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    Mechanical feedbacks in embryonic self-organization

    Webinaire de l'Institut Cochin

    Jeudi 20 mai 2021 - 12h00 - Pour obtenir le lien d'accès Zoom, envoyez un mail à


    Jérôme Gros

    Department of Developmental and Stem Cell Biology, Institut Pasteur, Paris


     invité par Pascal Maire




    I will present recent results we have obtained  on the role of tissue mechanics in two self-organized systems : gastrulation in avians and digit formation in mouse. In both cases we characterize the underlying  tissue mechanics and describe how mechanical forces feedback on gene expression to promote the self-organization of cell fate. Our findings demonstrate a central role for mechanical forces not only  in the shaping but also in the patterning of embryonic tissues.