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    Fate and function of tumor extracellular vesicles in vivo


    Séminaire de l'Institut Cochin

    Jeudi 6 juin 2019 - 12h00 - Salle de conférence Rosalind Franklin, 2ème étage


    Vincent Hyenne

    Lab Tumor Biomechanics, Institut d’hématologie et d'immunologie, Strasbourg


     invité par Julie Chaumeil

    Institut Cochin, 22 rue Méchain, 75014 Paris



    Extracellular vesicles (EVs), including exosomes, have emerged as novel mediators of cell/cell communication in multiple biological and pathological contexts, in particular in tumor progression. They are produced by all cell types, present in every body fluid and contain proteins and RNA cargoes able to induce a phenotypic change in their receiving cell. Over the past years, we used different animal models to better understand the biogenesis, fate and function of EVs in vivo. Our work now focuses on the Ral GTPases (RalA and RalB in mammals), that we initially identified as novel regulators of exosomes secretion in C. elegans (Hyenne et al. JCB 2015). We further show that RalA and RalB control EVs secretion levels, content and function in mouse mammary carcinoma. Our recent data suggest that this is likely to directly impact metastasis formation (unpublished). In parallel, we developed the use of zebrafish as a novel animal model to track circulating EVs in a living organism at high temporal and spatial resolution (Hyenne et al. Dev. Cell 2019). We provided the first description of tumor EVs’ hemodynamic behavior and documented their intravascular arrest, uptake and fate in vivo. Finally, we demonstrated that tumor EVs activate macrophages and promote metastatic outgrowth.

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