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    The enteric nervous system in gut and brain health and diseases

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    Séminaire de l'Institut Cochin

    Jeudi 20 juin 2019 - 12h00 - Salle de conférence Rosalind Franklin, 2ème étage

     


    Michel Neunlist

    Inserm TENS - U1235, Institut des Maladies de l’Appareil Digestif,
    Université de Nantes

     

     invité par Benoit Viollet

    Institut Cochin, 22 rue Méchain, 75014 Paris

     

    Résumé

     The enteric nervous system (ENS), our second brain, is increasingly recognized to play a central role in a wide array of gut functions (motility-intestinal epithelial barrier-immune). In addition, remodeling of the ENS is thought to be directly involved in the gut diseases or in gut dysfunctions observed in central nervous system. In this context, the talk will be organized into three main parts. The first part will describe the anatomical and functional basis of the control of major gut functions by the ENS and its regulation by environmental factors such as the gut microbiota. It will next describe the remodeling and contribution of the ENS to chronic diseases of the gut (IBD – cancer) and brain (Parkinson). In the final part, it will present novel strategies aimed at targeting the ENS and restoring gut functions.

     

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