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    Novel tools to interrogate T cell recognition in cancer and autoimmunity

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    Séminaire de l'Institut Cochin

    Jeudi 24 janvier 2019 - 12h00 - Salle de conférence Rosalind Franklin, 2ème étage

     


    Sine Reker Hadrup

    Department of Health Technology, Technical University of Denmark

     

     invitée par Roberto Mallone
     invited by Roberto Mallone

    Institut Cochin, 22 rue Méchain, 75014 Paris

     

    Résumé

     S.R. Hadrup has pioneered the study of antigen-specific T-cell responses in different disease settings using high throughput technologies.

     

    Quelques publications

    • Bentzen AK et al. T cell receptor fingerprinting enables in-depth characterization of the interactions governing recognition of peptide-MHC
      complexes. Nat Biotechnol. 2018
    • Bentzen AK et al. Large-scale detection of antigen-specific T cells using peptide-MHC-I multimers labeled with DNA barcodes. Nat Biotechnol. 2016
    • Verdegaal EM et al. Neoantigen landscape dynamics during human melanoma-T cell interactions. Nature. 2016
    • McGranahan N et al. Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade. Science. 2016
    • Kvistborg P et al. Thinking outside the gate: single-cell assessments in multiple dimensions. Immunity. 2015
    • Frøsig TM et al. Broadening the repertoire of melanoma-associated T-cell epitopes. Cancer Immunol Immunother. 2015
    • Linnemann C et al. High-throughput identification of antigen-specific TCRs by TCR gene capture. Nat Med. 2013
    • Gilchuk P et al. Discovering naturally processed antigenic determinants that confer protective T cell immunity. J Clin Invest. 2013
    • Andersen RS et al. Parallel detection of antigen-specific T cell responses by combinatorial encoding of MHC multimers. Nat Protoc. 2012
    • Hadrup SR et al. Parallel detection of antigen-specific T-cell responses by multidimensional encoding of MHC multimers. Nat Methods. 2009

     

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