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    The impact of cell mechanics on organ-specific T cell responses




    Jens Stein

    Theodor Kocher Institute, University of Bern,


    Lundi 27 mars 2017 à 12h00

     invité par Jérôme Delon

    Institut Cochin, 22 rue Méchain, 75014 Paris
    Salle de conférence Rosalind Franklin, 2e étage


    Selected publications:

    Ozga AJ, Moalli F, Abe J, Swoger J, Sharpe J, Zehn D, Kreutzfeldt M, Merkler D, Ripoll J, Stein JV. pMHC affinity controls duration of CD8+ T cell-DC interactions and imprints timing of effector differentiation versus expansion. J Exp Med. 2016 Nov 14;213(12):2811-2829.

    Köchl R, Thelen F, Vanes L, Brazão TF, Fountain K, Xie J, Huang CL, Lyck R, Stein JV, Tybulewicz VL. WNK1 kinase balances T cell adhesion versus migration in vivo. Nat Immunol. 2016 Sep;17(9):1075-83.

    Stein JV. T Cell Motility as Modulator of Interactions with Dendritic Cells. Front Immunol. 2015 Nov 2;6:559.

    Moalli F, Proulx ST, Schwendener R, Detmar M, Schlapbach C, Stein JV. Intravital and whole-organ imaging reveals capture of melanoma-derived antigen by lymph node subcapsular macrophages leading to widespread deposition on follicular dendritic cells. Front Immunol. 2015 Mar 13;6:114.

    Moalli F, Cupovic J, Thelen F, Halbherr P, Fukui Y, Narumiya S, Ludewig B, Stein JV. Thromboxane A2 acts as tonic immunoregulator by preferential disruption of low-avidity CD4+ T cell-dendritic cell interactions. J Exp Med. 2014 Dec 15;211(13):2507-17.

    Coelho FM, Natale D, Soriano SF, Hons M, Swoger J, Mayer J, Danuser R, Scandella E, Pieczyk M, Zerwes HG, Junt T, Sailer AW, Ludewig B, Sharpe J, Figge MT, Stein JV. Naive B-cell trafficking is shaped by local chemokine availability and LFA-1-independent stromal interactions. Blood. 2013 May 16;121(20):4101-9.


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