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    Neurotransmitter GPCR signaling and Aging

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    SÉMINAIRE DE L'INSTITUT COCHIN

    Jianfeng Liu 

    Jianfeng Liu

    Professor, Deputy Dean College of Life Science and Technology,
    Huazhong University of Science and technology, Wuhan, China

     

    Mardi 14 novembre 2017 à 14h00

     

     invité par Ralf Jockers

     

    Institut Cochin, 22 rue Méchain, 75014 Paris
    Salle de conférence Rosalind Franklin, 2e étage

    Liu lab investigates some of the fundamental questions of class C GPCRs: What is the dynamic relationship between their structure and function, how the signals are transmitted from the membrane protein to the downstream effectors, and what is the final physiological and pharmacological role? He also studied how the important membrane proteins in sensory system modulate aging, longevity and metabolism.

    Dr. Liu joined the Huazhong University of Science and Technology (HUST) since 2002 with a full professor appointment in the College of Life Sciences and Technology. Currently, Dr. Liu is the Deputy Dean of the College of Life Sciences and Technology. He also serves as the Deputy Director in the Key Laboratory of Molecular Biophysics, the Ministry of Education. Dr. Liu has received the “Chang Jiang Scholars” award from the Ministry of Education. He also received the National Science Fund for Distinguished Young Scholars. Currently, Dr. Liu is the Editorial Board Member for the journal “Biophysics Reports”.

     

    Selected Publications: (*: correspondence author)

    1. Gong J, Yuan Y, Ward A, Kang L, Zhang B, Wu Z, Peng J, Feng Z, *Liu J, *Xu XZ.  The C. elegans taste receptor homolog LITE-1 is a photoreceptor. Cell., 2016, 167(5):1252-1263.
    2. Li G, Gong J, Lei H, *Liu J, *Xu XZ.  Promotion of behavior and neuronal function by reactive oxygen species in C. elegans. Nature Communications. , 2016, 7:13234.
    3. Chun L, Gong J, Yuan F, Zhang B, Liu H, Zheng T, Yu T, *Xu XZ, *Liu J.  Metabotropic GABA signalling modulates longevity in C. elegans. Nature Communications.,2015, 6: 8828.    
    4. Xue L, Rovira X, Scholler P, Zhao H, *Liu J, *Pin JP, Rondard P. Major ligand-induced rearrangement of the heptahelical domain interface in a G protein-coupled receptor dimer. Nature Chemical Biology., 2015, 11(2):134-40.
    5. Xu F, Zhao H, Feng X, Chen L, Chen D, Zhang Y, *Nan F, *Liu J, *Liu B. Single-Cell Chemical Proteomics with an Activity-Based Probe: Identification of Low-Copy Membrane Proteins on Primary Neurons. Angew Chem Int Ed Engl., 2014, 53(26):6730-3.

     

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