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    The Interdependence of Systemic and Cellular Immunometabolism


    Séminaire de l'Institut Cochin

    Jeudi 27 septembre 2018 - 12h00 - Salle de conférence Rosalind Franklin, 2ème étage


    Lydia Lynch

    Trinity Biomedical Sciences Institute, Dublin, Ireland


     invitée par Agnès Lehuen

    Institut Cochin, 22 rue Méchain, 75014 Paris



     It is now well accepted that obesity causes immune dysregulation, but many studies have so far focused on increased inflammation that interferes with insulin signaling and ultimately contributes to type 2 diabetes. Our findings show that in addition to increased inflammation, obesity also impairs immune surveillance by cytotoxic lymphocytes.  I will discuss our study which highlights the interdependence of cellular and systemic metabolism in immune regulation Our results demonstrate that the lipotoxic obese environment impairs immune surveillance through altering normal metabolic processes, which suggests that metabolic reprogramming of NK cells may improve cancer and infection outcomes in obesity. The realization that metabolism controls cell function in health and disease has led to a resurgent interest in cellular metabolism, with the ultimate goal of targeting metabolism therapeutically. The metabolic state of the organism affects the immune system through altered fuel supplies and cellular metabolism used by immune cells. This in turn regulates immune cell function, which we now know can subsequently regulate whole body metabolism, such that an immunometabolic loop exists between systemic and cellular metabolism in the organism.


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