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    Epigenetic Targets in Cancer

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    SÉMINAIRE DE L'INSTITUT COCHIN

    Kristian Helin 

    Kristian Helin

    Biotech Research & Innovation Centre (BRIC), University of Copenhagen, Denmark

     

    Jeudi 14 décembre 2017 à 12h00

     

     invité par Valentina Boeva

     

    Institut Cochin, 22 rue Méchain, 75014 Paris
    Salle de conférence Rosalind Franklin, 2e étage

    Cell fate decisions are regulated by an intricate interplay between the cellular environment, growth factors and intracellular signaling pathways. The balance of stability versus plasticity in stem cells is a regulatory challenge, and extensive studies in recent years have focused on understanding the contribution of transcription factors and chromatin-associated proteins in the regulation of cellular identity and differentiation pathways. The crucial role of chromatin-associated proteins in maintaining normal homeostasis has been illustrated by next generation sequencing projects, which frequently have identified somatic mutations in genes coding for members of this group of proteins.

    Our research is focused on understanding the role of chromatin-associated proteins in maintaining cellular identity and how their deregulation leads to cancer. As part of this effort, we have generated a number of mouse models for glioma and leukemia that we are using to identify chromatin-associated proteins as targets for the development of anti-cancer therapy. In the seminar, I will present an update on our efforts to understand how chromatin-associated proteins can influence transcription, differentiation and contribute to the development of cancer.

     

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