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    Adaptive Immune Response Variation and Suppression in Lyme Borreliosis

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    Séminaire de l'Institut Cochin

    Lundi 16 septembre 2019 - 12h00 - Salle de conférence Rosalind Franklin, 2ème étage

     

    Monica Embers
    Monica Embers

    Division of Bacteriology and Parasitology,
    Tulane National Primate Research Center,
    Tulane University Health Sciences,
    Covington, LA, USA

     

     invitée par Alain Trautmann

    Institut Cochin, 22 rue Méchain, 75014 Paris

     

    Résumé

    Impaired immune responses induced by Borreliae occur in reservoir and incidental hosts.  Persistence of Bb both in reservoir (murine) and incidental (primate) hosts is the norm and not the exception. The Lyme disease spirochete engages both in immune evasion and in active immune suppression. In particular, the ability of this pathogen to suppress humoral immunity and memory responses has been well-characterized in mice  [92-94]. We have performed an analysis of antibody responses to an unrelated vaccine antigen in primates infected with Borrelia. Our preliminary data  demonstrate that Borrelia infection can suppress acquired immune responses in a pathogen-independent fashion with variation in outbred hosts.

     

    Quelques publications

    • Caskey, J. R., et al. (2019). "The Functional and Molecular Effects of Doxycycline Treatment on Borrelia burgdorferi Phenotype." Front Microbiol 10: 690. https://www.frontiersin.org/articles/10.3389/fmicb.2019.00690/full
    • Embers, M. E., et al. (2017). "Variable manifestations, diverse seroreactivity and post-treatment persistence in non-human primates exposed to Borrelia burgdorferi by tick feeding." PLoS ONE 12(12): e0189071. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0189071
    • Crossland, N. A., et al. (2018). "Late Disseminated Lyme Disease: Associated Pathology and Spirochete Persistence Posttreatment in Rhesus Macaques." The American Journal of Pathology 188(3): 672-682. https://www.sciencedirect.com/science/article/pii/S0002944017308945?via%3Dihub

     

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