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    Mucus-Penetrating Microbiota: Characterization, Mechanism and Therapeutic in Metabolic Diseases

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    Habilitation à Diriger des Recherches

     

    SOUTENANCE DE HDR DE L'INSTITUT COCHIN

     

    Benoit Chassaing

    Equipe Chassaing
    Département Endocrinologie, Métabolisme, Diabète (EMD)

     

    Lundi 16 décembre 2019 à 14h30

     

    Institut Cochin, 22 rue Méchain, 75014 Paris
    Salle de conférence Rosalind Franklin, 2e étage

    Résumé

    Humanity is facing an epidemic of metabolic disorders, and the increasing incidence of these complex disorders threatens to overwhelm the world’s health care systems and economies, making it a top public health priority in dire need of investigation. The intestinal tract is inhabited by a large and diverse community of bacteria, collectively referred to as the intestinal microbiota. When stably maintained at an appropriately safe distance from the epithelial cell monolayer, the microbiota provides important benefits to its host. However, disturbance of the microbiota-host relationship can alter intestinal homeostasis and drive chronic low-grade intestinal inflammation and associated metabolic abnormalities.
     
    We previously reported that a ubiquitous class of food additives, emulsifiers, detrimentally impact the microbiota resulting in its encroachment into the mucus layer that associated with development of low-grade inflammation and metabolic disorders. The central goal of our research is to investigate the hypothesis that bacteria that penetrate the inner part of the mucus layer, referred as invaders, promote development of metabolic alterations. We herein propose to identify mucus-invaders, in preclinical models and clinical conditions, and investigate mechanisms by which they promote inflammatory and metabolic abnormalities. Furthermore, we propose to define original approaches to modulate the intestinal microbiota in order to counteract microbiota encroachment and protect against associated metabolic abnormalities.

     

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