Institut de recherche biomédicale
     

    Thèmes de recherche et publications

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    Les thèmes de recherche développés dans l’équipe peuvent se répartir selon 3 grands axes :

     

    1) Rôle des facteurs solubles dans la migration neuronale : la nétrine-1 et ses partenaires
     

     

     

     PUBLICATIONS :

    - Backer*, S., Lokmane*, L., Landragin, C., Deck, M., Garel, S., Bloch-Gallego, E. (2018) Trio GEF mediates RhoA activation downstream of Slit2 and coordinates telencephalic wiring. Development sous presse

    - Couesnon, A., Offner, N., Bernard, V., Chaverot, N., Backer, S., Dimitrov, A., Perez, F., Molgo, J. and Bloch-Gallego, E. (2013) CLIPR-59, a protein essential for neuro-muscular juncion stability during mouse late embryonic development. Development, 140(7):1583-93.

    - Hidalgo-Sánchez M, Backer S, Puelles L, Bloch-Gallego E. (2012) Origin and plasticity of the subdivisions of the inferior olivary complex. Dev Biol. 371(2):215-26.

    - Zylbersztejn K, Petkovic M, Burgo A, Deck M, Garel S, Marcos S, Bloch-Gallego E, Nothias F, Serini G, Bagnard D, Binz T, Galli T. (2012) The vesicular SNARE Synaptobrevin is required for Semaphorin 3A axonal repulsion. J Cell Biol. 196(1):37-46.

    - Marcos, S., Backer, S., Causeret, F., Tessier-Lavigne, M. and Bloch-Gallego, E. (2009) Differential roles of Netrin-1 and its receptor DCC in inferior olivary neuron migration. Mol. Cell. Neurosci. 41 (4): 429-439.

    - Marcos, S., Moreau, J., Backer, S., Job, D., Andrieux, A. and Bloch-Gallego, E. (2009) Tubulin tyrosination is required for the proper organization and pathfinding of the growth cone. PLoS One 4 (4):e5405.

    - Backer, S., Hidalgo-Sánchez, M., Offner, N., Portales-Casamar, E., Debant, A., Fort, P., Gauthier-Rouviere, C. and Bloch-Gallego, E. (2007) Role of Trio in the mature organization of neuronal clusters in the hindbrain. J. Neurosci. 27(39):10323–10332

    - Bloch-Gallego, E., Causeret, F., Ezan, F., Backer, S., Hidalgo-Sanchez, M. (2005)
    Development of precerebellar nuclei: instructive factors and intracellular mediators in neuronal migration, survival and axon pathfinding. Brain Research Review, 49(2):253-66

    - Meriane, M., Tcherkezian, J., Webber, C.A., Danek, E.I., Triki, I., McFarlane, S., Bloch-Gallego, E. and Lamarche-Vane, N. (2004) Phosphorylation of DCC by Fyn mediates Netrin-1 signaling in growth cone guidance J Cell Biol., 167 : 687-98.

    - Causeret, F*, Hidalgo-Sanchez*, M., Fort, P., Backer, S., Popoff, M.R., Gauthier-Rouvière, C. and Bloch-Gallego E. (2004)
    Distinct roles of Rac1/Cdc42 and Rho/ROCK for axon outgrowth and nucleokinesis of precerebellar neurons toward netrin-1.Development, 131 : 2841-2852

    - Causeret F., Danne F., Ezan F., Sotelo C. and Bloch-Gallego E. (2002)
     Slit antagonizes netrin-1 attractive effects during the migration of inferior olivary neurons. Dev. Biol., 246: 420-440.

    - Backer, S., Sakurai, T., Grumet, M., Sotelo, C. and Bloch-Gallego E. (2002)
    Nr-CAM and TAG-1 are expressed in distinct populations of developing precerebellar and cerebellar neurons. Neuroscience, 113: 743-748.

    - Spassky, N., de Castro, F., Le Bras, B., Heydon, K., Gueraud-le Saux, F., Bloch-Gallego, E., Chédotal, A., Zalc, B., Thomas, J.L. (2002) Directional guidance of oligodendroglial migration by class 3 semaphorins and netrin-1. J. Neurosci., 22: 5992-6004.

    - Llambi F, Causeret F, Bloch-Gallego E* and Mehlen P*. (2001) Netrin-1 acts as a survival factor via its receptors UNC5H and DCC. EMBO J., 20 (11):2715-22 (* co-authors).

    - Bloch-Gallego, E, Ezan, F., Tessier-Lavigne, M. and Sotelo, C. (1999) Floor-plate and netrin-1 are involved in the migration and survival of inferior olivary neurons. J. Neurosci., 19: 4407-4420.

     

     

     

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