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    Signalome-wide assessment of host cell response to intracellular pathogens: a source of novel targets for anti-infectives



     Christian Doerig

    Christian Doerig

    Department of Microbiology, School of Biomedical Sciences
    MONASH UNIVERSITY, Victoria, Australia


    Mardi 30 janvier 2018 à 12h00


     invité par Pierre-Olivier Couraud


    Institut Cochin, 22 rue Méchain, 75014 Paris
    Salle de conférence Rosalind Franklin, 2e étage

    Prof Doerig will describe how his work on protein kinases of the kinome of the malaria parasite Plasmodium falciparum led his group to become interested in the signalling response of the host erythrocyte to infection.  An approach based on antibody microarrays allowed the identification of a number of host erythrocyte signalling pathways that are modulated by infection.  Subsequently, this approach was implemented with hepatocytes infected with Hepatitis C virus, leading to the identification of  a lead molecule for antiviral intervention, that targets a host kinase activated and required by the virus.  Finally, data obtained with the same approach, and that provide a mechanism that underlies the refractoriness to transmission of Dengue and Zika viruses of mosquitoes infected with the Wolbachia bacterial  endosymbiont, will be presented.

    Christian Doerig obtained his PhD in molecular virology at the Swiss Institute for Experimental Cancer Research (ISREC) in Lausanne, Switzerland. After post-doctoral training in virology in the USA, he turned his attention to malaria, pioneered the study of protein phosphorylation in the human malaria parasite Plasmodium falciparum, and is now a recognised leader in this field.  He is "Directeur de Recherches" at the French biomedical research agency Inserm and Honorary Professor of the University of Glasgow, Scotland.  He established the first Inserm unit in the UK, at the Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, and subsequently in Switzerland at the Inserm-EPFL joint laboratory, Ecole Polytechnique Fédérale de Lausanne (EPFL).  In 2011, he joined Monash University as Head of the Department of Microbiology, a position he held until 2015. He is now a Professor of Microbiology at the same Department, where he pursues his research on the kinomics of malaria parasites.  A recently emerged research topic in his laboratory is the signaling response of host cells to intracellular pathogens, which at the moment covers work in Plasmodium-infected erythrocytes, as well as in Flavivirus and Wolbachia infections.


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