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    Alternative splicing plays a key role in beta cell survival and function



    Delcio L.Eizirik 

    Decio L. Eizirik

    ULB Center for Diabetes Research, Medical Faculty, Universite Libre de Bruxelles, Belgique


    Jeudi 26 octobre 2017 à 12h00


     invité par Roberto Mallone


    Institut Cochin, 22 rue Méchain, 75014 Paris
    Salle de conférence Rosalind Franklin, 2e étage


    Alternative splicing (AS) is a complex posttranscriptional mechanism regulating gene expression. It regulates the inclusion/exclusion of exons into mature mRNAs, allowing individual genes to produce multiple protein isoforms that expand the proteome diversity. Functionally related transcript populations are coordinately spliced by master splicing factors that define regulatory networks. These networks allow cells to adapt their transcriptome in response to intra and extracellular cues. There is a growing interest in the role of AS in human diseases, but little is known regarding its role in type 1 diabetes. In the lecture I will discuss our recent findings suggesting that splicing events occurring in pancreatic beta cells regulate their function and survival, and the similarities between splicing regulation in brain and beta cells. Furthermore, identification of unique human islet splicing variants are allowing the identification of novel beta cell autoantigens and of biomarkers for in vivo beta cell imaging.

    Unveiling the role of AS in beta cell function and death will increase our understanding of diabetes pathogenesis and may open new avenues for disease prevention and therapy.

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