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    TCR nanoscale organisation and antigen encounter by T and B lymphocytes

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    SÉMINAIRE DE L'INSTITUT COCHIN

    Balbino Alarcon 

    Balbino Alarcon

    Molecular Biology Center (CBM), CSIC, Madrid, Spain

     

    Jeudi 15 mars 2018 à 12h00

     

     invité par Fatah Ouaaz & Florence Niedergang

     

    Institut Cochin, 22 rue Méchain, 75014 Paris
    Salle de conférence Rosalind Franklin, 2e étage

     

    Balbino Alarcon is an ERC laureate immunologist at the Cell biology and Immunology department of the Molecular Biology Center (CBM) Severo Ochoa in Madrid, affiliated to the Spanish National Research Council (CSIC), which is the largest public institution dedicated to research in Spain and the third largest in Europe. He is leader of the group  “Signal transduction through the T cell antigen receptor”.

    His research which combines both immunology and cell biology focuses for many years on the investigation of the nanoscale organization of the TCR and the intramolecular mechanisms that allow the transmission of signals from the ligand-binding subunits to the cytoplasmic tails of the signal transducing subunits in the TCR. Finally, he is studying the role TC21, a member of the RRas subfamily of GTPases, in physiological processes of T and B lymphocytes such as homeostatic control of the populations, formation of the immunological synapse, thymic selection, or germinal center formation. Strikingly, his recent findings highlighted that T and more recently B lymphocytes (unpublished data) do perform also “phagocytosis” upon encounter with antigen.

     

    Some publications:

    • Alcover A, Alarcón B, Di Bartolo V. (2018). Cell Biology of T Cell Receptor Expression and Regulation. Annu. Rev. Immunol  36, 85-107.
    • Calleja E, Alarcón B, Oeste CL. (2017). Studying the Dynamics of TCR Internalization at the Immune Synapse. Methods Mol Bio 1584, 89-99.
    • Borroto A, Reyes-Garau D……and Alarcon B. (2016). First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases. Sci Transl Med. 8, 370.
    •  Lanco R, Borroto A, Schamel W, Pereira P, Alarcon B. (2014). Conformational changes in the T cell receptor differentially determine T cell subset development in mice. Sci Signal. 7, 354.
    • Fernández-Arenas E, Calleja E, …..and Alarcón B. (2014). β-Arrestin-1 mediates the TCR-triggered re-routing of distal receptors to the immunological synapse by a PKC-mediated mechanism. EMBO J. 33, 559-77.
    • Schamel WW, Alarcón B. (2013). Organization of the resting TCR in nanoscale oligomers. Immunol Rev 251, 13-20.
    • Martínez-Martin, N., Fernández-Arenas, E., Cemerski, S., Delgado, P., Turner, M., Heuser, J., Irvine, D.J., Huang, B., Bustelo, X.R., Shaw, A.S., and Alarcón, B. (2011). TCR internalization from the immunological synapse mediated by TC21- and RhoG GTPase-dependent phagocytosis. Immunity 35, 208-222.
    • Kumar, R., Ferez, M., Swamy, M., Arechaga, I., Rejas, M., Valpuesta, J.M., Schamel, W.W.A., Alarcon, B., and van Santen, H.M. (2011). Increased sensitivity of antigen-experienced T cells via enrichment for oligomeric TCR complexes. Immunity 35, 375-387.

     

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