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    We are what we eat: modern stressors of the host-microbiota super-organism

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    Séminaire de l'Institut Cochin

    Jeudi 14 novembre 2019 - 12h00 - Salle de conférence Rosalind Franklin, 2ème étage

     

    Benoit Chassaing
    Benoit Chassaing

    Institut Cochin, département Endocrinologie, Métabolisme, Diabète (EMD), Paris

     

     invité par Pierre-Olivier Couraud et Sophie Vaulont

    Institut Cochin, 22 rue Méchain, 75014 Paris

     

    Résumé

    The intestinal tract is inhabited by a large and diverse community of microbes collectively referred to as the gut microbiota. While the gut microbiota provides important benefits to its host, disturbance of the microbiota–host relationship is associated with numerous chronic inflammatory diseases. We previously reported that, in mice, consumption of relatively low concentrations of commonly used emulsifiers, detergent-like molecules and ubiquitous component of processed foods, induced chronic colitis in susceptible host and low-grade inflammation and obesity/metabolic syndrome in wild-type hosts. Follow-up mechanistic studies demonstrated that the intestinal microbiota is the direct target of such additives, and importantly revealed that not all the microbiotas are impacted in the same way by such disturbance. Our ongoing work is revealing a central role played by mucus-penetrating microbiota in driving intestinal inflammation and metabolic abnormalities, opening new therapeutic avenues to treat and prevent chronic inflammatory disorders. 


     

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