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    Next generation High-throughput sequencing to analyze E. coli K1 pathophysiology and reveal new therapeutic targets


    Séminaire de l'Institut Cochin

    Lundi 18 juin 2018 - 12h00 - Salle de conférence Rosalind Franklin, 2ème étage


    David Skurnik
    Professeur des Universités-Praticien Hospitalier

    Hôpital Necker-Enfants Malades, Département de Microbiologie
    Et Institut Necker Enfants Malades, INSERM U1151, Paris


     invité par Sandrine Bourdoulous

    Institut Cochin, 22 rue Méchain, 75014 Paris



    Neonatal bacterial meningitis continues to be a serious disease. Despite treatment with appropriate antibiotics, mortality rates over 10% still ensue and up to 30% of survivors exhibit neurological sequelae such as hearing and neurologic impairment and hydrocephalus. In developed countries, E. coli is the leading cause of meningitis in premature neonates and the second cause, after group B streptococci in term neonates. Despite the use of advanced antibiotics, the morbidity and mortality rates associated with E. coli K1 meningitis remain unchanged over the last few decades. In this seminar, David will present an approach aiming to comprehensively evaluate (i) the virulence factors of E. coli K1 in neonatal meningitis and (ii) the antigens synthesized by this pathogen that can be targeted by immunotherapy.

    David Skurnick is has a long standing experience on bacterial sepsis in medicine, clinical microbiology, immunology and vaccinology. As a resident in medicine and clinical microbiology in Paris, he was involved in the clinical and microbiological diagnosis and management of bacterial infections and sepsis and the emergence and dissemination of antibiotic resistance. During his PhD thesis he examined numerous aspects of these two fields. He then moved to Harvard Medical School and Brigham and Women’s Hospital, first as a Research Fellow (2007) and then as an Instructor (2010) and an Assistant Professor of medicine (2012). Now he has a dual affiliation between Paris (Full Professor, Necker Hospital, University Paris Descartes) and Boston (Lecturer of Medicine, Harvard Medical School)

    His two current main field of interest are:

    • Antibiotic resistance: from a better control of antibiotic prescription to the link between antibiotic resistance and bacterial virulence
      Bacterial meningitis in neonates: virulence factors involved in bacterial pathophysiology, particularly in Escherichia coli K1: from the colonization of the gastro-
    • intestinal tract to the systemic dissemination and the crossing of the blood brain barrier. Development of new approaches to prevent and treat severe sepsis in neonates caused by E. coli K1, in particular, development of a multivalent vaccine.


    Quelques publications


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