Institut de recherche biomédicale
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     Metabolomic differences in blastocoel and uterine fluids collected in vivo by ultrasound biomicroscopy on rabbit embryos. Calderari S, Daniel N, Mourier E, Richard C, Dahirel M, Lager F, Marchiol C, Renault G, Gatien J, Nadal-Desbarats L, Chavatte-Palmer P, Duranthon V. Biol Reprod. 2021 Apr 1;104(4):794-805. doi: 10.1093/biolre/ioab005.

    Stiffness increases with myofibroblast content and collagen density in mesenchymal high grade serous ovarian cancer. Mieulet V, Garnier C, Kieffer Y, Guilbert T, Nemati F, Marangoni E, Renault G, Chamming's F, Vincent-Salomon A, Mechta-Grigoriou F. Sci Rep. 2021 Feb 18;11(1):4219. doi: 10.1038/s41598-021-83685-0.

    Sunitinib-induced cardiac hypertrophy and the endothelin axis. Sourdon J, Facchin C, Certain A, Viel T, Robin B, Lager F, Marchiol C, Balvay D, Yoganathan T, Favier J, Tharaux PL, Dhaun N, Renault G, Tavitian B. Theranostics. 2021 Feb 6;11(8):3830-3838. doi: 10.7150/thno.49837

    Metabolomic differences in blastocoel and uterine fluids collected in vivo by ultrasound biomicroscopy on rabbit embryos. Calderari S, Daniel N, Mourier E, Richard C, Dahirel M, Lager F, Marchiol C, Renault G, Gatien J, Nadal-Desbarats L, Chavatte-Palmer P, Duranthon V. Biol Reprod. 2021 Jan 18:ioab005. doi: 10.1093/biolre/ioab005. Online ahead of print. PMID: 33459770



    Identification of a New QTL Region on Mouse Chromosome 1 Responsible for Male Hypofertility: Phenotype Characterization and Candidate Genes. Vatin M, Girault MS, Firlej V, Marchiol C, Ialy-Radio C, Montagutelli X, Vaiman D, Barbaux S, Ziyyat A. Int J Mol Sci. 2020 Nov 12;21(22):8506. doi: 10.3390/ijms21228506. PMID: 33198087

    Increased Encapsulation Efficiency of Methotrexate in Liposomes for Rheumatoid Arthritis Therapy. Guimarães D, Noro J, Loureiro A, Lager F, Renault G, Cavaco-Paulo A, Nogueira E. Biomedicines. 2020 Dec 18;8(12):630. doi: 10.3390/biomedicines8120630. PMID: 33353028

    ARID1A loss in adult hepatocytes activates β-catenin-mediated erythropoietin transcription Rozenn Riou, Meriem Ladli, Sabine Gerbal-Chaloin, Pascale Bossard, Angélique Gougelet, Cécile Godard, Robin Loesch, Isabelle Lagoutte, Franck Lager, Julien Calderaro, Alexandre Dos Santos, Zhong Wang, Frédérique Verdier, Sabine Colnot eLife. 2020; 9: e53550. Published online 2020 Oct 21. doi: 10.7554/eLife.53550

    Polymer Nanomedicines with Ph-Sensitive Release of Dexamethasone for the Localized Treatment of Inflammation Alena Libánská, Eva Randárová, Franck Lager, Gilles Renault, Daniel Scherman, Tomáš Etrych Pharmaceutics. 2020 Aug; 12(8): 700. Published online 2020 Jul 25. doi: 10.3390/pharmaceutics12080700

    Photothermal Depletion of Cancer-Associated Fibroblasts Normalizes Tumor Stiffness in Desmoplastic Cholangiocarcinoma. Nicolas Boluda A, Vaquero J, Laurent G, Renault G, Bazzi R, Donnadieu E, Roux S, Fouassier L, Gazeau F. ACS Nano. 2020 Apr 27. doi: 10.1021/acsnano.0c00417. Online ahead of print. PMID: 32338871

    Dullard-mediated Smad1/5/8 inhibition controls mouse cardiac neural crest cells condensation and outflow tract septation. Darrigrand JF, Valente M, Comai G, Martinez P, Petit M, Nishinakamura R, Osorio DS, Renault G, Marchiol C, Ribes V, Cadot B. Elife. 2020 Feb 27;9:e50325. doi: 10.7554/eLife.50325. PMID: 32105214


    Endothelial cell indoleamine 2, 3-dioxygenase 1 alters cardiac function following myocardial infarction through kynurenine, Nada Joe Melhem, Mouna Chajadine, Ingrid Gomez, Kiave-Yune Howangyin, Marion Bouvet, Camille Knosp, Yanyi Sun, Marie Rouanet, Ludivine Laurans, Olivier Cazorla, Mathilde Lemitre, José Vilar, Ziad Mallat, Alain Tedgui, Hafid Ait-Oufella, Jean- Sébastien Hulot, Jacques Callebert, Jean-Marie Launay, Jeremy Fauconnier, Jean- Sébastien Silvestre, Soraya Taleb, Circulation 2020



    Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils. Ohayon D, De Chiara A, Dang PM, Thieblemont N, Chatfield S, Marzaioli V, Burgener SS, Mocek J, Candalh C, Pintard C, Tacnet-Delorme P, Renault G, Lagoutte I, Favier M, Walker F, Hurtado-Nedelec M, Desplancq D, Weiss E, Benarafa C, Housset D, Marie JC, Frachet P, El-Benna J, Witko-Sarsat V. J Exp Med. 2019 Nov 4;216(11):2669-2687. doi: 10.1084/jem.20180371. Epub 2019 Sep 6.

    Long-term cardiovascular disorders in the STOX1 mouse model of preeclampsia. Miralles F, Collinot H, Boumerdassi Y, Ducat A, Duché A, Renault G, Marchiol C, Lagoutte I, Bertholle C, Andrieu M, Jacques S, Méhats C, Vaiman D. Sci Rep. 2019 Aug 15;9(1):11918. doi: 10.1038/s41598-019-48427-3.PMID: 31417152

    Standardised imaging pipeline for phenotyping mouse laterality defects and associated heart malformations, at multiple scales and multiple stages. Desgrange A, Lokmer J, Marchiol C, Houyel L, Meilhac SM. Dis Model Mech. 2019 Jul 9;12(7). pii: dmm038356. doi: 10.1242/dmm.038356. PMID:    31208960

    Cavitation-induced release of liposomal chemotherapy in orthotopic murine pancreatic cancer models: A feasibility study. Camus M, Vienne A, Mestas JL, Pratico C, Nicco C, Chereau C, Marie JM, Moussatov A, Renault G, Batteux F, Lafon C, Prat F. Clin Res Hepatol Gastroenterol. 2019 Nov;43(6):669-681. doi: 10.1016/j.clinre.2019.02.015. Epub 2019 Apr 26.

    β-catenin-activated hepatocellular carcinomas are addicted to fatty acids. Senni N, Savall M, Cabrerizo Granados D, Alves-Guerra MC, Sartor C, Lagoutte I, Gougelet A, Terris B, Gilgenkrantz H, Perret C, Colnot S, Bossard P. Gut. 2019 Feb;68(2):322-334. doi: 10.1136/gutjnl-2017-315448. Epub 2018 Apr 12. PMID: 29650531

    Microbubbles for Nucleic Acid Delivery in Liver Using Mild Sonoporation. Mignet N, Marie C, Delalande A, Manta S, Bureau MF, Renault G, Scherman D, Pichon C. Methods Mol Biol. 2019;1943:377-387. doi: 10.1007/978-1-4939-9092-4_25. PMID:  30838630

    The concomitant loss of APC and HNF4α in adult hepatocytes does not contribute to hepatocarcinogenesis driven by β-catenin activation. Sartor C, Bachelot L, Godard C, Lager F, Renault G, Gonzalez FJ, Perret C, Gougelet A, Colnot S. Liver Int. 2019 Apr;39(4):727-739. doi: 10.1111/liv.14068. Epub 2019 Feb 24. PMID:   30721564



    Extracellular Purine Metabolism Is the Switchboard of Immunosuppressive Macrophages and a Novel Target to Treat Diseases With Macrophage Imbalances, Repic A, Machacek C, Charvet C, Lager F, LeRoux D, Platzer R, Leska V, Mitulovic G, Burkard T, Zlabinger G, Fischer M, Feuillet V, Renault G, Blüml S, Benko M, Suchanek M, Huppa J, Matsuyama T, Cavaco-Paulo A, Bismuth G, Stockinger H, Front. Immunol., 27 April 2018 |

    Preeclampsia induced by storkhead box 1 overexpression in mice induces intrauterine growth restriction, abnormal ultrasonography and blood oxygenation level-dependent MRI signatures. Collinot H, Marchiol C, Lagoutte I, Lager F, Siauve N, Autret G, Balvay D, Renault G, Salomon LJ, Vaiman D. J Hypertens. 2018 Feb 20. doi: 10.1097/HJH.0000000000001695

    β-catenin-activated hepatocellular carcinomas are addicted to fatty acids. Senni N, Savall M, Cabrerizo Granados D, Alves-Guerra MC, Sartor C, Lagoutte I, Gougelet A, Terris B, Gilgenkrantz H, Perret C, Colnot S, Bossard P. Gut. 2018 Apr 12. pii: gutjnl-2017-315448. doi: 10.1136/gutjnl-2017-315448. PMID:   29650531



    Favouring T cell migration using nanoparticle mediated hyperthermia to modulate the tumor extracellular matrix. Nicolas-Boluda A, Barrin S, Kantari-Mimoun C, Vaquero J, Renault G, Roux S, International Conference on Nanomedicine and Nanobiotechnology 2017


    The STING agonist DMXAA triggers a cooperation between T lymphocytes and myeloid cells that leads to tumor regression, Julia M. Weiss, Marion V. Guérin, Fabienne Regnier, Gilles Renault, Isabelle Galy-Fauroux, Lene Vimeux, Vincent Feuillet, Elisa Peranzoni, Maxime Thoreau, Alain Trautmann & Nadège Bercovici OncoImmunologyPublished online: 07 Jul 2017,

    Cardiac Metabolic Deregulation Induced by the Tyrosine Kinase Receptor Inhibitor Sunitinib is rescued by Endothelin Receptor Antagonism. Sourdon J, Lager F, Viel T, Balvay D, Moorhouse R, Bennana E, Renault G, Tharaux PL, Dhaun N, Tavitian B. Theranostics. 2017 Jul 8;7(11):2757-2774. doi: 10.7150/thno.19551. eCollection 2017.

    Cationic microbubbles and antibiotic-free miniplasmid for sustained ultrasound-mediated transgene expression in liver. Manta S, Renault G, Delalande A, Couture O, Lagoutte I, Seguin J, Lager F, Houzé P, Midoux P, Bessodes M, Scherman D, Bureau MF, Marie C, Pichon C, Mignet N. J Control Release. 2017 Sep 28;262:170-181.

    Wnt proteins contribute to neuromuscular junction formation through distinct signaling pathways. Messéant J, Ezan J, Delers P, Glebov K, Marchiol C, Lager F, Renault G, Tissir F, Montcouquiol M, Sans N, Legay C, Strochlic L. Development. 2017 May 1;144(9):1712-1724.

    Dual-acting biofunctionalised scaffolds for applications in regenerative medicine. Chaves C, Gao C, Jerome Hunckler, Elsawy M, Legagneux J, Renault G, Masquelet AC, De Mel A, J Mater Sci: Mater Med (2017) 28:32, DOI 10.1007/s10856-017-5849-z

    Tumor Stiffening, a Key Determinant of Tumor Progression, is Reversed by Nanomaterial-Induced Photothermal Therapy, Marangon I, Silva A, Guilbert T,  Kolosnjaj-Tabi J, Marchiol C, Natkhunarajah S, Chamming’s F, Ménard-Moyon C, Bianco A, Gennisson JL, Renault G, Gazeau F, Theranostics. 2017; 7(2): 329–343.



    Association of FOXD1 variants with adverse pregnancy outcomes in mice and humans. Laissue P, Lakhal B, Vatin M, Batista F, Burgio G, Mercier E, Santos ED, Buffat C, Sierra-Diaz DC, Renault G, Montagutelli X, Salmon J, Monget P, Veitia RA, Méhats C, Fellous M, Gris JC, Cocquet J, Vaiman D. Open Biol. 2016 Oct;6(10). pii: 160109

    Priming Dental Pulp Stem Cells With Fibroblast Growth Factor-2 Increases Angiogenesis of Implanted Tissue-Engineered Constructs Through Hepatocyte Growth Factor and Vascular Endothelial Growth Factor Secretion, Gorin, C., Rochefort, G. Y., Bascetin, R., Ying, H., Lesieur, J., Sadoine, J., Beckouche, N., Berndt, S., Novais, A., Lesage, M., Hosten, B., Vercellino, L., Merlet, P., Le-Denmat, D., Marchiol, C., Letourneur, D., Nicoletti, A., Vital, S. O., Poliard, A., Salmon, B., Muller, L., Chaussain, C., Germain, S. Stem Cells Transl Med 2016; 5(3):392-404392-404


    Mast cells regulate myofilament calcium sensitization and heart function after myocardial infarction Anta Ngkelo, Adèle Richart, Jonathan A. Kirk, Philippe Bonnin, Jose Vilar,1 Mathilde Lemitre, Pauline Marck, Maxime Branchereau, Sylvain Le Gall, Nisa Renault, Coralie Guerin, Mark J. Ranek, Anaïs Kervadec, Luca Danelli, Gregory Gautier, Ulrich Blank, Pierre Launay, Eric Camerer, Patrick Bruneval, Philippe Menasche, Christophe Heymes, Elodie Luche, Louis Casteilla, Béatrice Cousin, Hans‑Reimer Rodewald, David A. Kass, and Jean‑Sebastien Silvestre, Journal of Experimental Medicine June 27 2016



    Enhancing methotrexate tolerance with folate tagged liposomes in arthritic mice, Nogueira E, Lager F, Le Roux D, Nogueira P,FreitasJ, Charvet C, Renault G, Loureiro A, AlmeidaCR, Ohradanova-RepicA, MachacekC, Bernardes G, Moreira A, Stockinger H, Burnet M, Carmo AM, Gomes AC, Preto A, Bismuth G and Cavaco-Paulo A, Journal of Biomedical Nanotechnology, 2015 Dec;11(12):2243-52

    Intestinal inhibition of Atg7 prevents tumor initiation through a microbiome-influenced immune response and suppresses tumor growth,  Lévy J , Cacheux W, Ait Bara M, L’hermitte A, Lepage P, Fraudeau M, Trentesaux C, Lemarchand J, Durand A, Crain AM, Marchiol C, Renault G, Dumont F, Letourneur F, Delacre M, Schmitt A, Terris B, Perret C, Chamaillard M, Couty JP, Romagnolo B, Nature Cell Biology, 2015 Aug;17(8):1062-73

    Resveratrol Decreases TXNIP mRNA and Protein Nuclear Expressions With an Arterial Function Improvement in Old Mice. Bedarida T, Baron S, Vibert F, Ayer A, Henrion D, Thioulouse E, Marchiol C, Beaudeux JL, Cottart CH, Nivet-Antoine V. J Gerontol A Biol Sci Med Sci. 2015 Jun 3

    Antitumour activity of an inhibitor of miR-34a in liver cancer with β-catenin-mutations. Gougelet A, Sartor C, Bachelot L, Godard C, Marchiol C, Renault G, Tores F, Nitschke P, Cavard C, Terris B, Perret C, Colnot S. Gut. 2015 Mar 19.

    Targeting CD226/DNAX accessory molecule-1 (DNAM-1) in collagen-induced arthritis mouse models. Elhai M, Chiocchia G, Marchiol C, Lager F, Renault G, Colonna M, Bernhardt G, Allanore Y, Avouac J. J Inflamm (Lond). 2015 Feb 8;12:9.



    High-protein-low-carbohydrate diet: deleterious metabolic and cardiovascular effects depend on age. Bedarida T, Baron S, Vessieres E, Vibert F, Ayer A, Marchiol-Fournigault C, Henrion D, Paul JL, Noble F, Golmard JL, Beaudeux JL, Cottart CH, Nivet-Antoine V. Am J Physiol Heart Circ Physiol. 2014 Sep 1;307(5):H649-57. doi: 10.1152/ajpheart.00291.2014. Epub 2014 Jul 11.

    High-frequency (20 to 40 MHz) acoustic response of liquid-filled nanocapsules. Jafari S, Diou O, Mamou J, Renault G, Fattal E, Tsapis N, Bridal SL. IEEE Trans Ultrason Ferroelectr Freq Control. 2014 Jan;61(1):5-15.



    Prokineticin receptor-1 is a new regulator of endothelial insulin uptake and capillary formation to control insulin sensitivity and cardiovascular and kidney functions. Dormishian M, Turkeri G, Urayama K, Nguyen TL, Boulberdaa M, Messaddeq N, Renault G, Henrion D, Nebigil CG. J Am Heart Assoc. 2013 Oct 23;2(5):e000411

    The dual effects of resveratrol on arterial damage induced by insulin resistance in aged mice, Baron S, Bedarida T, Vessieres E, Ayer A, Golmard JL, Vibert F, Renault G, Jardel A, Saubamea B, Henrion D, Beaudeux jl, Cottart CH, Nivet-Antoine V, J Gerontol A Biol Sci Med Sci. 2013 Jun 22.

    Cardiac Characterization of mdx Mice Using High-Resolution Doppler Echocardiography. Fayssoil A, Renault G, Guerchet N, Marchiol-Fournigault C, Fougerousse F, Richard I. J Ultrasound Med. 2013 May;32(5):757-61.

    Performance of Skin Ultrasound to Measure Skin Involvement in Different Animal Models of Systemic Sclerosis. Elhai M, Jérôme Avouac, Marchiol C, Renault G, Ruiz B, Fréchet M, Chiocchia G, Allanore Y. Ultrasound Med Biol. 2013 May;39(5):845-52.


    Refined mapping of a quantitative trait locus on chromosome 1 responsible for mouse embryonic death. Vatin M, Burgio G, Renault G, Laissue P, Firlej V, Mondon F, Montagutelli X, Vaiman D, Serres C, Ziyyat A. PLoS One. 2012;7(8):e43356.

    The chemokine decoy receptor d6 prevents excessive inflammation and adverse ventricular remodeling after myocardial infarction. Cochain C, Auvynet C, Poupel L, Vilar J, Dumeau E, Richart A, Récalde A, Zouggari Y, Yin KY, Bruneval P, Renault G, Marchiol C, Bonnin P, Lévy B, Bonecchi R, Locati M, Combadière C, Silvestre JS. Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2206-13.


    Ultrasound and microbubbles assisted gene delivery in Achilles tendons: Long lasting gene expression and restoration of fibromodulin KO phenotype. Delalande A, Bouakaz A, Renault G, Tabareau F, Kotopoulis S, Midoux P, Arbeille B, Uzbekov R, Chakravarti S, Postema M, Pichon C. J Control Release. 2011 Aug 23.




    Identification of Quantitative Trait Loci responsible for embryonic lethality in mice assessed by ultrasonography. Laissue P, Burgio G, l'Hôte D, Renault G, Marchiol-Fournigault C, Fradelizi D, Fellous M, Serres C, Montagutelli X, Monget P, Vaiman D. Int J Dev Biol. 2009;53(4):623-9.

    2008 :

    Ultrasound and Doppler micro-imaging in a model of rheumatoid arthritis in mice. Clavel G, Marchiol-Fournigault C, Renault G, Boissier MC, Fradelizi D, Bessis N. Ann Rheum Dis. 2008 Dec;67(12):1765-72.




    [High-resolution ultrasound imaging of the mouse]. Renault G, Bonnin P, Marchiol-Fournigault C, Gregoire JM, Serrière S, Richard B, Fradelizi D. J Radiol. 2006 Dec;87(12 Pt 2):1937-45. Review. French.


    A posteriori respiratory gating in contrast ultrasound for assessment of hepatic perfusion. Renault G, Tranquart F, Perlbarg V, Bleuzen A, Herment A, Frouin F. Phys Med Biol. 2005 Oct 7;50(19):4465-80.



    Communications orales dans des congrès :

    membres de la plate forme

    Renault G, Marchiol-Fournigault C, Fradelizi D, Echographie haute résolution de la souris, congrès de l’Association Française des Sciences et Techniques pour les Animaux de Laboratoires 2007 (AFSTAL 2007). Conférence Invitée.

    utilisateurs de la plate forme

    Recherche de QTL de fertilité femelle para ultrasonographie dans un modèle de souris IRCS. Troisième congrès International de Gynécologie et urologie. Bogota, Colombie, Avril 26, 27, 28, 2007

    Recherche de QTL de fertilité femelle para ultrasonographie dans un modèle de souris IRCS.  Séminaire International Santé de la Femme, Université Del Rosario, Bogota, Colombie, 5 et 6 octobre 2007.


    Posters dans des congrès :

    utilisateurs de la plate forme

    A. Fayssoil, G. Renault, C. Marchiol-Fournigault, D. Fradelizi, M. Rosier-Montus, I. Richard and F. Fougerousse, Cardiac characterization of mdx mice using high-resolution echocardiography, World Muscle Society Congress 2007 , Abstract : Neuromuscular Disorders, Volume 17, Issues 9-10, October 2007, Page 805