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    Mechanics of blastocyst morphogenesis

    Webinaire de l'Institut Cochin

    Jeudi 6 janvier 2022 - 12h00 - Pour obtenir le lien d'accès Zoom, envoyez un mail à

     


    Jean-Léon MAITRE

    Unité "Genetics and developmental biology", Institut Curie, Paris

     

     invité par Catherine PATRAT

     

    Résumé

    During pre-implantation development, the mammalian embryo forms the blastocyst. The architecture of the blastocyst is essential to the specification of the first mammalian lineages and to the implantation of the embryo. Consisting of an epithelium enveloping a fluid-filled lumen and the inner cell mass, the blastocyst is sculpted by a succession of morphogenetic events. These deformations result from the changes in the forces and mechanical properties of the tissue composing the embryo. Combining microscopy, image analysis, biophysical tools and genetics, we study the mechanical and cellular changes leading to the formation of the blastocyst. In particular, we uncover the distinct mechanical strategies adopted by human and mouse embryos to become compacted and how spindle instabilities can trigger cell fragmentation.