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    Tunneling Nanotubes, a Novel Mode of Macrophage -Tumor Cell Communication in Tumor Cell Invasion

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    SÉMINAIRE DE L'INSTITUT COCHIN

    Dianne Cox 

    Dianne Cox

    Albert Einstein College of Medicine, New York, USA

     

    Mercredi 20 septembre 2017 à 12h00

     

     invitée par Florence Niedergang

     

    Institut Cochin, Faculté de Médecine, 24 rue du Fbg St-Jacques, 75014 Paris
    Salle Schapira (2017), 2e étage

    Macrophage Phagocytosis and Motility in Health and Disease
    Macrophages play important roles in host defense against invading micro-organisms and they are also key players in initiating and maintaining an immune response. However, macrophages can also play negative roles, such as in chronic inflammatory disease. Also, tumor-associated macrophages (TAMs), which are present in large numbers in many tumors, appear to play an important role in promoting the progression of solid tumors to an invasive, metastatic phenotype. Macrophages are therefore a prime target for therapies, but it is important to elucidate the mechanisms by which they are recruited to and activated in tissues. The current research focus in the lab is on leukocyte signaling and the cytoskeleton as it bears on macrophage function such as phagocytosis, migration and cell – cell communication. The lab is also actively involved in the development of novel probes to monitor the regulation of actin dynamics in living cells including developing photoactivatable, photoconvertible probes and fluorescent biosensors.

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