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    Guidance of vascular patterning


    SÉMINAIRE DE L'INSTITUT COCHIN

    Anne Eichmann

     Anne Eichmann
    Inserm U970, PARCC, Paris

     

    Jeudi 26 mai 2016 à 12h00

     invitée par Pierre-Olivier Couraud

     

    Institut Cochin, 22 rue Méchain, 75014 Paris
    Salle de conférence Rosalind Franklin, 2e étage

     

    Anne Eichmann’s lab studies the cellular and molecular mechanisms that direct formation of branched vascular networks. Blood vessels networks are of considerable size but develop in a highly stereotyped fashion and ramify together peripheral nerves. Prof. Eichmann has shown that vessels and nerves use shared cellular and molecular principles to orchestrate the formation of their branched networks. At the cellular level, capillaries employ specialized motile tip cells to ensure their directional outgrowth. The Eichmann laboratory has shown that tip cells are selected by dynamic interplay between VEGF and Notch and BMP/TGFB signaling, with VEGF acting as a positive regulator, and Notch and BMP/TGFB receptors inhibiting tip cell formation. The concerted interplay between these molecules ensures that appropriate tip cell numbers leading new vessel branches are formed. Molecularly, the Eichmann lab has shown that common signaling pathways guide capillary tip cells and axonal growth cones, including Slits and their Robo1 and 2 receptors. Molecules regulating capillary patterning and guidance in development also operate during pathological angiogenesis and represent targets to manipulate vessel growth in cancer, ocular and cardiovascular diseases.


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