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    The dark side of fibroblasts force



     Vignjevic Danijela

     Danijela Vignjevic

    Institut Curie, Paris


    Jeudi 22 mars 2018 à 12h00


     invitée par Florence Niedergang


    Institut Cochin, 22 rue Méchain, 75014 Paris
    Salle de conférence Rosalind Franklin, 2e étage

    We are invested in role of tumor microenvironment, particularly of cancer-associated fibroblasts (CAFs), in invasive migration of cancer cells. We found that in the presence of primary colon CAFs, cancer cells invade the basement membrane in a protease-independent manner. Using live imaging and atomic force microscopy we found that CAFs use mechanical forces to remodel the basement membrane, leading to the formation of gaps through which cancer cells can migrate (Glentis et al, 2017). We also found that CAFs assemble fibronectin fibrils via integrin β3 that triggered invasion of cancer cells through the stroma (Atieh et al, 2017). Currently, we are investigating if specific organization of CAFs and the matrix they produce can stimulate invasion of cancer cells, their resistance to therapy and tumor relapse.


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