Institut de recherche biomédicale
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    Publications depuis 2009


    Ambre Petitalot, Elodie Dardillac, Eric Jacquet, Naima Nhiri, Josée Guirouilh-Barbat, Patrick Julien, Isslam Bouazzaoui, Dorine Bonte, Jean Feunteun, Jeff Schnell, Philippe Lafitte, Jean-Christophe Aude, Catherine Nogues, Etienne Rouleau, Rosette Lidereau, Bernard Lopez, Sophie Zinn-Justin, and Sandrine Caputo. Combining Homologous Recombination and Phosphopeptide-binding Data to Predict the Impact of BRCA1 BRCT Variants on Cancer Risk. (2018). Mol Cancer Res. DOI: 10.1158/1541-7786.MCR-17-0357.

    Olivier Piétrement, Fidel Antonio Castro-Smirnov, Eric Le Cam and Bernard S. LopezSepiolite as a new nanocarrier for DNA transfer into mammalian cells: proof of concept, issues and perspectives. (2018) Chemicalrecords. 18, 849–857. DOI: 10.1002/tcr.201700078

    Flavie Coquel, Maria-Joao Silva, Hervé Técher, Karina Zadorozhny, Sushma Sharma, Jadwiga Nieminuszczy, Clément Mettling, Elodie Dardillac, Antoine Barthe, Anne-Lyne Maurin, Alexy Promonet, Alexandra Cribier, Amélie Sarrazin, Wojciech Niedzwiedz, Bernard Lopez, Vincenzo Costanzo, Lumir Krejci, Andrei Chabes, Monsef Benkirane, Yea-Lih Lin and Philippe Pasero. SAMHD1 acts at stalled replication forks to prevent ssDNA-mediated induction of type I interferons (2018). Nature, 557, 57-61. doi: 10.1038/s41586-018-0050-1

    Charpentier M, Khedher, Menoret S, Brion A, Lamribet K, Dardillac E, Boix C, Perrouault L, Tesson L, Gény S, Decian A, Itier JM, Anegon I, Lopez B, Giovannangeli C and Concordet JP. CtIP fusion to Cas9 enhances transgene integration by homology-dependent repair. (2018) Nature Comm, 19;9(1):1133. doi: 10.1038/s41467-018-03475-7.

    Francois Lallemand , Ambre Petitalot , Sophie Vacher , Leanne De Koning , Karim Taouis, Bernard S. Lopez, Sophie Zinn-Justin , Nicole Dalla Venezia , Walid Chemlali , Anne Schnitzler , Rosette Lidereau , Ivan Bieche and Sandrine M. Caputo. Involvement of the FOXO6 transcriptional factor in breast carcinogenesis (2018). Oncotarget, 9(7):7464-7475. doi: 10.18632/oncotarget.23779. eCollection 2018 Jan 26.

    Camille Gelot, Josée Guirouilh-Barbat and Bernard S. Lopez (2018). The Cohesion complex maintains genome stability by preventing the end-joining of distant DNA ends in the S phase. Mol Cell Oncol, 5:3, e1154123, DOI: 10.1080/23723556.2016.1154123

    Alexis Fouquin, Josée Guirouilh-Barbat, Bernard Lopez, Janet Hall, Mounira Amor-Gueret and Vincent Pennaneach (2017). PARP2 controls DSB repair pathway choice by limiting 53BP1 accumulation at DNA damage sites and promoting end-resection. Nucleic Acids Res., doi: 10.1093/nar/gkx881

    Christian Bressy, Dragomira Majhen, Najat Raddi, Wael Jdey, Gaétan Cornilleau, Léna Zig, Josée Guirouilh Barbat, Bernard Lopez, Olivia Bawa, Paule Opolon, Elodie Grellier and Karim Benihoud (2017). Combined therapy of colon carcinomas with an oncolytic adenovirus and valproic acid. Oncotarget. 8, pp: 97344-97360

    Fidel Antonio Castro-Smirnov, Jeanne Ayache, Jean-Rémi Bertrand, Elodie Dardillac, Eric Le Cam, Olivier Piétrement, Pilar Aranda, Eduardo Ruiz-Hitzky and Bernard S. Lopez(2017). Cellular uptake pathways of sepiolite nanofibers and DNA transfection improvement. Sci Reports, 7: 5586. doi: 10.1038/s41598-017-05839-3.

    Ayeong So, Tangui Le Guen, Bernard S. Lopez* and Josée Guirouilh-Barbat* (*Co-corresponding authors) (2017). Genomic rearrangements induced by unscheduled DNA double strand breaks in somatic mammalian cells. FEBS J. doi: 10.1111/febs.14053.

    Camille Gelot, Josée Guirouilh-Barbat, Tangui Le Guen, Elodie Dardillac, Catherine Chailleux, Yvan Canitrot and Bernard S. Lopez (2016). The cohesin complex prevents the end-joining of distant DNA double-strand ends. Mol Cell, 61, 15-26.

    Josée Guirouilh-Barbat, Camille Gelot, Anyong Xie, Elodie Dardillac, Ralph Scully and Bernard S. Lopez (2016) 53BP1 Protects Against CtIP-dependent Capture of Ectopic Chromosomal Sequences at the Junction of Distant Double-Strand Breaks. PLoS Genet. DOI:10.1371/journal.pgen.1006230.

    Therese Wilhelm, Sandrine Ragu, Indiana Magdalou, Christelle Machon, Elodie Dardillac, Hervé Técher, Jérôme Guitton, Michelle Debatisse and Bernard S. Lopez (2016). Slow Replication Fork Velocity of Homologous Recombination-Defective Cells Results from Endogenous Oxidative Stress. PLoS Genet., 12(5): e1006007. doi:10.1371/journal.pgen.1006007

    Fidel Antonio Castro-Smirnov, Olivier Piétrement, Pilar Aranda, Jean-Rémi Bertrand, Jeanne Ayache, Eric Le Cam, Eduardo Ruiz-Hitzky and Bernard S. Lopez (2016). Physical interactions between DNA and sepiolite nanofibers, and potential application for DNA transfer into mammalian cells. Sci Reports, doi:10.1038/srep36341.

    Yannick Saintigny, François Chevalier, Anne Bravard, Elodie Dardillac, David Laurent, Sonia Hem, Jordane Dépagne, Juan Pablo Radicella and Bernard S. Lopez (2016). A threshold of endogenous stress is required to engage cellular response to protect against mutagenesis”. Sci Reports, 6:29412 | DOI: 10.1038/srep29412

    Pierre Thouvenot, Lou Fourriere, Elodie Dardillac, Barbara Ben Yamin, Aurianne Lescure, Vincent Lejour, Xavier Heiligenstein, Jean-Baptiste Boule, Maryse Romao, Graca Raposo-Benedetti, Bernard S. Lopez, Alain Nicolas, and Gael A Millot. (2016). Yeast cells reveal the misfolding and the cellular mislocalisation of the human BRCA1 protein. J. Cell Sci. doi: 10.1242/jcs.192880.

    Camille Gelot, Josée Guirouilh-Barbat and Bernard S. Lopez (2016). The cohesin complex prevents the end-joining of distant DNA double-strand ends in S phase: consequences on genome stability maintenance. Nucleus, DOI:10.1080/19491034.2016.1194159.

    Shu Zhang, Corinne Pondarre, Gaelle Pennarum, Helene labussiere-wallet, Gabriela Vera, Marie Chansel, Benoit France, Isabelle Rouvet, Patrick Revy, Bernard Lopez, Jean Soulier, Pascale Bertrand, Isabelle Callebaut, and Jean-Pierre de Villartay (2016). A nonsense mutation in the DNA repair factor Hebo, encoded by the ERCC6L2 gene, causes mild bone marrow failure and microcephaly. J Exp Med., doi/10.1084/jem.20151183.

    Hervé Técher, Stéphane Koundrioukoff, Sandra Carignon, Therese Wilhelm, Gaël A. Millot, Bernard S. Lopez, Olivier Brison and Michelle Debatisse (2016). Signaling from Mus81/Eme2-dependent damage elicited by Chk1 deficiency modulates replication fork speed and origin usage. Cell Reports, doi: 10.1016/j.celrep.2015.12.093.

    Gemael-Cedrick Taty-Taty, Catherine Chailleux, Muriel Quaranta, Ayeong So, Josee Guirouilh-Barbat, Bernard Lopez, Pascale Bertrand, Didier Trouche and Yvan Canitrot (2016). Control of alternative end joining by the chromatin remodeler p400 ATPase. Nucleic acids research,  44, 1657–1668.

    Camille Gelot,Indiana Magdalou and Bernard S. Lopez  (2015). Replication stress in Mammalian cells and Its consequences for Mitosis. Genes  6(2), 267-298; doi:10.3390

    Tangui Le Guen, Sandrine Ragu, Josée Guirouilh-Barbat and Bernard S. Lopez (2015). Role of the double-strand break repair pathway in the maintenance of genomic stability. Mol Cell Oncol. 2:1, e968020, DOI:10.4161/23723548.2014.968020

    Olivia Barton, Steffen C. Naumann, Ronja Diemer-Biehs, Julia Künzel, Monika Steinlage, Sandro Conrad, Nodar Makharashvili, Jiadong Wang, Lin Feng, Bernard S. Lopez, Tanya T. Paull, Junjie Chen, Penny A. Jeggo and Markus Löbrich (2014). Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1. J. Cell Biol. 206, 877-894.

    Kenza Mamouni, Agnese Cristini, Josée Guirouilh-Barbat, Sylvie Monferran, Anthony Lemarié, Jean-Charles Faye, Bernard Lopez, Gilles Favre, and Olivier Sordet (2014). RhoB promotes γH2AX dephosphorylation and DNA double-strand break repair. Mol. Cell Biol. 34, 3144-3145.

    Josée Guirouilh-Barbat, Sarah Lambert, Pascale Bertrand and Bernard S. Lopez   (2014). Is homologous recombination really an error-free process? Frontiers in Genetics, doi: 10.3389/fgene.2014.00175. eCollection 2014.

    Indiana Magdalou, Bernard S Lopez, Philippe Pasero and Sarah AE Lambert. (2014) The causes of replication stress and their consequences on genome stability and cell fate. Seminars Cell and Dev. Biol. 30, 154-164.

    Carole Beck, Christian Boehler, Josée Guirouilh Barbat, Marie-Elise Bonnet, Giuditta Illuzzi, Philippe Ronde, Laurent R. Gauthier,NajatMagroun, Anbazhagan Rajendran, Bernard S Lopez, Ralph Scully, François D. Boussin, Valérie Schreiber, Françoise Dantzer (2014). PARP3 affects the relative contribution of homologous recombination and non homologous end joining pathways. Nucleic Acids Res. 42, 5616-5632.

    Therese Wilhelm, Indiana Magdalou, Aurélia Barascu, Hervé Técher, Michelle Debatisse and Bernard S. Lopez (2014). Spontaneous slow replication fork progression elicits mitosis alterations in homologous recombination-deficient mammalian cells. Proc Natl. Acad. Sci. USA. 111.763-768.

    Mireille Bétermier, Pascale Bertrand and Bernard S. Lopez (2014). Is non-homologous end-joining really an inherently error-prone process? PLoS Genet., 10, e1004086

    Anastazja Grabarz, Josée Guirouilh-Barbat,Aurelia Barascu, Gaëlle Pennarun, Diane Genet, Emilie Rass, Susanne M. Germann, Pascale Bertrand, Ian D. Hickson and Bernard S. Lopez (2013). A role for BLM in double strand break repair pathway choice: prevention of CtIP/Mre11-mediated alternative non-homologous end-joining. Cell Reports, 5, 21-28. DOI: 10.1016/j.celrep.2013.08.034.

    Agathe Bacquin, Caroline Pouvelle, Nicolas Siaud, Mylene Perderiset, Sophie Salome-Desnoulez, Carine Tellier-Lebegue, Bernard Lopez, Jean-Baptiste Charbonnier, and Patricia Kannouche (2013). The helicase FBH1 is tightly regulated by PCNA via CRL4(Cdt2) proteolysis in human cells. Nucleic Acids Res., 41, 6501-6513.

    Jiang G, Plo I, Wang T,  Rahman M, Cho JH, Yang E, Lopez BS and Xia F. (2013). BRCA1-Ku80 interaction enhances end-joining fidelity of chromosomal double-strand breaks in G1 phase of the cell cycle. J. Biol. Chem.,  258, 8966-8976.

    Aurelia Barascu, Catherine Le Chalony, Gaëlle Pennarun, Diane Genet, Naima Imam, Bernard S. Lopez* and Pascale Bertrand* (*Co-corresponding authors) (2012). Oxydative stress induces ATM-independent senescence pathway through p38 MAPK-mediated lamin B1 accumulation, in response to oxidative stress. EMBO J., 31, 1080-1094. (commented in the same issue).

    ImenneBoubakour-Azzouz, Pascale Bertrand, Aurélie Claes, Bernard S. Lopez*, François Rougeon*. (*Co-corresponding authors) (2012). Terminal deoxynucleotidyl transferase requires KU80 and XRCC4 to promote N-addition at non-V(D)J chromosomal breaks in non-lymphoid cells.. Nucleic Acids Res.,  40, 8381-8391.

    Corentin Laulier, and Bernard S. Lopez (2012). The secret life of Bcl-2: Apoptosis-independent inhibition of DNA repair by Bcl-2 family members. Mutat Res Review in Mutation  Res. 751, 247-257.

    Anastazja Grabarz, Aurélia Barascu, Josée Guirouilh-Barbat and Bernard S. Lopez. Initiation of DNA double strand break repair: signaling and single-stranded resection dictates the choice between homologous recombination, non-homologous end-joining and alternative end-joining. Am J. Cancer Res., 2, 249-268.

    Charlene Lemaitre, Benoit Fisher, Alkmini Kalousi, Josee Guirouilh-Barbat, Or Shahar, Anne-Sophie Hoffbeck, Michal Goldberg, Pascale Betrand, Bernard Lopez, Laurent Brino and Evi Soutoglou (2012). The nucleoporin 153, a novel player in double strand break repair and DNA damage response. Oncogene, , 31, 4803-4809.

    Corentin Laulier, Aurélia Barascu, Josée Guirouilh-Barbat, Gaëlle Pennarun, Catherine Le Chalony, François Chevalier, Gaëlle Palierne, Pascale Bertrand, Jean Marc Verbavatz and  Bernard S. Lopez (2011) Bcl-2 inhibits nuclear homologous recombination by localizing BRCA1 to the endomembranes. Cancer Res. 71, 3590-3602.

    Amandine Garcia, Monique Buisson, Pascale Bertrand, Ruth Rimokh, Etienne 
Bernard S. Lopez, Rosette Lidereau, Ivan Mikaélian, Sylvie Mazoyer (2011) Down-regulation of BRCA1 expression by 
miR-146a and miR-146b-5p in triple
negative sporadic breast cancer. EMBO Molecular Medicine, 3, 279-290

    Josée Guirouilh-Barbat, Therese Wilhelm and Bernard S. Lopez (2010) AKT1/BRCA1 in the control of homologous recombination and genetic stability: the missing link between hereditary and sporadic breast cancers. Oncotarget, 1, 691-699.

    Emilie Rass, Anastazja Grabarz, Isabelle Plo, Jean Gautier, Pascale Bertrand and Bernard S. Lopez(2009) Role of MRE11 in chromosomal non-homologous end-joining in mammalian cells. Nat. Struct. Mol. Biol., 16, 819-824. (article commenté dans un News & Views du même numéro).

    Isabelle Plo and Bernard Lopez (2009) AKT1 represses gene conversion induced by different genotoxic stresses and induces supernumerary centrosomes and aneuploidy, in hamster ovary cells. Oncogene, 28, 2231-2237.


    Revues en Français.

    Emilie Rass, Anastazja Grabarz, Pascale Bertrand et Bernard S. Lopez (2012) Réparation des cassures doubles brin de l’ADN, un mécanisme peut en cacher un autre: le NHEJ alternatif. Cancer et Radiothérapie, 16, 1-10.

    Publications dans des ouvrages (chapitres de livres)

    Camille Gelot, Tangui Le-Guen, Sandrine Ragu and Bernard S. Lopez (2016) Double-Strand Break Repair: Homologous Recombination In Mammalian Cells. Genome Stability. Ed. Igor and Olga Kovalshuk. Elsevier Publication.

    Aurélia Barascu, Anastazja Grabarz and Bernard S. Lopez (2011) Homologous recombination in mammals. « Site directed insertion of transgenes » Ed. Springer. 

    Pascale Bertrand, Jérome Lebeau, Catherine Lecomte-Pradines, Odile Rigaud & Bernard Lopez (2009). Chapitre 14: Réponses au niveau cellulaire et conséquences.Ouvrage Toxicologie nucléaire environnementale et humaine, Ed. Lavoisier. (B. Lopez coordinateur du chapitre)