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    M. tuberculosis infection of human macrophages in time and space

    Webinaire de l'Institut Cochin (département 3I)

    Lundi 17 mai 2021 - 12h00 - Pour obtenir le lien d'accès Zoom, envoyez un mail à

     


    Maximiliano G. Gutierrez

    The Francis Crick Institute, London, UK

     

     invité par Florence Niedergang


    Résumé

    Our research focuses on the fundamental molecular and cellular mechanisms that regulate the interactions between M. tuberculosis and host cells. We aim to dissect the host cell factors that contribute to M. tuberculosis control as well as the M. tuberculosis factors that this pathogen uses to highjack host cells. To this end, we use a variety of cutting-edge imaging approaches and model systems. In this seminar, I will present some recent data from our group regarding the environments where M. tuberculosis survives in human macrophages and the barriers that these environments represent for therapy.

     

    Quelques publications

    • Bernard, E.M., A. FEARNS, C. Bussi, P. Santucci, C.J. Peddie, R.J. Lai, L.M. Collinson, and M.G. GUTIERREZ. M. tuberculosis infection of human iPSC-derived macrophages reveals complex membrane dynamics during xenophagy evasion. J Cell Sci. (2020) 134.(5)
    • FEARNS, A., D.J. Greenwood, A. Rodgers, H. Jiang, and M.G. GUTIERREZ. Correlative light electron ion microscopy reveals in vivo localisation of bedaquiline in Mycobacterium tuberculosis-infected lungs. PLoS Biol. (2020) 18:e3000879.
    • Giraud-Gatineau, A., J.M. Coya, A. Maure, A. Biton, M. Thomson, E.M. Bernard, J. Marrec, M.G. GUTIERREZ, G. Larrouy-Maumus, R. Brosch, B. Gicquel, and L. Tailleux. The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection. Elife. (2020) 9.
    • Greenwood, D.J., M.S. Dos Santos, S. Huang, M.R.G. Russell, L.M. Collinson, J.I. MacRae, A. West, H. Jiang, and M.G. GUTIERREZ. Subcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages. Science. (2019) 364:1279-1282.
    • Hartlova, A., S. Herbst, J. Peltier, A. Rodgers, O. Bilkei-Gorzo, A. FEARNS, B.D. Dill, H. Lee, R. Flynn, S.A. Cowley, P. Davies, P.A. Lewis, I.G. Ganley, J. Martinez, D.R. Alessi, A.D. Reith, M. Trost, and M.G. GUTIERREZ. LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages. EMBO J. (2018) 37.
    • Lerner, T.R., S. Borel, D.J. Greenwood, U. Repnik, M.R. Russell, S. Herbst, M.L. Jones, L.M. Collinson, G. Griffiths, and M.G. GUTIERREZ. Mycobacterium tuberculosis replicates within necrotic human macrophages. J Cell Biol. (2017) 216:583-594.
    • Schnettger, L., A. Rodgers, U. Repnik, R.P. Lai, G. Pei, M. Verdoes, R.J. Wilkinson, D.B. Young, and M.G. GUTIERREZ. A Rab20-Dependent Membrane Trafficking Pathway Controls M. tuberculosis Replication by Regulating Phagosome Spaciousness and Integrity. Cell Host Microbe. (2017) 21:619-628 e615.