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    2020

    Herviou P, Le Bras M, Dumas L, Hieblot C, Gilhodes J, Cioci G, Hugnot JP, Ameadan A, Guillonneau F, Dassi E, Cammas A, Millevoi S.
    hnRNP H/F drive G-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma
    Nat Commun. 2020 May 27;11(1):2661 doi: 10.1038/s41467-020-16168-x.  Analyse quantitative de produits de Co-IP ou « AP-MS » par label-free quantification

     

    • Boussaid, S. Le Goff, C. Floquet, E-F. Gautier, A. Raimbault, P.J Viailly, D. Al Dulaimi, B. Burroni, I. Dusanter-Fourt, I. Hatin, P. Mayeux, B. Cosson & M. Fontenay.
    Integrated analyses of translatome and proteome identify the rules of translation selectivity in RPS14-deficient cells.
    Haematologica, sous presse. doi: 10.3324/haematol.2019.239970. Analyse quantitative globale par Label-Free.

     

    Morgane Oudot, Pascal Neige, Ira Ben Shir, Asher Schmidt, Jan M Strugnell, Laurent Plasseraud, Cédric Broussard, René Hoffmann, Alexander Lukeneder, Frédéric Marin.
    The shell matrix and microstructure of the Ram’s Horn squid: molecular and structural characterization.
    Journal of Structural Biology. 2020 Apr 15:107507. doi: 10.1016/j.jsb.2020.107507. Identifications de protéines issues de bandes SDS PAGE.

     

    Jorune Sakalauskaite, Laurent Plasseraud, Jérôme Thomas, Marie Albéric, Mathieu Thoury, Jonathan Perrin, Frédéric Jamme, Cédric Broussard, Beatrice Demarchi, Frédéric Marin.
    The shell matrix of the European thorny oyster, Spondylus gaederopus: microstructural and molecular characterization.
    Journal of Structural Biology. 2020 Mar 24:107497. doi: 10.1016/j.jsb.2020.107497. Identifications de protéines issues de bandes SDS PAGE.

     

    • Emilie-Fleur Gautier*, Marjorie Leduc*, Meriem Ladli, Vincent P. Schulz, Carine Lefevre, Michaela Fontenay, Catherine Lacombe, Frédérique Verdier, François Guillonneau, Narla Mohandas, Patrick G. Gallagher and Patrick Mayeux
    Comprehensive proteomic analysis of murine erythroid differentiation reveals limited divergences with human erythropoiesis
    Accepted in Blood advances . *co 1st authors analyse quantitative globale et comparée des changements cellulaires au cours de la différenciation érythroide chez l’humain et la souris par « label-free absolute quantification«

     

    • Hermand P, Azouzi S, Gautier EF, Guillonneau F, Bondet V, Duffy D, Dechavanne S, Tharaux PL, Mayeux P, Le Van Kim C, Koehl B.
    The proteome of neutrophils in sickle cell disease reveals an unexpected activation of interferon alpha signaling pathway.
    Haematologica . 2020 Mar 5. pii : haematol.2019.238295. doi : 10.3324/haematol.2019.238295 analyse quantitative globale par « label-free quantification« .

     

    • Sohier P, Sanson R, Leduc M, Audebourg A, Broussard C, Salnot V, Just PA, Pasmant E, Mayeux P, Guillonneau F, Romagnolo B, Perret C, Terris B.
    Proteome analysis of formalin-fixed paraffin-embedded colorectal adenomas reveals the heterogeneous nature of traditional serrated adenomas relative to other colorectal adenomas.
    ! Couverture de J Pathol 2020 Mar ;250(3):251-261. doi : 10.1002/path.5366 . Analyse protéomique Label-free de tissus fixé et inclus en paraffine (coupes FFPE). Lisez le focus sur le site de l’institut Cochin

     

    • Maud de Dieuleveult, Marjorie Leduc, Eralda Salataj, Céline Ransy, Julien Dairou, Kengo Homma, Morgane Le Gall, Pascale Bossard, Anne Lombès, Frédéric Bouillaud, Laure Ferry, Pierre-Antoine Defossez, Jean-Charles Cadoret, Hidenori Ichijo, Stephen A. Wood, François Guillonneau, Ralf Dressel, Benoit Miotto
    USP9X deubiquitinase couples the pluripotency network and cell metabolism to regulate ESC differentiation potential
    biorxiv.org doi : 2020.01.13.904904

     

    • Azouzi S, Mikdar M, Hermand P, Gautier EF, Salnot V, Willemetz A, Nicolas G, Vrignaud C, Raneri A, Mayeux P, Bole-Feysot C, Nitschké P, Cartron JP, Colin Y, Hermine O, Jedlitschky G, Cloutier M, Constanzo-Yanez J, Ethier C, Robitaille N, St-Louis M, Le Van Kim C, Peyrard T.
    Lack of the multidrug transporter MRP4/ABCC4 defines the PEL-negative blood group and impairs platelet aggregation.
    Blood.  2020 Feb 6;135(6):441-448. 11. pii : blood.2019002320. doi : 10.1182/blood.2019002320Label-free detection and quantification of rare blood group proteins and mutant proteins of the erythrocyte cell surface.

     

    • Rouis O, Broussard C, Guillonneau F, Boulé JB, Delagoutte E.
    Identification of hemicatenane-specific binding proteins by fractionation of Hela nuclei extracts.
    Biochem J. 2020 Jan 13. pii : BCJ20190855. doi : 10.1042/BCJ20190855 Analyse de protéines se fixant a des structures particulières d’ADN par AP-MS

     

    • Ahmad R, Lahuna O, Sidibe A, Daulat A, Zhang Q, Luka M, Guillaume JL, Gallet S, Guillonneau F, Hamroune J, Polo S, Prévot V, Delagrange P, Dam J, Jockers R.
    GPR50-Ctail cleavage and nuclear translocation : a new signal transduction mode for G protein-coupled receptors.
    Cell Mol Life Sci . 2020 Jan 3. doi : 10.1007/s00018-019-03440-7 . MALDI MS characterization of calpain cleavage capacity on GPR50 peptide sequence

     

    • Malerba M, Louis S, Cuvellier S, Shambat SM, Hua C, Gomart C, Fouet A, Ortonne N, Decousser JW, Zinkernagel AS, Mathieu JR, Peyssonnaux C.
    Epidermal hepcidin is required for neutrophil response to bacterial infection.
    Remerciement in J Clin Invest. 2020 Jan 2 ;130(1):329-334. doi : 10.1172/JCI126645. MALDI-MS measurements of peptides after protease-induced cleavage Lisez le focus sur le site de l’institut Cochin

     

    2019

    • Lorès P, Dacheux D, Kherraf ZE, Nsota Mbango JF, Coutton C, Stouvenel L, Ialy-Radio C, Amiri-Yekta A, Whitfield M, Schmitt A, Cazin C, Givelet M, Ferreux L, Fourati Ben Mustapha S, Halouani L, Marrakchi O, Daneshipour A, El Khouri E, Do Cruzeiro M, Favier M, Guillonneau F, Chaudhry M, Sakheli Z, Wolf JP, Patrat C, Gacon G, Savinov SN, Hosseini SH, Robinson DR, Zouari R, Ziyyat A, Arnoult C, Dulioust E, Bonhivers M, Ray PF, Touré A.
    Mutations in TTC29, encoding an evolutionary conserved axonemal protein, result in asthenozoospermia and male infertility.
    Am J Hum Genet Dec 5;105(6):1148-1167. doi : 10.1016/j.ajhg.2019.10.007. Identification and label free quantification of axonemal proteins from purified flagella preparations.

     

    • Barbosa da Cruz D, Helms J, Aquino LR, Stiel L, Cougourdan L, Broussard CChafey P, Riès-Kautt M, Meziani F, Toti F, Gaussem P, Anglés-Cano E.
    DNA-bound elastase of Neutrophil Extracellular Traps degrades plasminogen and affects the potential for fibrinolysis by reducing plasmin formation.
    FASEB Journal. 2019 Nov 4. doi : 10.1096/fj.201901363RRR. Décryptage des fragments du plasminogen par l’elastase lors de la formation de NET in vitro.

     

    • Ohayon D, De Chiara A, My-Chan Dang P, Thieblemont N, Chatfield S, Marzaioli V, Burgener SS, Mocek J, Candalh C, Pintard C, Tacnet-Delorme P, Renault G, Lagoutte I, Favier M, Walker F, Hurtado-Nedelec M, Desplancq D, Weiss E, Benarafa C, Housset D, Marie JC, Frachet P, El-Benna J, Witko-Sarsat V.
    Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils.
    Remerciements dans J Exp Med. 2019 Dec 2 ;216(12):2900. doi : 10.1084/jem.2018037111082019c Identifications de protéines se fixant a PCNA par AP-MS. Lisez le focus sur le site de l’institut Cochin.

     

    • Virion Z, Doly S, Saha K, Lambert M, Guillonneau F, Bied C, Duke RM, Rudd PM, Robbe-Masselot C, Nassif X, Coureuil M, Marullo S.
    Sialic acid-mediated mechanical activation of β2 adrenergic receptors by bacterial pili.
    Nat. Comm. 2019 Oct 18 ;10(1):4752. doi : 10.1038/s41467-019-12685-6. Selective digestion, enrichment and detection of Sialic acid-bearing β2-AR peptides. Lisez le focus sur le site de l’institut Cochin.

     

    • Delort, F., Segard, B.-D., Hakibilen, C., Bourgois-Rocha, F., Cabet, E., Vicart P, Huang ME, Clary G, Lilienbaum A, Agbulut O, Batonnet-Pichon S.
    Alterations of redox dynamics and desmin post-translational modifications in skeletal muscle models of desminopathies.
    Exp Cell Res. 2019 Oct 15 ;383(2):111539. doi : 10.1016/j.yexcr.2019.111539. 2D Gel electrophoresis separation of protein isoforms.

     

    • Bondu S, Alary AS, Lefèvre C, Houy A, Jung G, Lefebvre T, Rombaut D, Boussaid I, Bousta A, Guillonneau F, Perrier P, Alsafadi S, Wassef M, Margueron R, Rousseau A, Droin N, Cagnard N, Kaltenbach S, Winter S, Kubasch AS, Bouscary D, Santini V, Toma A, Hunault M, Stamatoullas A, Gyan E, Cluzeau T, Platzbecker U, Adès L, Puy H, Stern MH, Karim Z, Mayeux P, Nemeth E, Park S, Ganz T, Kautz L, Kosmider O, Fontenay M.
    A variant erythroferrone disrupts iron homeostasis in SF3B1-mutated myelodysplastic syndrome.
    Science Translational Medicine 2019 Jul 10 ;11(500). pii : eaav5467. doi : 10.1126/scitranslmed.aav5467. Analyse protéogénomique ciblée de peptides modifiés chez des patients ayant une altération du splicing alternatif. Brevet EP19305047.3.  Date de dépôt : 16/01/2019 Lisez le focus sur le site de l’institut Cochin.

     

    • Chaigne B, Clary G, Le Gall M, Dumoitier N, Fernandez C, Lofek S, Chafey P, Moinzadeh P, Krieg T, Denton CP, Mouthon L.
    Proteomic analysis of human scleroderma fibroblasts response to transforming growth factor-ß.
    J Proteomics – Clinical Applications
    2019 Jul;13(4):e1800069. doi : 10.1002/prca.2018000692D-DIGE et bioanalysis.

     

    • Pagnout C, Sohm B, Razafitianamaharavo A, Caillet C, Offroy M, Leduc M, Gendre H, Jomini S, Beaussart A, Bauda P, Duval JFL.
    Pleiotropic effects of rfa-gene mutations on Escherichia coli envelope properties.
    Scientific Reports 2019 Jul 4 ;9(1):9696. doi : 10.1038/s41598-019-46100-3Analyse quantitative relative globale par « iTRAQ ».

     

    • Kamaliddin C, Rombaut D, Guillochon E, Royo J, Ezinmegnon S, Agbota G, Huguet S, Guemouri S, Peirera C, Coppée R,Broussard C, Alao J, Aubouy A, Guillonneau F, Deloron P, Bertin G.
    From genomic to LC-MS/MS evidence : analysis of PfEMP1 in Benin malaria cases
    Plos One 2019 Jun 28 ;14(6):e0218012. doi : 10.1371/journal.pone.0218012. eCollection 2019. Analyse protéogénomique chez des patients génotypés atteints de Malaria.

     

    • Demarta-Gatsi C, Rivkin A, Di Bartolo V, Peronet R, Ding S, Commere PH, Guillonneau F, Bellalou J, Brûlé S, Abou Karam P, Cohen SR, Lagache T, Janse CJ, Regev-Rudzki N, Mécheri S.
    Histamine releasing factor and elongation factor 1 alpha secreted via malaria parasites extracellular vesicles promote immune evasion by inhibiting specific T cell responses.
    Cell Microbiol. 2019 Mar 5:e13021. doi : 10.1111/cmi.13021. Extracellular vesicles analysis.

     

    • Everts-Graber J, Martin KR, Thieblemont N, Mocek J, Roccabianca A, Chafey P, Le Gall M, Tacnet-Delorme P, Reutelingsperger CP, Naccache JM, Bonnotte B, Karras A, Puéchal X, Guillevin L, Terrier B, Frachet P, Perretti M, Mouthon L, Witko-Sarsat V.
    Proteomic analysis of neutrophils in ANCA-associated vasculitis reveals a dysregulation in proteinase 3-associated proteins such as annexin-A1 involved in apoptotic cell clearance.
    Kidney Int. 2019 Aug;96(2):397-408. doi : 10.1016/j.kint.2019.02.017.

     

    • Mouasni S, Gonzalez V, Schmitt A, Bennana E, Guillonneau F, Mistou S, Avouac J, Ea HK, Devauchelle V, Gottenberg JE, Chiocchia G, Tourneur L.
    The classical NLRP3 inflammasome controls FADD unconventional secretion through microvesicle shedding.
    Cell Death Dis. 2019 Feb 25 ;10(3):190. doi : 10.1038/s41419-019-1412-9Extracellular vesicles analysis.

     

    • Oudot C, Gomes A, Nicolas V, Le Gall M, Chafey P, Broussard C, Calamita G, Mastrodonato M, Gena P, Perfettini JL, Hamelin J, Lemoine A, Fischmeister R, Vieira H, Santos C, Brenner C.
    CSRP3 Mediates Polyphenols-Induced Cardioprotection In Hypertension.
    The Journal of Nutritional Biochemistry . 2019 Apr ;66:29-42. doi : 10.1016/j.jnutbio.2019.01.001. 2D-DIGE.

     

    2018

    • Gachet S, El-Chaar T, Avran D, Genesca E, Catez F, Quentin S, Delord M, Thérizols G, Briot D, Meunier G, Hernandez L, Pla M, Smits WK, Buijs-Gladdines JG, Van Loocke W, Menschaert G, André-Schmutz I, Taghon T, Van Vlierberghe P, Meijerink JP, Baruchel A, Dombret H, Clappier E, Diaz JJ, Gazin C, de Thé H, Sigaux F, Soulier J.
    Deletion 6q drives T-cell leukemia progression by ribosome modulation.
    Remerciements dans Cancer Discovery 2018 Sep 28. pii : CD-17-0831. DOI : 10.1158/2159-8290.CD-17-0831 portant sur l’analyse quantitative relative globale par « label-free quantification« .

     

    • Emilie-Fleur Gautier, Marjorie Leduc, Sylvie Cochet, Karine Bailly, Catherine Lacombe Narla Mohandas, François Guillonneau, Wassim el-Nemer and Patrick Mayeux.
    Absolute proteome quantification of highly purified populations of circulating reticulocytes and mature erythrocytes.
    Blood advances (2018 2:2646-2657). DOI : 10.1182/bloodadvances.2018023515. Analyse quantitative absolue globale par « label-free absolute quantification« .

     

    • Tavernier Q, Bennana E, Poindessous V, Schaeffer C, Rampoldi L, Pietrancosta N, Pallet N.
    Regulation of IRE1 RNase activity by the Ribonuclease inhibitor 1 (RNH1).
    Cell Cycle 2018 Aug. doi.org/10.1080/15384101.2018.1506655.

     

    • Weckel A, Ahamada D, Bellais S, Méhats C, Plainvert C, Longo M, Poyart C, Fouet A.
    The N-terminal domain of the R28 protein promotes emm28 Group A Streptococcus adhesion to host cells via direct binding to three integrins.
    Remerciements dans JBC 2018 Aug 27. doi : 10.1074/jbc.RA118.004134Analyse de partenaires issus de Co-ImmunoPurifications par AP-MS.

     

    • Chougui G, Munir-Matloob S, Matkovic R, Martin MM, Morel M, Lahouassa H, Leduc M, Ramirez BC, Etienne L, Margottin-Goguet F.
    HIV-2/SIV viral protein X counteracts HUSH repressor complex.
    Nature Microbiology 2018 Jun 11. doi : 10.1038/s41564-018-0179-6Analyse quantitative relative par SILAC. Voir aussi le focus sur le site de l’institut Cochin

     

    • Marjorie Leduc, Emilie-Fleur Gautier, Anissa Guillemin, Cédric Broussard, Virginie Salnot, Catherine Lacombe, Olivier Gandrillon, François Guillonneau and Patrick Mayeux.
    Deep proteomic analysis of chicken erythropoiesis.
    Dépôt sur www.biorxiv.org doi:10.1101/289728. Analyse quantitative globale des changements cellulaires par « label-free absolute quantification« .

     

    • Mégane Brusson Maria De Grandis, Sylvie Cochet, Sylvain Bigot, Mickaël Marin, Marjorie Leduc, François Guillonneau, Patrick Mayeux, Thierry Peyrard, Christine Chomienne, Caroline Le Van Kim, Bruno Cassinat, Jean-Jacques Kiladjian and Wassim El Nemer
    Impact of hydroxycarbamide and interferon-α on red cell adhesion and membrane protein expression in Polycythemia Vera.
    Haematologica 2018 103 : 972-981. doi : 10.3324/haematol.2017.182303. iTRAQ relative quantification of erythrocyte membrane proteins (ghosts).

     

     • Stefanie Wojciech , Raise Ahmad , Zakia Belaid-Choucair , Anne-Sophie Journé , Sarah Gallet , Julie Dam , Avais Daulat , Delphine Ndiaye-Lobry , Olivier Lahuna , Angeliki Karamitri , Jean-Luc Guillaume , Marcio Do Cruzeiro , François Guillonneau , Anastasia Saade , Nathalie Clement , Thomas Courivaud , Nawel Kaabi , Kenjiro Tadagaki , Philippe Delagrange , Vincent Prevot , Olivier Hermine , Céline Prunier, Ralf Jockers.
    The orphan GPR50 receptor promotes constitutive TGFβ receptor signaling and protects against cancer development.
    Nature communications 2018 Mar 23 ;9(1):1216. doi : 10.1038/s41467-018-03609-x. Analyse de partenaires issus de Co-IP par TAP-Tag et analysés en nLC-MALDI-TOF/TOF.

     

    • Coyac BR, Hoac B, Chafey P, Falgayrac G, Slimani L, Rowe PS, Penel G, Linglart A, McKee MD, Chaussain C, Bardet C.
    Defective Mineralization in X-Linked Hypophosphatemia Dental Pulp Cell Cultures.
    Journal of Dental Research 2018 Feb ;97(2):184-191. doi : 10.1177/0022034517728497. Analyses 1D western.

     

    2017

    • Anastácio A, Rodriguez-Wallberg KA, Chardonnet S, Pionneau C, Fédérici C, Almeida Santos T, Poirot C.
    Protein profile of mouse ovarian follicles grown in vitro.
    Mol Hum Reprod. 2017 Dec 1 ;23(12):827-841. doi : 10.1093/molehr/gax056 Analyse ontologique

     

    • Kamaliddin C, Salnot V, Leduc M, Ezinmegnon S, Broussard C, Fievet N, Deloron P, Guillonneau F, Bertin GI.
    PFI1785w : a higly conserved protein associated with Pregnancy Associated Malaria
    PLOS ONE , 2017 Nov 9 ;12(11):e0187817. doi : 10.1371/journal.pone.0187817 Quantification en t-sim de protéines discriminantes d’un paludisme associé à la grossesse

     

    • Dorard E, Chasseigneaux S, Gorisse-Hussonnois L, Broussard C, Pillot T, Allinquant B.
    Soluble Amyloid Precursor Protein alpha interacts with alpha3-Na, K-ATPAse to induce axonal outgrowth but not neuroprotection : Evidence for distinct mechanisms underlying these properties
    Molecular Neurobiology , 2017 Vol. 55 (7), 5594–5610 doi : 10.1007/s12035-017-0783-0 Analyse de partenaires issus de Co-IP sélectionnés sur gel et analysés en nLC-MALDI-TOF/TOF


    • Harford-Wright E, Andre-Gregoire G, Jacobs KA, Treps L, Le Gonidec S, Leclair HM, Gonzalez-Diest S, Roux Q, Guillonneau F, Loussouarn D, Oliver L, Vallette FM, Foufelle F, Valet P, Davenport AP, Glen RC, Bidere N, Gavard J.
    Pharmacological targeting of apelin impairs glioblastoma growth
    Brain , 2017 Nov 1 ;140(11):2939-2954 doi : 10.1093/brain/awx253 analyse nLC-MALDI-TOF/TOF de peptidome de lignées modèles de la barrière hémato-encephalique (BBB)

     

    • Dombret C, Capela D, Poissenot K, Parmentier C, Bergsten E, Pionneau C, Chardonnet S, Hardin-Pouzet H, Grange-Messent V, Keller M, Franceschini I, Mhaouty-Kodja S.
    Neural Mechanisms Underlying the Disruption of Male Courtship Behavior by Adult Exposure to Di(2-ethylhexyl) Phthalate in Mice. Remerciements dans Environ Health Perspect. 2017 Sep 1 ;125(9):097001. doi : 10.1289/EHP1443 Analyse ontologique

     

    • Hospital MA, Jacquel A, Mazed F, Saland E, Larrue C, Mondesir J, Birsen R, Green AS, Lambert M, Sujobert P, Gautier EF, Salnot V, Le Gall M, Decroocq J, Poulain L, Jacque N, Fontenay M, Kosmider O, Récher C, Auberger P, Mayeux P, Bouscary D, Sarry JE, Tamburini J.
    RSK2 is a new Pim2 target with pro-survival functions in FLT3-ITD-positive acute myeloid leukemia
    Leukemia 2017 vol. 32, 597–605. doi : 10.1038/leu.2017.284 Analyse par label-free quantification de lignées leucémiques et analyse ontologique


    • Terrier B, Colombat M, Beugnet C, Quéant A, London J, Daudin JB, Le Jeunne C, Mouthon L, Monnet D, Cauquil C, Lacroix C, Adams D, Brézin A, Valleix S.
    Vitreous amyloidosis with autonomic neuropathy of the digestive tract associated with a novel transthyretin p.Gly87Arg variant in a Bangladeshi patient : a case report.
    Ghost authorship in J Med Case Rep. 2017 Aug 13 ;11(1):222. doi : 10.1186/s13256-017-1407-z. Identification de protéines responsables de pathologies cliniques à dépôts de protéines


    • Sourdon J, Lager F, Viel T, Balvay D, Moorhouse R, Bennana E, Renault G, Tharaux PL, Dhaun N, Tavitian B.
    Cardiac Metabolic Deregulation Induced by the Tyrosine Kinase Receptor Inhibitor Sunitinib is rescued by Endothelin Receptor Antagonism
    Theranostics 2017 Jul 8 ;7(11):2757-2774. doi : 10.7150/thno.19551 Analyse par label-free quantification de tissu cardiaque et analyse ontologique

     

    • Frazao A, Colombo M, Fourmentraux-Neves E, Messaoudene M, Rusakiewicz S, Zitvogel L, Vivier E, Vély F, Faure F, Dréno B, Benlalam H, Bouquet F, Savina A, Pasmant E, Toubert A, Avril MF, Caignard A.
    Shifting the Balance of Activating and Inhibitory Natural Killer Receptor Ligands on BRAFV600E Melanoma Lines with Vemurafenib.
    Remerciements dans Cancer Immunol Res. 2017 Jul ;5(7):582-593. doi : 10.1158/2326-6066.CIR-16-0380 analyses phosphoERK par nanopro


    • Moretti C, Serrentino ME, Ialy-Radio C, Delessard M, Soboleva TA, Tores F, Leduc M, Nitschké P, Drevet JR, Tremethick DJ, Vaiman D, Kocer A, Cocquet J.
    SLY regulates genes involved in chromatin remodeling and interacts with TBL1XR1 during sperm differentiation.
    Cell Death Differ. 2017 Jun ;24(6):1029-1044 doi : 10.1038/cdd.2017.32Analyse de partenaires issus de Co-IP


    • Maïssa N, Covarelli V, Janel S, Durel B, Simpson N, Bernard SC, Pardo-Lopez L, Bouzinba-Ségard H, Faure C, Scott MGH, Coureuil M, Morand PC, Lafont F, Nassif X, Marullo S, Bourdoulous S.
    Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/β2-adrenoceptor clusters assembled by alpha-actinin-4.
    Remerciements dans Nature Communication 2017 Jun 1 ;8:15764. doi : 10.1038/ncomms15764 Analyse de partenaires issus de Co-IP sélectionnés sur gel et analysés en nLC-MALDI-TOF/TOF

     

    • Zhou Z, Xu L, Sennepin A, Federici C, Ganor Y, Tudor D, Damotte D, Barry Delongchamps N, Zerbib M, Bomsel M.
    The HIV-1 viral synapse signals human foreskin keratinocytes to secrete thymic stromal lymphopoietin facilitating HIV-1 foreskin entry.
    Mucosal Immunology 2017 Apr 26. doi : 10.1038/mi.2017.23 Analyse ontologique

     

    • Brusson M, Cochet S, Leduc M, Guillonneau F, Mayeux P, Peyrard T, Chomienne C, Le Van Kim C, Cassinat B, Kiladjian JJ, El Nemer W.
    Enhanced calreticulin expression in red cells of polycythemia vera patients harboring the JAK2V617F mutation
    Haematologica 102(7):e241-e244. doi : 10.3324/haematol.2016.161604 iTRAQ relative quantification of erythrocyte membrane proteins (ghosts)

     

    • Jeannot P, Nowosad A, Perchey RT, Callot C, Bennana E, Katsube T, Mayeux P, Guillonneau F, Manenti S, Besson A.
    p27Kip1 promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway
    Elife 13 ;6. pii : e22207. doi : 10.7554/eLife.22207 identification de phosphosites sur protéines surexprimées

     

    • Régent A, Ly KH, Groh M, Khifer C, Lofek S, Clary G, Chafey P, Baud V, Broussard C, Federici C, Labrousse F, Mesturoux L, Le Jeunne C, Vidal E, Brezin A, Witko-Sarsat V, Guillevin L, Mouthon L.
    Molecular analysis of vascular smooth muscle cells from patients with giant cell arteritis : Targeting endothelin-1 receptor to control proliferation.
    Autoimmun Rev. pii : Apr ;16(4):398-406. doi : 10.1016/j.autrev.2017.02.006. Review. Analyse quantitative relative par 2D DIGE et analyse ontologique


    • Dambrun M, Dechavanne C, Emmanuel A, Aussenac F, Leduc M, Giangrande C, Vinh J, Dugoujon JM, Lefranc MP, Guillonneau F*, Migot-Nabias F*. (*co last authors)
    Human immunoglobulin heavy gamma chain polymorphisms : molecular confirmation of proteomic assessment.
    Molecular & Cellular Proteomics 16, 824-839. doi : 10.1074/mcp.M116.064733Determination of IgHG-1, -2, -3 and -4 heavy chains polymorphism

     

    • Naudin C, Hattabi A, Michelet F, Miri-Nezhad A, Benyoucef A, Pflumio F, Guillonneau F, Fichelson S, Vigon I, Dusanter-Fourt I, Lauret E.
    PUMILIO/FOXP1 signaling drives expansion of hematopoietic stem/progenitor and leukemia cells
    Blood 129:2493-2506 ; doi:10.1182/blood-2016-10-747436 Analyse quantitative relative par SILAC de lignées sh pumilio et analyse ontologique

     

    • Leclerc, E., Kimura, K., Shinohara, M., Danoy, M., Le Gall, M., Kido, T., Miyajima, A., Fujii, T., Sakai, Y.
    Comparison of the transcriptomic profile of hepatic human induced pluripotent stem like cells cultured in plates and in a 3D microscale dynamic environment
    Genomics 109(1):16-26 DOI:10.1016/j.ygeno.2016.11.008 Analyse ontologique

     

    • André W, Nondier I, Valensi M, Guillonneau F, Federici C, Hoffner G, Djian P.
    Identification of brain substrates of transglutaminase by functional proteomics supports its role in neurodegenerative diseases
    Neurobiology of Disease 101:40-58. doi:10.1016/j.nbd.2017.01.007 nLC-MALDI-TOF/TOF identification of transglutaminase substrates captured by affinity purification (AP-MS)

     

    • Nevo N, Thomas L, Chhuon C, Andrzejewska Z, Lipecka J, Guillonneau F, Bailleux A, Edelman A, Antignac C, Guerrera IC.
    Impact of cystinosin glycosylation on protein stability by differential dynamic SILAC
    Mol Cell Proteomics 16(3):457-468 doi:10.1074/mcp.M116.0638676 pulsed SILAC experiment to determine protein turnover

     

    2016

    • Belyy A, Raoux-Barbot D, Saveanu C, Namane A, Ogryzko V, Worpenberg L, David V, Henriot V, Fellous S, Merrifield C, Assayag E, Ladant D, Renault L, Mechold U.
    Actin activates Pseudomonas aeruginosa ExoY nucleotidyl cyclase toxin and ExoY-like effector domains from MARTX toxins.
    remerciements dans Nat. Commun. 7, 13582 doi : 10.1038/ncomms13582LC-MS identification and quantification of proteins captured by TAP-tag (AP-MS)

     

    • Naissant B, Dupuy F, Duffier Y, Lorthiois A, Duez J, Scholz J, Buffet P, Merckx A, Bachmann A, Lavazec C.
    Plasmodium falciparum STEVOR phosphorylation regulates host erythrocyte deformability enabling malaria parasite transmission.
    Remerciements in Blood 127:e42-e53 ; doi:10.1182/blood-2016-01-690776Analyse de partenaires issus de Co-IP

     

    • Ohlmann P, Hechler B, Chafey P, Ravanat C, Isola H, Wiesel ML, Cazenave JP, Gachet C.
    Hemostatic properties and protein expression profile of therapeutic apheresis plasma treated with amotosalen and ultraviolet A for pathogen inactivation.
    Transfusion  ;56(9):2239-47. doi : 10.1111/trf.13670.2D DIGE quantitative proteome analysis

     

    • Mouchi V, Lartaud F, Guichard N, Immel F, de Rafélis M, Broussard C, Crowley Q, Marin F.
    Chalky versus foliated : a discriminant immunogold labelling of shell microstructures in the edible oyster Crassostrea gigas.
    Marine Biology 163:256 DOI 10.1007/s00227-016-3040-6 identifications de protéines issues de SDS PAGE

     

    • Ohayon D, De Chiara A, Chapuis N, Candalh C, Mocek J, Ribeil J-A, Haddaoui L, Ifrah N, Hermine O, Bouillaud F, Frachet P, Bouscary D, Witko-Sarsat V.
    Cytoplasmic proliferating cell nuclear antigen connects glycolysis and cell survival in acute myeloid leukemia.
    Remerciements dans Scientific Reports 6, Article number : 35561 (2016) doi:10.1038/srep35561 Affinity purification-MS ou identification de protéines partenaires par Co-ImmunoPurification


    • Tiotiu A, Brazdova A, Longé C, Gallet P, Morisset M, Leduc V, Hilger C, Broussard C, Couderc R, Sutra JP, Sénéchal H, Poncet P.
    Urtica dioica pollen allergy : clinical, biological and allergomics analysis. 
    Annals of Allergy, Asthma & Immunology . Volume 117, Issue 5, November 2016, Pages 527–534. Doi:10.1016/j.anai.2016.09.426 identifications de protéines issues de SDS PAGE

     

    • Régent A, Ly K, Lofek S, Clary G, Tamby M, Tamas N, Federici C, Broussard C, Chafey P, Liaudet-Coopman E, Humbert M, Perros F, Mouthon L.
    Proteomic analysis of vascular smooth muscle cells in physiological condition and in pulmonary arterial hypertension : toward contractile versus synthetic phenotypes. 
    Proteomics doi : 10.1002/pmic.2015000062D-DIGE.

     

    • Emilie-Fleur Gautier, Sarah Ducamp, Marjorie Leduc, Virginie Salnot, François Guillonneau, Michael Dussiot, John Hale, Marie-Catherine Giarratana, Anna Raimbault, Luc Douay, Catherine Lacombe, Narla Mohandas, Frédérique Verdier, Yael Zermati, Patrick Mayeux
    Comprehensive Proteomic Analysis of Human Erythropoiesis
    Cell Reports 16(5):1470-1484, DOI:10.1016/j.celrep.2016.06.085 analyse quantitative globale des changements cellulaires par « label-free absolute quantification » et iTRAQ Voir aussi le focus sur le site de l’institut Cochin


    • Gwladys I. Bertin, Audrey Sabbagh, Nicolas Argy, Virginie Salnot, Sem Ezinmegnon, Gino Agbota, Yélé Ladipo, Jules M. Alao, Gratien Sagbo, François Guillonneau, Philippe Deloron
    Proteomic analysis of Plasmodium falciparum parasites from patients with cerebral and uncomplicated malaria
    Scientific Reports Jun 1 ;6:26773 DOI : 10.1038/srep26773Comparaison de contenus en protéines issues d’hématies parasitées

     

    • Maravic A, Cvjetan S, Konta M, Ladouce R, Martin F.A.
    Proteomic response of a β-lactamases-producing Enterobacter cloacae complex strain to cefotaxime-induced stress. 
    Remerciements dans Pathogens and Disease DOI : 10.1093/femspd/ftw045 identifications de protéines issues de 2D-DIGE.

     

    • Nikolic A, Peric M, Ladouce R, Mikecin A.M, Martin F.A, Kralj M, Krisko A and Radman M.
    Death by UVC Light Correlates with Protein Damage in Isogenic Human Tumor Cells : Primary Tumor SW480 versus its Metastasis SW620. 
    Journal of Proteomics & Computational Biology 2(1), 12 identifications de protéines issues de 2D-DIGE.

     

    • Hichem Lahouassa, Marie-Lise Blondot, Lise Chauveaud, Ghina Chouguia, Marina Morela, Marjorie Leduc, François Guillonneau, Bertha Cecilia Ramirez, Olivier Schwartz and Florence Margottin-Goguet
    HIV-1 Vpr degrades the HLTF DNA translocase in T cells and macrophages 
    Proc Natl Acad Sci U S A 113(19):5311-6. DOI : DOI:10.1073/pnas.1600485113 Analyse quantitative relative par SILAC. Voir aussi le focus sur le site de l’institut Cochin

     

    • Immel F, Broussard C, Catherinet B, Plasseraud L, Alcaraz G, Bundeleva I and Marin F.
    The shell of the invasive bivalve species Dreissena polymorpha : biochemical, elemental and textural investigations.
    PLOS ONE DOI:10.1371/journal.pone.0154264

     

    • Berthelot V, Mouta-Cardoso G, Hégarat N, Guillonneau F, François JC, Giovannangeli C, Praseuth D, and Rusconi F
    The human DNA ends proteome uncovers an unexpected entanglement of functional pathways.
    Nucl. Acids Res. 44(10):4721-33 DOI:10.1093/nar/gkw121 Identification de composition de complexes proteiques issus de BN PAGE.

     

    • Pieri L, Chafey P, Le Gall M, Clary G, Melki R, Redeker V.
    Cellular response of human neuroblastoma cells to α-synuclein fibrils, the main constituent of Lewy bodies.
    Biochim Biophys Acta . 2016 Jan ;1860(1 Pt A):8-19. DOI:10.1016/j.bbagen.2015.10.007.

     

    2015

    • Boumaiza M, Jaouen M, Deschemin JC, Ezzine A, Ben Khalaf N, Vaulont S, Marzouki MN, Sari MA.
    Expression and purification of a new recombinant camel hepcidin able to promote the degradation of the iron exporter ferroportin1.
    Remerciements dans Protein Expr Purif. 2015 Nov ;115:11-8. doi : 10.1016/j.pep.2015.04.016Analyses MALDI TOF TOF

     

    • B Hechler, C Ravanat, P Ohlmann, A Eckly, M Leduc, F Guillonneau, H Isola, C Gachet
    L’inactivation des pathogènes par la technologie Intercept® préserve l’ultrastructure et les propriétés biochimiques des plaquettes au cours de leur conservation en vue de transfusion.
    Transfusion Clinique et Biologique 2015 sep 30 22(4) p222 doi : 10.1016/j.tracli.2015.06.026 Analyse quantitative du protéome des plaquettes par iTRAQ et ESI MS/MS


    • Parker A, Immel F, Guichard N, Broussard C, Marin F.
    Thermal stability of nacre proteins of the Polynesian pearl oyster : a proteomic study.
    Key Engineering Materials Vol. 672 (2015) pp 222-231. Electrophorèse.

     

    • Dutoit-Lefèvre V, Dubucquoi S, Launay D, Dussart P, Chafey P, Broussard C, Duban-Deweer S, Vermersch P, Prin L, Lefranc D.
    An Optimized Fluorescence-Based Bidimensional Immunoproteomic Approach for Accurate Screening of Autoantibodies.
    Plos One 10.1371/journal.pone.0132142. doi: 10.1371/journal.pone.01321422D-DIGE.

     

    • Monlezun L, Phan G, Benabdelhak H, Lascombe MB, Enguéné VY, Picard M, Broutin I.
    New OprM structure highlighting the nature of the N-terminal anchor.
    Remerciements dans Front Microbiol. 2015 Jul 1 ;6:667. doi : 10.3389/fmicb.2015.00667

     

    • Toubiana J, Rossi AL, Belaidouni N, Grimaldi D, Pene F, Chafey P, Comba B, Camoin L, Bismuth G, Claessens YE, Mira JP, Chiche JD.
    Src-family-tyrosine kinase Lyn is critical for TLR2-mediated NF-kappaB activation through the PI 3-kinase signaling pathway.
    Innate Immunity 2015 Jun 8. pii : 1753425915586075. doi: 10.1177/1753425915586075. 2D DIGE

     

    • Hyzewicz J, Tanihata J, Kuraoka M, Ito N, Miyagoe-Suzuki Y, Takeda S.
    Low intensity training of mdx mice reduces carbonylation and increases expression levels of proteins involved in energy metabolism and muscle contraction.
    Remerciements dans Free Radical Biology and Medecine 2015, (82) p122-136 doi: 10.1016/j.freeradbiomed.2015.01.023. Electrophorèse 2D

     

    • Bardot C, Besse-Hoggan P, Carles L, Le Gall M, Clary G, Chafey P, Federici C, Broussard C, Batisson I.
    How the edaphic Bacillus megaterium strain Mes11 adapts its metabolism to the herbicide mesotrione pressure.
    Environmental Pollution Volume 199, April 2015, Pages 198–208, doi:10.1016/j.envpol.2015.01.0292D-DIGE et nLC-MALDI-TOF/TOF.


    • Colombat, S. Holifanjaniaina, S. Onifarasoaniaina, S. Valleix, H. Maisonneuve,J.E. Kahn, la plateforme protéomique de l’université Paris Descartes (3P5)*
    La protéomique, une nouvelle technique pour un typage optimal des amyloses
    Rev Med Interne. 2015 ;36(5):346-51 doi: 10.1016/j.revmed.2014.11.006 Identification de protéines responsables de pathologies cliniques à dépôts de protéines *Guillonneau F, Leduc M, Broussard C, Salnot V.


    • Vallabhaneni KC, Penfornis P, Dhule S, Guillonneau F, Adams KV, Mo YY, Xu R, Liu Y, Watabe K, Vemuri MC, Pochampally R.
    Extracellular vesicles from bone marrow mesenchymal stem/stromal cells transport tumor regulatory microRNA, proteins, and metabolites.
    Oncotarget 2015 6(7):4953-67 doi : 10.18632/oncotarget.3211 extracellular vesicles analysis

     

    • Kanold J, Immel F, Broussard C, Guichard N, Plasseraud L, Corneillat M, Alcaraz G, Brümmer F, Marin F.
    The test skeletal matrix of the black sea urchin Arbacia lixula.
    Comparative Biochemistry and Physiology Part D : Genomics and Proteomics. doi:10.1016/j.cbd.2014.12.002Identification de protéines.

     

    • Rogée S, Le Gall M, Chafey P, Bouquet J, Cordonnier N, Federici C, Pavio N.
    Quantitative proteomics identifies host factors modulated during acute hepatitis E infection in swine model
    J Virol. 2015 Jan 1 ;89(1):129-43  doi: 10.1128/JVI.02208-14 2D-DIGE.

     

    • Sohm B, Immel F, Bauda P, Pagnout C.
    Insight into the primary mode of action of TiO2 nanoparticles on Escherichia coli in the dark.
    Remerciements dans Proteomics. 2015 Jan ;15(1):98-113 doi: 10.1002/pmic.2014001012D-DIGE.

     

    2014

    • Boumaiza M1, Ezzine A, Jaouen M, Sari MA, Marzouki MN.
    Molecular characterization of a novel hepcidin (HepcD) from Camelus dromedarius. Synthetic peptide forms exhibit antibacterial activity.
    remerciements dans J Pept Sci. 2014 Sep ;20(9):680-8. doi : 10.1002/psc.2644analyse MALDI TOF

     

    • Benas, P., Auzeil, N., Legrand, L., Brachet, F., Regazzetti, A. & Ries-Kautt, M.
    Weak protein–cationic co-ion interactions addressed by X-ray crystallography and mass spectrometry
    Acta crystallographica. Section D, Biological crystallography (2014). 70, 2217-2231. doi: 10.1107/S1399004714011304. résolution de structure d’adduits lysozyme-cation

     

    • Gougelet A., Torre C., Veber P., Sartor C., Bachelot L., Denechaud P.D., Godard C., Moldes M., Burnol A.F. , Terris B., Guillonneau F., Ye T., Schwartz M., Braeuning A., Perret C., Colnot S.
    T-cell factor 4 and β-catenin chromatin occupancies pattern liver zonal metabolism
    Hepatology. 2014 Jun ;59(6):2344-57. doi: 10.1002/hep.26924. Analyses de partenaires de la beta catenin par nLC-MALDI-TOF/TOF

     

    • Loc’h J, Blaud M, Réty S, Lebaron S, Deschamps P, Bareille J, Jombart J, Robert-Paganin J, Delbos L, Chardon F, Zhang E, Charenton C, Tollervey D, Leulliot N.
    RNA mimicry by the fap7 adenylate kinase in ribosome biogenesis.
    remerciements dans PLoS Biol. 2014 May 13 ;12(5). doi: 10.1371/journal.pbio.1001860. Analyses in-gel de composition de préribosomes


    • Vidau C., Panek J., Texier C., Biron D., Belzunces L., Le Gall M., Broussard C., Delbac F., El Alaoui H.
    Differential proteomic analysis of midguts from Nosema ceranae-infected honeybees reveals manipulation of key host functions.
    J Invertebr Pathol. 2014 Sep ;121:89-96. doi: 10.1016/j.jip.2014.07.002. 2D-DIGE et MALDI-TOF/TOF

     

    • Régent A, Lofek S, Dib H, Bussone G, Tamas N, Federici C, Broussard C, Guillevin L, Mouthon L.
    Identification of target antigens of anti-endothelial cell antibodies in patients with anti-neutrophil cytoplasmic antibody-associated vasculitides : A proteomic approach.
    Clinical Immunology pii : S1521-6616(14)00084-9. doi: 10.1016/j.clim.2014.03.020. 2D-DIGE et MALDI-TOF/TOF


    • Mallat Y., Tritsch E., Ladouce R., Lorenz Winter D., Friguet B., Li Z., Mericskay M.
    « Proteome modulation in H9c2 cardiac cells by miR-378 and miR-378 ».
    Remerciements dans Mol Cell Proteomics. 2014 Jan ;13(1):18-29. doi: 10.1074/mcp.M113.030569. (2D-DIGE et MALDI-TOF/TOF).

     

    • Toumi H, Boumaizaa M, Immel F, Sohm B, Felten V, Férard JF.
    Effect of deltamethrin (pyrethroid insecticide) on two clones of Daphnia magna (Crustacea, Cladocera) : A proteomic investigation.
    Remerciements dans Aquatic Toxicology 148(2014)40-47doi: 10.1016/j.aquatox.2013.12.0222D-DIGE.

     

    2013

    • Bakala H., Ladouce R., Baraibar M.A., Friguet B.
    « Differential expression and glycative damage affect specific mitochondrial proteins with aging in rat liver ».
    Remerciements dans BBA Molecular Basis of Disease. 1832, 12, 2013, 2057–67 doi: 10.1016/j.bbadis.2013.07.0152D-DIGE et MALDI-TOF/TOF

     

    • Prévilon M, Le Gall M, Chafey P, Federici C, Pezet M, Clary G, Broussard C, Guillonneau F, Mercadier JJ, Rouet-Benzineb P.
    Comparative differential proteomic profiles of nonfailing and failing hearts after in vivo thoracic aortic constriction in mice overexpressing FKBP12.6.
    Physiol Rep. 2013 Aug ;1(3):e00039. doi : 10.1002/phy2.39(2D-DIGE)

     

    • Gwladys.I Bertin ; Thomas Lavstsen ; Francois Guillonneau ; Justin Doritchamou ; Christian.W Wang ; Jakob.S Jespersen ; Sem Ezimegnon ; Nadine Fievet ; Jules.M Alao ; francis Lalya ; Achille Massougbodji ; Nicaise Tuikue Ndam ; Thor.G Theander ; Philippe Deloron
    « Expression of the domain cassette 8 Plasmodium falciparum erythrocyte membrane protein 1 is associated with cerebral malaria in Benin »
    PLoS One. 2013 Jul 29 ;8(7):e68368. doi : 10.1371/journal.pone.0068368. Protéines membranaires, label-free quantification

     

    • Colombat, S. Holifanjaniaina, F. Guillonneau, H. Mal, S. Hirschi, M. Reynaud-Gaubert, M. Stern.
    Mass spectrometry-based proteomic analysis : a good diagnostic tool for cystic lung light chain deposition disease.
    Am J Respir Crit Care Med. 2013 Aug 1 ;188(3):404-5. doi : 10.1164/rccm.201301-0071LE. Identification de protéines responsables de pathologies cliniques à dépôts de protéines

     

    • Bertin G., Sabbagh A., Guillonneau F., Jafari-Guemouri S., Ezimegnon S., Federici C., Houkpatin B., Fievet N., Deloron P.
    « Differential protein expression profiles between Plasmodium falciparum parasites isolated from subjects presenting with pregnancy-associated malaria and uncomplicated malaria in Benin »
    J Infect Dis. (2013) doi : 10.1093/infdis/jit377. Protéines membranaires, label-free quantification, Bioanalyse

     

    • Firrincieli D, Zúñiga S, Rey C, Wendum D, Lasnier E, Rainteau D, Braescu T, Falguières T, Boissan M, Cadoret A, Housset C, Chignard N.
    Vitamin D nuclear receptor deficiency promotes cholestatic liver injury by disruption of biliary epithelial cell junctions in mice.
    remerciements dans Hepatology. 2013 doi : 10.1002/hep.26453. SDS PAGE-bands identifications by nLC-MALDI-TOF/TOF


    • Faure C, Morio B, Chafey P, Le Plénier S, Noirez P, Randrianarison-Huetz V, Cynober L, Aussel C, Moinard C.
    Citrulline enhances myofibrillar constituants expression of skeletal muscle and induces a switch in muscle energy metabolism in malnourished aged rats.
    Proteomics. 2013, 13, 2191-2201. doi : 10.1002/pmic.2012002622D-E

     

    • Daulat A, Maurice P, Jockers R.
    G Protein Coupled Receptors — Trafficking and Oligomerization Techniques for the Discovery of GPCR-Associated Protein Complexes
    Remerciements dans Methods in Enzymology, Volume 521, 2013, 329–345, doi: 10.1016/B978-0-12-391862-8.00018-1. Analyses de partenaires de complexes protéiques par nLC-MALDI-TOF/TOF

     

    • Nikolov I.G., Joki N., Galmiche A., Nguyen-Khoa T., Guerrera I.C., Guillonneau F., Ivanovski O., Phan O., Maizel J., Marçon F., Benchitrit J., Lucas A., Edelman A., Lacour B., Drüeke T.B., Massy Z.A.
    Farnesyltransferase inhibitor R115777 protects against vascular disease in uremic mice.
    Atherosclerosis 2013 Jul ;229(1):42-51. doi: 10.1016/j.atherosclerosis.2013.02.041Analyses de candidats issus de profiling sur billes par nLC-MALDI-TOF/TOF

     

    • PRIAM S., BOUGAULT C., HOUARD X., GOSSET M., SALVAT C., BERENBAUM F. and JACQUES C.
    Identification of soluble 14-3-3ε as a new subchondral bone mediator involved in cartilage degradation in osteoarthritis.
    Remerciements dans Arthritis & Rheumatism DOI 10.1002/art.37951. Analyse de secrétomes par iTRAQ par nLC-MALDI-TOF/TOF

     

    • D’allard D, Gay J, Descarpentries C, Frisan E, Adam K, Verdier F, Floquet C, Dubreuil P, Lacombe C, Fontenay M, Mayeux P, Kosmider O.
    « Tyrosine Kinase Inhibitors Induce Down-Regulation of c-Kit by Targeting the ATP Pocket. »
    PLoS One. 2013 Apr 23 ;8(4). doi: 10.1371/journal.pone.0060961. Analyse de phosphoprotéines par SILAC

     

    • Deracinois B, Pottiez G, Chafey P, Teerlink T, Camoin L, Broussard C, Couraud PO, Ceccheli R, Karamanos Y, Flahaut C.
    « Glial-cell-mediated re-induction of the blood-brain barrier phenotype in brain capillary endothelial cells : a differential gel electrophoresis study. »
    Proteomics. 2013 Apr ;13(7):1185-99. doi: 10.1002/pmic.201200166. 2D-DIGE et MALDI-TOF/TOF

     

    • Brégnard C, Zamborlini A, Leduc M, Chafey P, Camoin L, Saïb A, Benichou S, Danos O, Basmaciogullari S.
    « Comparative Proteomic Analysis of HIV-1 Particles Reveals a Role for Ezrin and EHD4 in the Nef-dependent Increase of Virus Infectivity. »
    J Virol. 2013 Apr ;87(7):3729-40. doi: 10.1128/JVI.02477-12. Analyses quantitatives par iTRAQ par nLC-MALDI-TOF/TOF

     

    • Beilstein F., Bouchoux J., Rousset M., Demignot S.
    Proteomic analysis of lipid droplets from Caco-2/TC7 enterocytes identifies novel modulators of lipid secretion.
    remerciements dans PLoS One. 2013 ;8(1):e53017. doi: 10.1371/journal.pone.0053017. Analyses quantitatives par iTRAQ et nLC-MALDI-TOF/TOF

     

    2009-2012

    2012

    • Lasonder E, Green JL, Camarda G, Talabani H, Holder AA, Langsley G, Alano P. The Plasmodium falciparum schizont phosphoproteome reveals extensive phosphatidylinositol and cAMP-protein kinase A signaling. doi: 10.1021/pr300557m. Remerciements dans J Proteome Res. 2012 Nov 2 ;11(11):5323-37 Analyse de résidu phosphorylés par une kinase parasitaire par nLC-MALDI-TOF/TOF

     

    • Huguet F, Melet A, Alves de Sousa R, Lieutaud A, Chevalier J, Maigre L, Deschamps P, Tomas A, Leulliot N, Pages JM, Artaud I.
    Hydroxamic acids as potent inhibitors of Fe(II) and Mn(II) E. coli methionine aminopeptidase : biological activities and X-ray structures of oxazole hydroxamate-EcMetAP-Mn complexes.
    ChemMedChem. 2012 Jun ;7(6):1020-30. doi : 10.1002/cmdc.201200076Analyse masse entière de l’aminopeptidase purifiée chez E. coli par ESI LTQ orbitrap

     

    • Dechavanne C, Guillonneau F, Chiappetta G, Sago L, Lévy P, Salnot V, Guitard E, Ehrenmann F, Broussard CChafey P, Le Port A, Vinh J, Mayeux P, Dugoujon JM, Lefranc MP, Migot-Nabias F. Mass Spectrometry Detection of G3m and IGHG3 Alleles and Follow-Up of Differential Mother and Neonate IgG3. PLoS One. 2012 ;7(9):e46097. doi: 10.1371/journal.pone.0046097. 1&2D-E, Label-free and immunoglobulin G variant analysis par nLC-MALDI-TOF/TOF

     

    • Le Grand F, Grifone R, Mourikis P, Houbron C, Gigaud C, Pujol J, Maillet M, Pagès G, Rudnicki M, Tajbakhsh S, Maire P. Six1 regulates stem cell repair potential and self-renewal during skeletal muscle regeneration. Remerciements dans J Cell Biol. 2012 Sep 3 ;198(5):815-32. doi: 10.1083/jcb.201201050. analyses nanopro

     

    • Hechler B, Ohlmann P, Chafey P, Ravanat C, Eckly A, Maurer E, Mangin P, Isola H, Cazenave JP, Gachet C. Preserved functional and biochemical characteristics of platelet components prepared with amotosalen and ultraviolet A for pathogen inactivationTransfusion. 2012 Oct 15. doi: 10.1111/j.1537-2995.2012.03923.x. 2D-DIGE

     

    • Dib H, Chafey P, Clary G, Federici C, Le Gall M, Dwyer J, Gavard J, Tamas N, Bussone G, Broussard C, Camoin L, Witko-Sarsat V, Tamby M, Mouthon L. Proteomes of umbilical vein and microvascular endothelial cells reflect distinct biological properties and influence immune recognitionProteomics 2012, Volume 12, Issue 15-16, pages 2547–2555. doi: 10.1002/pmic.201200060. 2D-DIGE, Bioanalyse

     

    • Valleix S., Gillmore J.D., Bridoux F., et coll. Hereditary systemic amyloidosis due to Asp76Asn variant β2-microglobulinRemerciements dans N Engl J Med. 2012 Jun 14 ;366(24):2276-83. doi: 10.1056/NEJMoa1201356. Identification de protéines responsables de pathologies cliniques à dépôts de protéines par nLC-MALDI-TOF/TOF

     

    • Buet D., Gallais I., Lauret E., Denis N., Lombard B., Guillonneau F., Kosmider O., Loew D., Dusanter-Fourt I., Guillouf C., Mayeux P., Moreau-Gachelin F. Cotargeting signaling pathways driving survival and cell cycle circumvents resistance to Kit inhibitors in leukemiaBlood. 2012 May 3 ;119(18):4228-41. doi: 10.1182/blood-2011-07-368316. analyses de phosphopeptides par nLC-MALDI-TOF/TOF

     

    • Davalieva K., Kiprijanovska S., Broussard C., Petrusevska G., Efremov G. Proteomic Analysis of Infiltrating Ductal Carcinoma Tissues by Coupled 2D DIGE/MS/MS Analysis. Molecular Biology, 2012, Vol. 46, No. 3, pp. 421–432. 2D-spots identifications par MALDI-TOF/TOF

     

    • Davalieva K., Kiprijanovska S., Noveski P., Plaseski T., Kocevska B., Broussard C., Plaseska-Karanfilska D. Proteomic analysis of seminal plasma in men with different spermatogenic impairmentAndrologia. 2012 Aug ;44(4):256-64. doi: 10.1111/j.1439-0272.2012.01275.x. 2D-spots identifications par MALDI-TOF/TOF

     

    • Davalieva K., Kiprijanovska S., Noveski P., Plaseski T., Kocevska B., Plaseska-Karanfilska D. « Human seminal plasma study : a search for male infertility biomarkers »Remerciements dans Balkan Journal of Medical Genetics. Supplement 15 (2012) 35-38. doi: 10.2478/v10034-012-0016-92D-spots identifications par MALDI-TOF/TOF

     

    • Luissint AC, Federici C, Guillonneau F, Chrétien F, Camoin L, Glacial F, Ganeshamoorthy K, Couraud PO. Guanine nucleotide-binding protein Gαi2 : a new partner of claudin-5 that regulates tight junction integrity in human brain endothelial cellsJ Cereb Blood Flow Metab. 2012 May ;32(5):860-73. doi: 10.1038/jcbfm.2011.202. Identification de composants de complexes protéiques par nLC MALDI-TOF/TOF, Bioanalyse

     

    • Thirant C., Galan-Moya EM., Dubois LG., Pinte S, Chafey P., Broussard C., Varlet P., Devaux B., Soncin F., Gavard J., Junier MP., Chneiweiss H. Differential proteomic analysis of human glioblastoma and neural stem cells reveals HDGF as a novel angiogenic secreted factorStem Cells. 2012 May ;30(5):845-53. doi: 10.1002/stem.1062. 2D-DIGE et MALDI-TOF/TOF

     

    • Haste NM, Talabani H, Doo A, Merckx A, Langsley G, Taylor SS. Exploring the Plasmodium falciparum cyclic-adenosine monophosphate (cAMP)-dependent protein kinase (PfPKA) as a therapeutic targetRemerciements dans Microbes Infect. 2012 Aug ;14(10):838-50. doi: 10.1016/j.micinf.2012.05.004Analyse de résidu phosphorylés par une kinase parasitaire par nLC MALDI-TOF/TOF

     

    • Bussone, G., Tamby, M., Calzas, C., Kherbeck, N., Sahbatou, Y., Sanson, C., Ghazal, K., Dib, H., Weksler, B., Broussard C, Verrecchia, F., Yaici, A., Witko-Sarsat, V., Simonneau, G., Guillevin, L., Humbert, M., Mouthon, L. IgG from patients with pulmonary arterial hypertension and/or systemic sclerosis bind to vascular smooth muscle cell and induce cell contractionAnnals of the Rheumatic Diseases 2012 71:596-605. doi: 10.1136/annrheumdis-2011-200195. 2D-spots identification par MALDI-TOF/TOF

     

    • Choucha-Snouber L, Letourneur F, Chafey P, Broussard C, Monge M, Legallais C, Leclerc E. Analysis of transcriptomic and proteomic profiles demonstrates the improvement of the MDCK cell function in a renal microfluidic biochipBiotechnol Prog. 2012 Mar-Apr ;28(2):474-84. doi: 10.1002/btpr.743. 2D-DIGE et MALDI-TOF/TOF


    • Dib, H., Tamby, M., Bussone, G., Regent, A., Berezné, A., Lafine, C., Simonneau, G., Broussard C, Guillevin, L., Witko-Sarsat, V., Humbert, M., Mouthon, L. Targets of anti-endothelial cell antibodies in pulmonary hypertension and sclerodermaEuropean Respiratory Journal 2012. doi: 10.1183/09031936.00181410. 2D-spots identification par MALDI-TOF/TOF

     

    • Khemtemourian, L., Desbenoit, Nicolas., Mahesh, P., Chatterjee, Sunanda., Deschemin, J-C., Vaulont, S., Tomas, A., Sari, M-A., Artaud, I.
    Synthesis and Biological Activity of Mouse Hepcidin Peptide Analogs Containing Three Disulfide Bridges : Manual and Microwave-Assisted Solid-Phase Peptide Synthesis.
    Remerciements dans Protein and Peptide Letters. Volume 19, Number 2, February 2012 , pp. 219-227(9). MALDI MS hepcidin mass measurements

     

    2011

    • Brezar V, Culina S, Østerbye T, Guillonneau F, Chiappetta G, Verdier Y, Vinh J, Wong FS, Buus S, Mallone R. T cells recognizing a peptide contaminant undetectable by mass spectrometry. PLOS One. 2011 ;6(12). doi: 10.1371/journal.pone.0028866. séparation, concentration et identification de peptides contaminants par nLC MALDI-TOF/TOF

     

    • Toubiana J, Rossi AL, Grimaldi D, Belaidouni N, Chafey P, Clary G, Courtine E, Pene F, Mira JP, Claessens YE, Chiche JD. IMPDHII protein inhibits Toll-like receptor 2-mediated activation of NF-kappaB. J Biol Chem. 2011 Jul 1 ;286(26):23319-33. doi: 10.1074/jbc.M110.201210. 2D-DIGE et MALDI-TOF/TOF

     

    • Thirant, C., Varlet, P., Lipecka, J., Le Gall, M., Broussard C, Chafey, P., Studler, JM., Lacombe, J., Lions, S., Guillaudeau, A., Camoin, L., Daumas-Duport, C., Junier, MP., Chneiweiss, H.
    Proteomic Analysis of Oligodendrogliomas Expressing a Mutant Isocitrate Dehydrogenase 1.
    Proteomics 2011 Nov ;11(21):4139-54. doi : 10.1002/pmic.201000646. 2D-DIGE et MALDI-TOF/TOF

     

    • Regent, A., Dib, H., Ly, KH., Agard, C., Tamby, MC., Tamas, N., Weksler, B., Federici, C.Broussard C, Guillevin, L., Mouthon L. Identification of target antigens of anti-endothelial-cell and anti-vascular-smooth-muscle-cell antibodies in patients with giant cell arteritis : a proteomic approachArthritis Research & Therapy 2011, 13:R107. doi: 10.1186/ar3388. 2D-spots identification par MALDI-TOF/TOF, Bioanalyse

     

    • Prot JM, Briffaut AS, Letourneur F, Chafey P, Merlier F, Grandvalet Y, Legallais C, Leclerc E. Integrated proteomic and transcriptomic investigation of the acetaminophen toxicity in liver microfluidic biochipPLoS One. 2011 ;6(8):e21268. doi : 10.1371/journal.pone.0021268. 2D-DIGE et MALDI-TOF/TOF

     

    • Bussone, G., Dib, H., Tamby, M., Broussard C, Federici, C., Woimant, G., Camoin, L., Guillevin, L., Mouthon, L. Identification of new autoantibody specificities directed at proteins involved in the transforming growth factor beta pathway in patients with systemic sclerosis. Arthritis Research & Therapy 2011, 13:R74. doi: 10.1186/ar3336. 2D-spots identification, Bioanalyse

     

    • Kahn JE, Dutoit-Lefevre V, Duban-Deweer S, Chafey P, Pottiez G, Lefranc D, Fain O, Cordier JF, Hatron PY, Bletry O, Prin L. Comparative proteomic analysis of blood eosinophils reveals redox signaling modifications in patients with FIP1L1-PDGFRA-associated chronic eosinophilic leukemiaJ Proteome Res. 2011 Apr 1 ;10(4):1468-80. doi: 10.1021/pr100836p. 2D-DIGE et MALDI-TOF/TOF

     

    2010

    • Morales MA, Watanabe R, Dacher M, Chafey P, Osorio y Fortéa J, Scott DA, Beverley SM, Ommen G, Clos J, Hem S, Lenormand P, Rousselle JC, Namane A, Späth GF. Phosphoproteome dynamics reveal heat-shock protein complexes specific to the Leishmania donovani infectious stageProc Natl Acad Sci U S A. 2010 May 4 ;107(18):8381-6. doi: 10.1073/pnas.0914768107. 2D-DIGE

     

    • Auger, J., Eustache, F., Maceiras, P., Broussard C, Chafey, P., Lesaffre, C., Vaiman, D., Camoin, L., Auer, J. Modified expression of several sperm proteins after chronic exposure to the antiandrogenic compound vinclozolin. Toxicol Sci 2010 ; 117(2):475-84. doi: 10.1093/toxsci/kfq199. 2D-DIGE et MALDI-TOF/TOF

     

    • Terrier, B., Tamby, M., Camoin, L., Guilpain, P., Bérezné, A., Tamas, N., Broussard C, Hotellier, F., Humbert, M., Simonneau, G., Guillevin, L., Mouthon, L. Antifibroblast antibodies from systemic sclerosis patients bind to α-enolase and are associated with interstitial lung diseaseAnn Rheum Dis 2010 ;69:428-433. doi: 10.1136/ard.2008.104299. 2D-spots identification par MALDI-TOF

     

    • Auer, J., Camoin, L., Guillonneau, F., Rigourd, V., Chelbi, S. T., Leduc, M., Laparre, J., Mignot, T. M., Vaiman, D. (2010). Serum profile in preeclampsia and intra-uterine growth restriction revealed by iTRAQ technology. J Proteomics 2010 ; 73(5):1004-1017. doi: 10.1016/j.jprot.2009.12.014. Analyses quantitatives par iTRAQ par nLC MALDI-TOF/TOF

     

    2009

    • Bellon S, Buchmann W, Gonnet F, Jarroux N, Anger-Leroy M, Guillonneau F, Daniel R. Hyphenation of surface plasmon resonance imaging to matrix-assisted laser desorption ionization mass spectrometry by on-chip mass spectrometry and tandem mass spectrometry analysis. Anal Chem. 2009 Sep 15 ;81(18):7695-702. doi: 10.1021/ac901140m. Analyses MALDI MS/MS de protéines immobilisées sur chip SPR.

     

    • Bussone, G., Dib, H., Dimitrov, J. D., Camoin, L., Broussard C, Tamas, N., Guillevin, L., Kaveri, S. V., and Mouthon, L. (2009). Identification of target antigens of self-reactive IgG in intravenous immunoglobulin preparations. Proteomics 2009, 9, 2253–2262. doi: 10.1002/pmic.200800819. 2D-spots identification

     

    • Tyagi, T. K., Ponnan, P., Singh, P., Bansal, S., Batra, A., Collin, F., Guillonneau, F., Jore, D., Patkar, S. A., Saxena, R. K., Parmar, V. S., Rastogi, R. C., Raj, H. G. (2009). Moonlighting protein in Starkeyomyces koorchalomoides : characterization of dihydrolipoamide dehydrogenase as a protein acetyltransferase utilizing acetoxycoumarin as the acetyl group donor. Biochimie 2009 ; 91(7):868-75. doi: 10.1016/j.biochi.2009.04.007. Analyse par nLC MALDI-TOF/TOF d’acetylation de protéines

     

    • Chafey, P., Finzi, L., Boisgard, R., Cauzac, M., Clary, G., Broussard C, Pegorier, J. P., Guillonneau, F., Mayeux, P., Camoin, L., Tavitian, B., Colnot, S., Perret, C. (2009). Proteomic analysis of beta-catenin activation in mouse liver by DIGE analysis identifies glucose metabolism as a new target of the Wnt pathway. Proteomics 2009 ; 9(15):3889-3900. doi: 10.1002/pmic.200800609. 2D-DIGE et MALDI-TOF/TOF

     

    • Maurice, P., Daulat, A. M., Broussard C, Mozo, J., Clary, G., Hotellier, F., Chafey, P., Guillaume, J. L., Ferry, G., Boutin, J. A., Delagrange, P., Camoin, L., and Jockers, R. (2008). A generic approach for the purification of signaling complexes that specifically interact with the carboxyl-terminal domain of G protein-coupled receptors. Mol Cell Proteomics 7, 1556-1569. doi: 10.1074/mcp.M700435-MCP200. 2D-E pour l’analyse nLC MALDI-TOF/TOF de complexes protéiques

     

    • Servettaz, A., Guilpain, P., Camoin, L., Mayeux, P.Broussard C, Tamby, M. C., Tamas, N., Kaveri, S. V., Guillevin, L., and Mouthon, L. (2008b). Identification of target antigens of antiendothelial cell antibodies in healthy individuals : A proteomic approach. Proteomics 8, 1000-1008. doi: 10.1002/pmic.200700794. 2D-spots identification par MALDI TOF

     

    • Terrier, B., Tamby, M. C., Camoin, L., Guilpain, P., Broussard C, Bussone, G., Yaici, A., Hotellier, F., Simonneau, G., Guillevin, L., Humbert, M., and Mouthon, L. (2008). Identification of target antigens of antifibroblast antibodies in pulmonary arterial hypertensionAm J Respir Crit Care Med 177, 1128-1134. doi: 10.1164/rccm.200707-1015OC. 2D-spots identification par MALDI TOF

     

    • Guilpain, P., Servettaz, A., Tamby, M. C., Chanseaud, Y., Tamas, N., Garcia de la Pena-Lefebvre, P., Broussard, C., Guillevin, L., Camoin, L., and Mouthon, L. (2007). A combined SDS-PAGE and proteomics approach to identify target autoantigens in healthy individuals and patients with autoimmune diseases. Ann N Y Acad Sci 1109, 538-549. 2D-spots identification par MALDI TOF

     

    • Daulat, A. M., Maurice, P., Froment, C., Guillaume, J. L., Broussard, C., Monsarrat, B., Delagrange, P., and Jockers, R. (2007). Purification and identification of G protein-coupled receptor protein complexes under native conditions. Mol Cell Proteomics 6, 835-844. 2D-E pour l’analyse de complexes protéiques