195:1791-803

    Clement M, Fornasa G, Loyau S, Morvan M, Andreata F, Guedj K, Khallou-Laschet J, Larghi P, Le Roux D, Bismuth G, Chiocchia G, Hivroz C, Newman DK, Nicoletti A, Caligiuri G.. Upholding the T cell immune-regulatory function of CD31 inhibits the formation of T/B immunological synapses in vitro and attenuates the development of experimental autoimmune arthritis in vivo. J Autoimmun. 2015;56:23-33. doi:10.1016/j.jaut.2014.09.002.

    Machado-Neto, J.A., Lazarini, M., Favaro, P., Nowill, A.E., Costa, F.F., Benichou, S., Olalla Saad, S.T., and Traina, F. (2014) ANKHD1 silencing inhibits Stathmin 1 activity, cell proliferation and migration of leukemia cells. BBA Mol. Cell R., 1853, 583-593.

    Lülf, S., Matz, J., Rouyez, M.C., Järviluoma, A., Saksela, K., Benichou, S. and M. Geyer. (2014) Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody. Retrovirology, 11, e24.

    Guenzel, C., Hérate, C. and S. Benichou. (2014) HIV-1 Vpr: a still "enigmatic multitasker". Frontiers Microbiology, 5, 1-13.

    Matz, M., Hérate, C., Bouchet, J., Dusetti, N., Gayet, O., Baty, D., Benichou, S., and P. Chames. (2014) Selection of intracellular single-domain antibodies targeting the HIV-1 Vpr protein by cytoplasmic Yeast Two-hybrid system. PLoS One, 9 (12): e113729.

    Ghossoub R, Lembo F, Rubio A, Gaillard CB, Bouchet J, Vitale N, Slavík J, Machala M, Zimmermann P. Syntenin-ALIX exosome biogenesis and budding into multivesicular bodies are controlled by ARF6 and PLD2. Nat Commun. 2014 Mar 18;5:3477. doi: 10.1038/ncomms4477.

    Bouchet J. Alcover A. La synapse immunologique, une plate-forme de signalisation dynamique pour l’activation des lymphocytes T Med Sci (Paris). 2014 Jun-Jul;30(6-7):665-70. doi: 10.1051/medsci/20143006017.

    Chandra, V., Albagli-Curiel, O., Hastoy, B., Piccand, J., Randriamampita, C., Vaillant, E., Cavé, H., Busiah, K., Froguel, P., Vaxillaire, M., Rorsman, P., Polak, M. and Scharfmann, R.. (2014) RFX6 Regulates Insulin Secretion by Modulating Ca2+ Homeostasis in Human β Cells. Cell Reports 9: 2206-2218

    Delpoux A, Yakonowsky P, Durand A, Charvet C, Valente M, Pommier A, Bonilla N, Martin B, Auffray C, Lucas B. TCR signaling events are required for maintaining CD4 regulatory T cell numbers and suppressive capacities in the periphery. J Immunol. 2014 193:5914-23

    Mokrani M, Klibi J, Bluteau D, Bismuth G, Mami-Chouaib F. Smad and NFAT pathways cooperate to induce CD103 expression in human CD8 T lymphocytes. J Immunol. 2014;192(5):2471-2479. doi:10.4049/jimmunol.1302192.

    Megrelis L. and Delon J. Rapid and robust analysis of cellular and molecular polarization induced by chemokine signaling. J Vis Exp (94) (2014)

    Jin J, Colin P, Staropoli I, Lima-Fernandes E, Ferret C, Demir A, Rogée S, Hartley O, Randriamampita C, Scott MG, Marullo S, Sauvonnet N, Arenzana-Seisdedos F, Lagane B, Brelot A (2014). Targeting Spare CC Chemokine Receptor 5 (CCR5) as a Principle to Inhibit HIV-1 Entry. J Biol Chem. 2014; 289(27):19042-19052

    Randriamampita, C. and Lellouch A. C (2014). Imaging early signaling events in T lymphocytes with fluorescent biosensors Biotechnology Journal 2014; 9: 203-12

    Schlecht-Louf G, Mangeney M, El-Garch H, Lacombe V, Poulet H, Heidmann T.A targeted mutation within the feline leukemia virus (FeLV) envelope protein immunosuppressive domain to improve a canarypox virus-vectored FeLV vaccine. J Virol. 2014 Jan;88(2):992-1001.

    Bregnard, C., Zamborlini, A., Leduc, M., Chafey, P., Camoin, L., Saïb, A., Benichou, S., Danos, O. and S. Basmaciogullari (2013) Comparative proteomic analysis of HIV-1 particles reveals a role for ezrin and EHD4 in the Nef-dependent increase of virus infectivity. J. Virol., 87, 3729-3740.

    Matz, J., Kessler, P., Bouchet, J., Combes, O., Baty, D., Barin, F., Martin, L., Chames*, P. and S. Benichou* (2013) Straightforward selection of broadly neutralizing single-domain antibodies targeting the conserved CD4 and co-receptor binding sites of HIV-1 gp120. J. Virol., 87, 1137-1149. (*equal contribution)

    Tabbekh M, Mokrani-Hammani M, Bismuth G, Mami-Chouaib F. T-cell modulatory properties of CD5 and its role in antitumor immune responses. Oncoimmunology. 2013;2(1):e22841. doi:10.4161/onci.22841.

    Martin B, Auffray C, Delpoux A, Pommier A, Durand A, Charvet C, Yakonowsky P, de Boysson H, Bonilla N, Audemard A, Sparwasser T, Salomon BL, Malissen B, Lucas B. Highly self-reactive naive CD4 T cells are prone to differentiate into regulatory T cells. Nat Commun. 2013;4:2209.

    Rougerie,P., Largeteau, Q., Megrelis,L., Carrette, F., Lejeune,T., Toffali, L., Rossi, B., Zeghouf, M., Cherfils, J., Constantin, G., Laudanna, C., Bismuth, G., Mangeney, M., Delon, J. Fam65b is a new transcriptional target of FOXO1 that regulates RhoA signaling for T lymphocyte migration. 2013; J Immunol 190(2):748-755.

    Bouchet, J., Hérate, C., Guenzel, C. Vérollet, C. Järviluoma, A., Mazzolini, J., Rafie, S., Chames, P., Saksela, K., Niedergang, F., Maridonneau-Parini, I. and S. Benichou. (2012) Single-domain antibody-SH3 fusions for efficient neutralization of HIV-1 Nef functions. J. Virol., 86, 4856-4867.

    Guenzel, C. A., Hérate, C., Le Rouzic, E., Maidou-Peindara, P., Sadler, H.A., Rouyez, M.-C., Mansky, L.M. and S. Benichou. (2012) Recruitment of the nuclear form of uracil DNA glycosylase into virus particles participates in the full infectivity of HIV-1. J. Virol., 86, 2533-2544.

    Fourati, S., Malet, I., Guenzel, C., Soulie, C., Maidou-Peindara, P., Morand-Joubert, L., Peytavin, G., Simon, A., Katlama, C., Benichou, S., Calvez, V., and A.G. Marcelin. (2011) DE17A mutation in HIV-1 Vpr confers resistance to didanosine in association with Thymidine analogue mutations. Antiviral Res., 93,167-174.

    Järviluoma, A., Strandin, T., Lülf, S., Bouchet, J., Mäkelä, A.R., Geyer, M., Benichou, S., and K. Saksela. (2012) High-affinity target binding engineered via fusion of a single-domain antibody fragment with a ligand-tailored SH3 domain. PLoS ONE, 7(7): e40331.

    Hauck, F., Randriamampita, C., Martin, E., Gerart, S., Lambert, N., Lim, A., Soulier, J., Maciorowski, Z., Touzot, F., Moshous, D., Quartier-dit-Maire, P., Heritier, S., Blanche, S., Fraitag, S., Brousse, N., Veillette, A., Hivroz, C., Fischer, A., Latour, S. and Picard, C. Primary T-Cell Immunodeficiency with Immunodysregulation Caused by Autosomal Recessive LCK Deficiency. J Allergy Clin Immunol 2012;  130(5):1144-1152.e11.

    Le Roux, D., Le Bon, A., Dumas, A., Taleb, K., Sachse, M., Sikora, R., Julithe, M., Benmerah, A., Bismuth, G., Niedergang, F. Antigen stored in dendritic cells after macropinocytosis is released unprocessed from late endosomes to target B cells Blood 2012; 119(1):95-105

    Oliveira, M. I., Goncalves, C. M., Pinto, M., Fabre, S., Santos, A. M., Lee, S. F., Castro, M. A., Nunes, R. J., Barbosa, R. R., Parnes, J. R., Yu, C., Davis, S. J., Moreira, A., Bismuth, G., Carmo, A. M. CD6 attenuates early and late signaling events, setting thresholds for T-cell activation Eur J Immunol 2012; 42(1):195-205

    Rougerie, P. and Delon, J. Rho GTPases: masters of T lymphocytes migration and activation Immunol Lett 2012; 142: 1-13.

    Delpoux, A., Poitrasson-Rivière, M., Le Campion, A., Pommier, A., Yakonowsky, P. Jacques, S., Letourneur, F., Randriamampita, C., Lucas, B. and Auffray, C. Foxp3-independent loss of regulatory CD4 T cell suppressive capacities induced by self-deprivation European Journal of Immunology 2012; 42(5):1237-49

    Nzounza, P., Chazal, M., Guedj, C., Schmitt, A., Masse, J. M., Randriamampita, C., Pique, C., Ramirez, B.C. The Scaffolding Protein Dlg1 Is a Negative Regulator of Cell-Free Virus Infectivity but Not of Cell-to-Cell HIV-1 Transmission in T Cells PLoS One 2012; 7(1):e30130


    Equipes du département