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    Mechanotransduction at at adherens junctions

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    SÉMINAIRE DE L'INSTITUT COCHIN

    René-Marc Mège 

    René-Marc Mège

    Institut Jacques Monod, Paris

     

    Jeudi 7 septembre 2017 à 12h00

     

     invité par Mireille Lambert

     

    Institut Cochin, 22 rue Méchain, 75014 Paris
    Salle de conférence Rosalind Franklin, 2e étage

    Mechanical constraints and force transmission play an essential role in multicellular living organisms, regulating basic biological processes such as morphogenesis, tumor metastasis and tissue repair. Cell adhesions, coupled to the contractile cytoskeleton, are major sites of force transmission in cells. This mechanical coupling which enables cells to sense, signal, and respond to physical changes in the environment, has however been largely understudied. Our research aims at understanding how cell adhesion-associated mechanotransduction and mechanosensing regulates cell behavior and tissue mechanics. In this context, we are studying the cooperation between adhesion, mechanical
    and biochemical signaling for the adaptation of living cells to changes in their physical environment at various scales, from single molecules to tissues. During the seminar, I will develop our last discoveries in the molecular mechanisms associated to mechanotransduction and mechanosensing at cadherin based adherens junctions. 

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